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O52632

- PGK_CLOAB

UniProt

O52632 - PGK_CLOAB

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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381SubstrateBy similarity
Binding sitei121 – 1211SubstrateBy similarity
Binding sitei154 – 1541SubstrateBy similarity
Binding sitei205 – 2051ATPBy similarity
Binding sitei296 – 2961ATP; via carbonyl oxygenBy similarity
Binding sitei327 – 3271ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi353 – 3564ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCACE272562:GJIH-753-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:CA_C0710
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000814: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Phosphoglycerate kinasePRO_0000145931Add
BLAST

PTM databases

PhosSiteiP12081777.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi272562.CA_C0710.

Structurei

3D structure databases

ProteinModelPortaliO52632.
SMRiO52632. Positions 5-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 253Substrate bindingBy similarity
Regioni61 – 644Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227108.
KOiK00927.
OMAiWEALDIG.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O52632-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFNKKTIED VDVKGKRVLV RCDFNVPLKD GVITDENRLN GALPTIKYLS
60 70 80 90 100
EHGGKVILCS HLGKAKGPDP SKTLAPVAKR LSELLGREVK FAADDTVVGE
110 120 130 140 150
NAKKAVAELK EGEIVLLENT RFRPEEGKND DAFSKDLASL ADVYVNDAFG
160 170 180 190 200
TAHRAHCSTV GVTKFVDTAV CGYLIQKELK FLGSAVENPV RPFVAILGGA
210 220 230 240 250
KVSDKINVIN NLLEKVDTLI IGGGMAYTFL KAQGYTIGTS LLEADKVDYA
260 270 280 290 300
KEMIEKAEAK GVKLLLPIDN IVGAEFKADT KAVTTEDANI PEGYMGLDIG
310 320 330 340 350
PKTQKLYADA VKEAKTVVWN GPMGVFEFEN FAKGTKDVAK AMAESDATTV
360 370 380 390
IGGGDSAAAV NQLGFGDKMT HISTGGGASL EFLEGKELPG IVALNDK
Length:397
Mass (Da):42,384
Last modified:June 1, 1998 - v1
Checksum:i8F1C993B0447966B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043386 Genomic DNA. Translation: AAC13161.1.
AE001437 Genomic DNA. Translation: AAK78687.1.
PIRiD96987.
RefSeqiNP_347347.1. NC_003030.1.

Genome annotation databases

EnsemblBacteriaiAAK78687; AAK78687; CA_C0710.
GeneIDi1116893.
KEGGicac:CA_C0710.
PATRICi32035787. VBICloAce74127_0913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043386 Genomic DNA. Translation: AAC13161.1 .
AE001437 Genomic DNA. Translation: AAK78687.1 .
PIRi D96987.
RefSeqi NP_347347.1. NC_003030.1.

3D structure databases

ProteinModelPortali O52632.
SMRi O52632. Positions 5-397.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272562.CA_C0710.

PTM databases

PhosSitei P12081777.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK78687 ; AAK78687 ; CA_C0710 .
GeneIDi 1116893.
KEGGi cac:CA_C0710.
PATRICi 32035787. VBICloAce74127_0913.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227108.
KOi K00927.
OMAi WEALDIG.
OrthoDBi EOG64N9Z0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci CACE272562:GJIH-753-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The glyceraldehyde-3-phosphate dehydrogenase of Clostridium acetobutylicum: isolation and purification of the enzyme, and sequencing and localization of the gap gene within a cluster of other glycolytic genes."
    Schreiber W., Durre P.
    Microbiology 145:1839-1847(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Entry informationi

Entry nameiPGK_CLOAB
AccessioniPrimary (citable) accession number: O52632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3