O52720 (DALD_KLEPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-arabinitol 4-dehydrogenase
EC=1.1.1.11

Gene names

Name:

dalD

Organism

Klebsiella pneumoniae

Taxonomic identifier

573 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-arabinitol + NAD+ = D-xylulose + NADH.
Pathway	Carbohydrate metabolism; D-arabinitol metabolism.
Subunit structure	Monomer.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Molecular function	D-arabinitol 4-dehydrogenase activity Inferred from electronic annotation. Source: EC coenzyme binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	D-arabinitol 4-dehydrogenase		PRO_0000170735

Sequences

	Sequence		Length	Mass (Da)
	O52720 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 2D446E5232778DD5	FASTA	455	51,022
	10 20 30 40 50 60 MNNQFTWLHI GLGSFHRAHQ AWYLHRLIAS GDNRWRIAAG NIRNDAEQVV QALAAQGGRY 70 80 90 100 110 120 VLETVSPEGE REYEEITSIQ KLLPWQAGLQ PLINEGANPQ TKVIAFTVTE GGYYLNTRHR 130 140 150 160 170 180 LETSNPDLQA DLQGECKTIY GTLARILEKR MADNAGPLTL LNCDNVRHNG ERFHDGMVEF 190 200 210 220 230 240 LQLTGKQAVI DWMAANTTCP NTMVDRITPR PAADLPARIK AQAGIDDKAP VMGETFIQWV 250 260 270 280 290 300 VENNFRDVRP NLEAVGVEMV ESVIPYEEAK IRILNASHSC IAWAGTLIGQ QYIHESTLTD 310 320 330 340 350 360 VIYAIADRYV TEDVIPCLGD NGIDLPTYRD VVLKRFTNPY IQDTNQRVAA DGFSKIPAMI 370 380 390 400 410 420 APTLQECYQR GVRPEATAML PALFFVFMEQ WHKGTLPYQY QDGILDAQAV HEMFEAQDPV 430 440 450 AVFARDKALF GDLANNADFL ALMREKVAAV YTLIN

References

[1]	"Genes for D-arabinitol and ribitol catabolism from Klebsiella pneumoniae." Heuel H., Shakeri-Garakani A., Turgut S., Lengeler J.W. Microbiology 144:1631-1639(1998) [PubMed: 9639934] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 1033-5P14 / KAY2026.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF045245 Genomic DNA. Translation: AAC26498.1.
3D structure databases
ProteinModelPortal	O52720.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DALD_KLEPN

Accession

Primary (citable) accession number: O52720

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	June 1, 1998
Last modified:	December 14, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program