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Protein

50S ribosomal protein L1

Gene

rpl1

Organism
Methanothermococcus thermolithotrophicus (Methanococcus thermolithotrophicus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.By similarity
Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor, Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

RNA-binding, rRNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L1UniRule annotation
Alternative name(s):
ML6
MvaL1
Gene namesi
Name:rpl1UniRule annotation
OrganismiMethanothermococcus thermolithotrophicus (Methanococcus thermolithotrophicus)
Taxonomic identifieri2186 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanothermococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21321350S ribosomal protein L1PRO_0000125802Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.

Structurei

Secondary structure

1
213
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1513Combined sources
Beta strandi25 – 328Combined sources
Helixi40 – 423Combined sources
Beta strandi45 – 495Combined sources
Beta strandi60 – 634Combined sources
Helixi67 – 748Combined sources
Beta strandi78 – 803Combined sources
Helixi82 – 909Combined sources
Helixi92 – 10110Combined sources
Beta strandi103 – 1086Combined sources
Helixi109 – 1113Combined sources
Helixi112 – 1176Combined sources
Helixi120 – 1267Combined sources
Beta strandi131 – 1333Combined sources
Helixi139 – 1479Combined sources
Beta strandi149 – 1535Combined sources
Beta strandi157 – 16610Combined sources
Helixi171 – 18818Combined sources
Beta strandi189 – 1913Combined sources
Helixi192 – 1954Combined sources
Beta strandi196 – 2027Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DWUX-ray2.80A/B1-213[»]
ProteinModelPortaliO52704.
SMRiO52704. Positions 1-213.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO52704.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L1P family.UniRule annotation

Family and domain databases

Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
HAMAPiMF_01318_A. Ribosomal_L1_A.
InterProiIPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023669. Ribosomal_L1_arc.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O52704-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRENILKAV KEARSLAKPR NFTQSLDLII NLKELDLSRP ENRLKEQVVL
60 70 80 90 100
PNGRGKEPKI AVIAKGDLAA QAEEMGLTVI RQDELEELGK NKKMAKKIAN
110 120 130 140 150
EHDFFIAQAD MMPLVGKTLG PVLGPRGKMP QPVPANANLT PLVERLKKTV
160 170 180 190 200
LINTRDKPLF HVLVGNEKMS DEELAENIEA ILNTVSRKYE KGLYHVKSAY
210
TKLTMGPPAQ IEK
Length:213
Mass (Da):23,794
Last modified:June 1, 1998 - v1
Checksum:iC435C5064300E5A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044919 Genomic DNA. Translation: AAC64510.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044919 Genomic DNA. Translation: AAC64510.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DWUX-ray2.80A/B1-213[»]
ProteinModelPortaliO52704.
SMRiO52704. Positions 1-213.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO52704.

Family and domain databases

Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
HAMAPiMF_01318_A. Ribosomal_L1_A.
InterProiIPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023669. Ribosomal_L1_arc.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Linhart A., Piendl W.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Interaction of ribosomal L1 proteins from mesophilic and thermophilic Archaea and Bacteria with specific L1-binding sites on 23S rRNA and mRNA."
    Koehrer C., Mayer C., Neumair O., Groebner P., Piendl W.
    Eur. J. Biochem. 256:97-105(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: BINDING TO ENDOGENOUS 23S RRNA, TO METHANOCOCCUS VANNIELII L1 MRNA.
  3. "Structure of ribosomal protein L1 from Methanococcus thermolithotrophicus. Functionally important structural invariants on the L1 surface."
    Nevskaya N., Tishchenko S., Paveliev M., Smolinskaya Y., Fedorov R., Piendl W., Nakamura Y., Toyoda T., Garber M.B., Nikonov S.
    Acta Crystallogr. D 58:1023-1029(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).

Entry informationi

Entry nameiRL1_METTL
AccessioniPrimary (citable) accession number: O52704
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: October 14, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.