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Protein

D-xylose-proton symporter

Gene

xylT

Organism
Lactobacillus brevis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138MonosaccharideBy similarity1
Binding sitei362MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Symport, Transport

Protein family/group databases

TCDBi2.A.1.1.41. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
D-xylose-proton symporter
Alternative name(s):
D-xylose transporter
Gene namesi
Name:xylT
OrganismiLactobacillus brevis
Taxonomic identifieri1580 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini35 – 45ExtracellularSequence analysisAdd BLAST11
Transmembranei46 – 66Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini67 – 80CytoplasmicSequence analysisAdd BLAST14
Transmembranei81 – 101Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini102 – 103ExtracellularSequence analysis2
Transmembranei104 – 124Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini125 – 130CytoplasmicSequence analysis6
Transmembranei131 – 151Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini152 – 163ExtracellularSequence analysisAdd BLAST12
Transmembranei164 – 184Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini185 – 243CytoplasmicSequence analysisAdd BLAST59
Transmembranei244 – 264Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini265 – 280ExtracellularSequence analysisAdd BLAST16
Transmembranei281 – 301Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini302 – 309CytoplasmicSequence analysis8
Transmembranei310 – 330Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini331 – 337ExtracellularSequence analysis7
Transmembranei338 – 358Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini359 – 379CytoplasmicSequence analysisAdd BLAST21
Transmembranei380 – 400Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini401ExtracellularSequence analysis1
Transmembranei402 – 422Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini423 – 457CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000502961 – 457D-xylose-proton symporterAdd BLAST457

Interactioni

Protein-protein interaction databases

STRINGi387344.LVIS_0186.

Structurei

3D structure databases

ProteinModelPortaliO52733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni254 – 260Monosaccharide bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QNK. Bacteria.
ENOG410XNQK. LUCA.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O52733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKVSTGFVY FFGALGGLLF GYDTGVISGA ILFIQKQMNL GSWQQGWVVS
60 70 80 90 100
AVLLGAILGA AIIGPSSDRF GRRKLLLLSA IIFFVGALGS AFSPEFWTLI
110 120 130 140 150
ISRIILGMAV GAASALIPTY LAELAPSDKR GTVSSLFQLM VMTGILLAYI
160 170 180 190 200
TNYSFSGFYT GWRWMLGFAA IPAALLFLGG LILPESPRFL VKSGHLDEAR
210 220 230 240 250
HVLDTMNKHD QVAVNKEIND IQESAKIVSG GWSELFGKMV RPSLIIGIGL
260 270 280 290 300
AIFQQVMGCN TVLYYAPTIF TDVGFGVSAA LLAHIGIGIF NVIVTAIAVA
310 320 330 340 350
IMDKIDRKKI VNIGAVGMGI SLFVMSIGMK FSGGSQTAAI ISVIALTVYI
360 370 380 390 400
AFFSATWGPV MWVMIGEVFP LNIRGLGNSF ASVINWTANM IVSLTFPSLL
410 420 430 440 450
DFFGTGSLFI GYGILCFASI WFVQKKVFET RNRSLEDIEA TLRAKTGEDA

AELSTTK
Length:457
Mass (Da):49,199
Last modified:June 1, 1998 - v1
Checksum:iE097EB2B67A92F67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045552 Genomic DNA. Translation: AAC95127.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045552 Genomic DNA. Translation: AAC95127.1.

3D structure databases

ProteinModelPortaliO52733.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi387344.LVIS_0186.

Protein family/group databases

TCDBi2.A.1.1.41. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4107QNK. Bacteria.
ENOG410XNQK. LUCA.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYLT_LACBR
AccessioniPrimary (citable) accession number: O52733
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.