O52733 (XYLT_LACBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-xylose-proton symporter

Alternative name(s):
D-xylose transporter

Gene names

Name:

xylT

Organism

Lactobacillus brevis

Taxonomic identifier

1580 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	457 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Ontologies

Keywords
Biological process	Sugar transport Symport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Gene Ontology (GO)
Biological process	carbohydrate transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	substrate-specific transmembrane transporter activity Inferred from electronic annotation. Source: InterPro symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 457	457	D-xylose-proton symporter		PRO_0000050296
Regions
	Topological domain	1 – 13	13	Cytoplasmic Potential
	Transmembrane	14 – 34	21	Helical; Name=1; Potential
	Topological domain	35 – 45	11	Extracellular Potential
	Transmembrane	46 – 66	21	Helical; Name=2; Potential
	Topological domain	67 – 80	14	Cytoplasmic Potential
	Transmembrane	81 – 101	21	Helical; Name=3; Potential
	Topological domain	102 – 103	2	Extracellular Potential
	Transmembrane	104 – 124	21	Helical; Name=4; Potential
	Topological domain	125 – 130	6	Cytoplasmic Potential
	Transmembrane	131 – 151	21	Helical; Name=5; Potential
	Topological domain	152 – 163	12	Extracellular Potential
	Transmembrane	164 – 184	21	Helical; Name=6; Potential
	Topological domain	185 – 243	59	Cytoplasmic Potential
	Transmembrane	244 – 264	21	Helical; Name=7; Potential
	Topological domain	265 – 280	16	Extracellular Potential
	Transmembrane	281 – 301	21	Helical; Name=8; Potential
	Topological domain	302 – 309	8	Cytoplasmic Potential
	Transmembrane	310 – 330	21	Helical; Name=9; Potential
	Topological domain	331 – 337	7	Extracellular Potential
	Transmembrane	338 – 358	21	Helical; Name=10; Potential
	Topological domain	359 – 379	21	Cytoplasmic Potential
	Transmembrane	380 – 400	21	Helical; Name=11; Potential
	Topological domain	401	1	Extracellular Potential
	Transmembrane	402 – 422	21	Helical; Name=12; Potential
	Topological domain	423 – 457	35	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	O52733 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: E097EB2B67A92F67	FASTA	457	49,199
	10 20 30 40 50 60 MRKVSTGFVY FFGALGGLLF GYDTGVISGA ILFIQKQMNL GSWQQGWVVS AVLLGAILGA 70 80 90 100 110 120 AIIGPSSDRF GRRKLLLLSA IIFFVGALGS AFSPEFWTLI ISRIILGMAV GAASALIPTY 130 140 150 160 170 180 LAELAPSDKR GTVSSLFQLM VMTGILLAYI TNYSFSGFYT GWRWMLGFAA IPAALLFLGG 190 200 210 220 230 240 LILPESPRFL VKSGHLDEAR HVLDTMNKHD QVAVNKEIND IQESAKIVSG GWSELFGKMV 250 260 270 280 290 300 RPSLIIGIGL AIFQQVMGCN TVLYYAPTIF TDVGFGVSAA LLAHIGIGIF NVIVTAIAVA 310 320 330 340 350 360 IMDKIDRKKI VNIGAVGMGI SLFVMSIGMK FSGGSQTAAI ISVIALTVYI AFFSATWGPV 370 380 390 400 410 420 MWVMIGEVFP LNIRGLGNSF ASVINWTANM IVSLTFPSLL DFFGTGSLFI GYGILCFASI 430 440 450 WFVQKKVFET RNRSLEDIEA TLRAKTGEDA AELSTTK

References

[1]	Chaillou S., Bor Y.-C., Batt C.A., Postma P., Pouwels P. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF045552 Genomic DNA. Translation: AAC95127.1.
3D structure databases
ProteinModelPortal	O52733.
ModBase	Search...
Protein family/group databases
TCDB	2.A.1.1.41. major facilitator superfamily (MFS).
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
PRINTS	PR00171. SUGRTRNSPORT.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLT_LACBR

Accession

Primary (citable) accession number: O52733

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	May 31, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program