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O52632

- PGK_CLOAB

UniProt

O52632 - PGK_CLOAB

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381SubstrateBy similarity
    Binding sitei121 – 1211SubstrateBy similarity
    Binding sitei154 – 1541SubstrateBy similarity
    Binding sitei205 – 2051ATPBy similarity
    Binding sitei296 – 2961ATP; via carbonyl oxygenBy similarity
    Binding sitei327 – 3271ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi353 – 3564ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCACE272562:GJIH-753-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:pgk
    Ordered Locus Names:CA_C0710
    OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
    Taxonomic identifieri272562 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000814: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397Phosphoglycerate kinasePRO_0000145931Add
    BLAST

    PTM databases

    PhosSiteiP12081777.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi272562.CA_C0710.

    Structurei

    3D structure databases

    ProteinModelPortaliO52632.
    SMRiO52632. Positions 5-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 253Substrate bindingBy similarity
    Regioni61 – 644Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227108.
    KOiK00927.
    OMAiWEALDIG.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O52632-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFNKKTIED VDVKGKRVLV RCDFNVPLKD GVITDENRLN GALPTIKYLS    50
    EHGGKVILCS HLGKAKGPDP SKTLAPVAKR LSELLGREVK FAADDTVVGE 100
    NAKKAVAELK EGEIVLLENT RFRPEEGKND DAFSKDLASL ADVYVNDAFG 150
    TAHRAHCSTV GVTKFVDTAV CGYLIQKELK FLGSAVENPV RPFVAILGGA 200
    KVSDKINVIN NLLEKVDTLI IGGGMAYTFL KAQGYTIGTS LLEADKVDYA 250
    KEMIEKAEAK GVKLLLPIDN IVGAEFKADT KAVTTEDANI PEGYMGLDIG 300
    PKTQKLYADA VKEAKTVVWN GPMGVFEFEN FAKGTKDVAK AMAESDATTV 350
    IGGGDSAAAV NQLGFGDKMT HISTGGGASL EFLEGKELPG IVALNDK 397
    Length:397
    Mass (Da):42,384
    Last modified:June 1, 1998 - v1
    Checksum:i8F1C993B0447966B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043386 Genomic DNA. Translation: AAC13161.1.
    AE001437 Genomic DNA. Translation: AAK78687.1.
    PIRiD96987.
    RefSeqiNP_347347.1. NC_003030.1.

    Genome annotation databases

    EnsemblBacteriaiAAK78687; AAK78687; CA_C0710.
    GeneIDi1116893.
    KEGGicac:CA_C0710.
    PATRICi32035787. VBICloAce74127_0913.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043386 Genomic DNA. Translation: AAC13161.1 .
    AE001437 Genomic DNA. Translation: AAK78687.1 .
    PIRi D96987.
    RefSeqi NP_347347.1. NC_003030.1.

    3D structure databases

    ProteinModelPortali O52632.
    SMRi O52632. Positions 5-397.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272562.CA_C0710.

    PTM databases

    PhosSitei P12081777.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK78687 ; AAK78687 ; CA_C0710 .
    GeneIDi 1116893.
    KEGGi cac:CA_C0710.
    PATRICi 32035787. VBICloAce74127_0913.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227108.
    KOi K00927.
    OMAi WEALDIG.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci CACE272562:GJIH-753-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The glyceraldehyde-3-phosphate dehydrogenase of Clostridium acetobutylicum: isolation and purification of the enzyme, and sequencing and localization of the gap gene within a cluster of other glycolytic genes."
      Schreiber W., Durre P.
      Microbiology 145:1839-1847(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

    Entry informationi

    Entry nameiPGK_CLOAB
    AccessioniPrimary (citable) accession number: O52632
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3