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Protein

D-arabinitol 4-dehydrogenase

Gene

dalD

Organism
Klebsiella pneumoniae
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-arabinitol + NAD+ = D-xylulose + NADH.

Pathwayi: D-arabinitol metabolism

This protein is involved in the pathway D-arabinitol metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway D-arabinitol metabolism and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00380.

Names & Taxonomyi

Protein namesi
Recommended name:
D-arabinitol 4-dehydrogenase (EC:1.1.1.11)
Gene namesi
Name:dalD
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455D-arabinitol 4-dehydrogenasePRO_0000170735Add
BLAST

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi272620.KPN_02543.

Structurei

3D structure databases

ProteinModelPortaliO52720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannitol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105DEI. Bacteria.
COG0246. LUCA.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

O52720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNQFTWLHI GLGSFHRAHQ AWYLHRLIAS GDNRWRIAAG NIRNDAEQVV
60 70 80 90 100
QALAAQGGRY VLETVSPEGE REYEEITSIQ KLLPWQAGLQ PLINEGANPQ
110 120 130 140 150
TKVIAFTVTE GGYYLNTRHR LETSNPDLQA DLQGECKTIY GTLARILEKR
160 170 180 190 200
MADNAGPLTL LNCDNVRHNG ERFHDGMVEF LQLTGKQAVI DWMAANTTCP
210 220 230 240 250
NTMVDRITPR PAADLPARIK AQAGIDDKAP VMGETFIQWV VENNFRDVRP
260 270 280 290 300
NLEAVGVEMV ESVIPYEEAK IRILNASHSC IAWAGTLIGQ QYIHESTLTD
310 320 330 340 350
VIYAIADRYV TEDVIPCLGD NGIDLPTYRD VVLKRFTNPY IQDTNQRVAA
360 370 380 390 400
DGFSKIPAMI APTLQECYQR GVRPEATAML PALFFVFMEQ WHKGTLPYQY
410 420 430 440 450
QDGILDAQAV HEMFEAQDPV AVFARDKALF GDLANNADFL ALMREKVAAV

YTLIN
Length:455
Mass (Da):51,022
Last modified:June 1, 1998 - v1
Checksum:i2D446E5232778DD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045245 Genomic DNA. Translation: AAC26498.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045245 Genomic DNA. Translation: AAC26498.1.

3D structure databases

ProteinModelPortaliO52720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_02543.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105DEI. Bacteria.
COG0246. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00380.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genes for D-arabinitol and ribitol catabolism from Klebsiella pneumoniae."
    Heuel H., Shakeri-Garakani A., Turgut S., Lengeler J.W.
    Microbiology 144:1631-1639(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 1033-5P14 / KAY2026.

Entry informationi

Entry nameiDALD_KLEPN
AccessioniPrimary (citable) accession number: O52720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 1, 1998
Last modified: December 9, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.