ID   ACKA_CLOTH              Reviewed;         399 AA.
AC   O52594; A3DE81;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   16-JUN-2009, entry version 51.
DE   RecName: Full=Acetate kinase;
DE            EC=2.7.2.1;
DE   AltName: Full=Acetokinase;
GN   Name=ackA; Synonyms=ack; OrderedLocusNames=Cthe_1028;
OS   Clostridium thermocellum (strain ATCC 27405 / DSM 1237).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=203119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Stevens D.R., Guerinot M.L., Lynd L.R.;
RL   Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R.,
RA   Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Wu J.H.D., Newcomb M., Richardson P.;
RT   "Complete sequence of Clostridium thermocellum ATCC 27405.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the activation of acetate to acetyl CoA and
CC       the secretion of acetate (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + acetate = ADP + acetyl phosphate.
CC   -!- CATALYTIC ACTIVITY: ATP + propanoate = ADP + propanoyl phosphate.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; acetyl-CoA
CC       biosynthesis; acetyl-CoA from acetate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the acetokinase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF041841; AAB96952.1; -; Genomic_DNA.
DR   EMBL; CP000568; ABN52260.1; -; Genomic_DNA.
DR   RefSeq; YP_001037453.1; -.
DR   HSSP; P38502; 1G99.
DR   GeneID; 4811322; -.
DR   GenomeReviews; CP000568_GR; Cthe_1028.
DR   KEGG; cth:Cthe_1028; -.
DR   NMPDR; fig|203119.1.peg.567; -.
DR   OMA; O52594; SSDFRDV.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008776; F:acetate kinase activity; IEA:HAMAP.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006082; P:organic acid metabolic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:HAMAP.
DR   HAMAP; MF_00020; -; 1.
DR   InterPro; IPR000890; Acetate_kin.
DR   InterPro; IPR004372; AckA.
DR   PANTHER; PTHR21060; Acetate_kin; 1.
DR   PANTHER; PTHR21060:SF11; AckA; 1.
DR   Pfam; PF00871; Acetate_kinase; 1.
DR   PIRSF; PIRSF000722; Acetate_prop_kin; 1.
DR   PRINTS; PR00471; ACETATEKNASE.
DR   TIGRFAMs; TIGR00016; ackA; 1.
DR   PROSITE; PS01075; ACETATE_KINASE_1; 1.
DR   PROSITE; PS01076; ACETATE_KINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding;
KW   Transferase.
FT   CHAIN         1    399       Acetate kinase.
FT                                /FTId=PRO_0000107549.
SQ   SEQUENCE   399 AA;  43966 MW;  1DEF07FA0A72226B CRC64;
     MNILVINTGS SSLKYQLIDM TNESVLAKGV CDRIGLEHSF LKHTKTGGET VVIEKDLYNH
     KLAIQEVISA LTDEKIGVIK SMSEISAVGH RIVHGGEKFK ESAIIDEDVM KAIRDCVELA
     PLHNPSNIIG IEACKQILPD VPMVAVFDTA FHQTMPRHAY IYALPYEIYE KYKLRKYGFH
     GTSHKYVAHR AAQMLGKPIE SLKLITCHLG NGASICAVKG GKSVDTSMGF TPLQGLCMGT
     RSGNVDPAVI TYLMEKEKMN INDINNFLNK KSGVLGISGV SSDFRDVQDA AEKGDDRAQL
     ALDIFCYGVR KYIGKYIAVL NGVDAVVFTA GIGENNAYIR REVLKDMDFF GIKIDLDKNE
     VKGKEADISA PDAKVKTLVI PTNEELEIAR ETLRLVKNL
//