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Protein

D-xylose transporter

Gene

xylT

Organism
Lactobacillus brevis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Transport is driven by the proton motive force generated by either malolactic fermentation or by the metabolism of D-glucose.1 Publication

Enzyme regulationi

Transport is inhibited by 6-deoxy-D-glucose.1 Publication

Kineticsi

  1. KM=215 µM for D-xylose1 Publication
  1. Vmax=35 nmol/min/mg enzyme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138MonosaccharideBy similarity1
Binding sitei362MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Symport, Transport

Protein family/group databases

TCDBi2.A.1.1.41. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
D-xylose transporter1 Publication
Alternative name(s):
D-xylose-proton symporter1 Publication
Gene namesi
Name:xylT1 Publication
OrganismiLactobacillus brevis
Taxonomic identifieri1580 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000502961 – 457D-xylose transporterAdd BLAST457

Expressioni

Inductioni

By D-xylose.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO52733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni254 – 260Monosaccharide bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QNK. Bacteria.
ENOG410XNQK. LUCA.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
PfamiView protein in Pfam
PF00083. Sugar_tr. 1 hit.
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O52733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKVSTGFVY FFGALGGLLF GYDTGVISGA ILFIQKQMNL GSWQQGWVVS
60 70 80 90 100
AVLLGAILGA AIIGPSSDRF GRRKLLLLSA IIFFVGALGS AFSPEFWTLI
110 120 130 140 150
ISRIILGMAV GAASALIPTY LAELAPSDKR GTVSSLFQLM VMTGILLAYI
160 170 180 190 200
TNYSFSGFYT GWRWMLGFAA IPAALLFLGG LILPESPRFL VKSGHLDEAR
210 220 230 240 250
HVLDTMNKHD QVAVNKEIND IQESAKIVSG GWSELFGKMV RPSLIIGIGL
260 270 280 290 300
AIFQQVMGCN TVLYYAPTIF TDVGFGVSAA LLAHIGIGIF NVIVTAIAVA
310 320 330 340 350
IMDKIDRKKI VNIGAVGMGI SLFVMSIGMK FSGGSQTAAI ISVIALTVYI
360 370 380 390 400
AFFSATWGPV MWVMIGEVFP LNIRGLGNSF ASVINWTANM IVSLTFPSLL
410 420 430 440 450
DFFGTGSLFI GYGILCFASI WFVQKKVFET RNRSLEDIEA TLRAKTGEDA

AELSTTK
Length:457
Mass (Da):49,199
Last modified:June 1, 1998 - v1
Checksum:iE097EB2B67A92F67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045552 Genomic DNA. Translation: AAC95127.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiXYLT_LACBR
AccessioniPrimary (citable) accession number: O52733
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: July 5, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families