O52683 (O52683_THEMT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Fe-hydrogenase alpha subunit EMBL AAC02686.1

Gene names

Name:

hydA EMBL AAC02686.1

Organism

Thermotoga maritima EMBL AAC02686.1

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Thermotogae › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	645 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	4Fe-4S RuleBase RU003429 Iron Iron-sulfur Metal-binding
Gene Ontology (GO)
Biological_process	ATP synthesis coupled electron transport Inferred from electronic annotation. Source: InterPro
Cellular_component	membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O52683 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 817111261966B58F	FASTA	645	72,254
	10 20 30 40 50 60 MKIYVDGREV IINDNERNLL EALKNVGIEI PNLCYLSEAS IYGACRMCLV EINGQITTSC 70 80 90 100 110 120 TLKPYEGMKV KTNTPEIYEM RRNILELILA THNRDCTTCD RNGSCKLQKY AEDFGIRKIR 130 140 150 160 170 180 FEALKKEHVR DESAPVVRDT SKCILCGDCV RVCEEIQGVG VIEFAKRGFE SVVTTAFDTP 190 200 210 220 230 240 LIETECVLCG QCVAYCPTGA LSIRNDIDKL IEALESDKIV IGMIAPAVRA AIQEEFGIDE 250 260 270 280 290 300 DVAMAEKLVS FLKTIGFDKV FDVSFGADLV AYEEAHEFYE RLKKGERLPQ FTSCCPAWVK 310 320 330 340 350 360 HAEHTYPQYL QNLSSVKSPQ QALGTVIKKI YARKLGVPEE KIFLVSFMPC TAKKFEAERE 370 380 390 400 410 420 EHEGIVDIVL TTRELAQLIK MSRIDINRVE PQPFDRPYGV SSQAGLGFGK AGGVFSCVLS 430 440 450 460 470 480 VLNEEIGIEK VDVKSPEDGI RVAEVTLKDG TSFKGAVIYG LGKVKKFLEE RKDVEIIEVM 490 500 510 520 530 540 ACNYGCVGGG GQPYPNDSRI REHRAKVLRD TMGIKSLLTP VENLFLMKLY EEDLKDEHTR 550 560 570 580 590 600 HEILHTTYRP RRRYPEKDVE ILPVPNGEKR TVKVCLGTSC YTKGSYEILK KLVDYVKEND 610 620 630 640 MEGKIEVLGT FCVENCGASP NVIVDDKIIG GATFEKVLEE LSKNG

References

[1]	O'Rourke T.W., Verhagen M.F.J.M., Adams M.W.W. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: DSM 3109 EMBL AAC02686.1.
[2]	"The hyperthermophilic bacterium, Thermotoga maritima, contains an unusually complex iron-hydrogenase: amino acid sequence analyses versus biochemical characterization." Verhagen M.F., O'Rourke T., Adams M.W. Biochim. Biophys. Acta 1412:212-229(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: DSM 3109 EMBL AAC02686.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF044577 Genomic DNA. Translation: AAC02686.1.
PIR	G72256.
RefSeq	NP_229226.1. NC_000853.1.
3D structure databases
HSSP	HSSP built from PDB template 1HFE based on UniProtKB P07598.
ProteinModelPortal	O52683.
ModBase	Search...
Protein-protein interaction databases
STRING	243274.TM1426.
Protocols and materials databases
DNASU	898049.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	898049.
KEGG	tma:TM1426.
PATRIC	23937800. VBITheMar51294_1438.
Phylogenomic databases
KO	K00336.
ProtClustDB	CLSK875754.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-261.
Family and domain databases
Gene3D	3.40.30.10. 1 hit. 4.10.260.20. 1 hit.
InterPro	IPR002023. 2Fe-2S_Ferredox. IPR001041. 2Fe-2S_ferredoxin-type. IPR001450. 4Fe4S-bd_dom. IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. IPR009016. Fe_hydrogenase. IPR004108. Fe_hydrogenase_lsu_C. IPR003149. Fe_hydrogenase_ssu-like. IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS. IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF01257. Complex1_24kDa. 1 hit. PF02906. Fe_hyd_lg_C. 1 hit. PF02256. Fe_hyd_SSU. 1 hit. PF00111. Fer2. 1 hit. PF00037. Fer4. 1 hit. PF12837. Fer4_6. 1 hit. PF10588. NADH-G_4Fe-4S_3. 1 hit. [Graphical view]
SMART	SM00902. Fe_hyd_SSU. 1 hit. SM00929. NADH-G_4Fe-4S_3. 1 hit. [Graphical view]
SUPFAM	SSF53920. Fe_hydrog. 1 hit. SSF54292. Ferredoxin. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS51085. 2FE2S_FER_2. 1 hit. PS00198. 4FE4S_FER_1. 2 hits. PS51379. 4FE4S_FER_2. 2 hits. PS00641. COMPLEX1_75K_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O52683_THEMT

Accession

Primary (citable) accession number: O52683

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)