O52594 (ACKA_CLOTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase
EC=2.7.2.1

Alternative name(s):
Acetokinase

Gene names

Name:	ackA
Synonyms:	ack
Ordered Locus Names:	Cthe_1028

Organism

Clostridium thermocellum (strain ATCC 27405 / DSM 1237) [Complete proteome] [HAMAP]

Taxonomic identifier

203119 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the activation of acetate to acetyl CoA and the secretion of acetate By similarity. HAMAP MF_00020
Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Acetate kinase HAMAP MF_00020		PRO_0000107549

Sequences

	Sequence		Length	Mass (Da)
	O52594 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 1DEF07FA0A72226B	FASTA	399	43,966
	10 20 30 40 50 60 MNILVINTGS SSLKYQLIDM TNESVLAKGV CDRIGLEHSF LKHTKTGGET VVIEKDLYNH 70 80 90 100 110 120 KLAIQEVISA LTDEKIGVIK SMSEISAVGH RIVHGGEKFK ESAIIDEDVM KAIRDCVELA 130 140 150 160 170 180 PLHNPSNIIG IEACKQILPD VPMVAVFDTA FHQTMPRHAY IYALPYEIYE KYKLRKYGFH 190 200 210 220 230 240 GTSHKYVAHR AAQMLGKPIE SLKLITCHLG NGASICAVKG GKSVDTSMGF TPLQGLCMGT 250 260 270 280 290 300 RSGNVDPAVI TYLMEKEKMN INDINNFLNK KSGVLGISGV SSDFRDVQDA AEKGDDRAQL 310 320 330 340 350 360 ALDIFCYGVR KYIGKYIAVL NGVDAVVFTA GIGENNAYIR REVLKDMDFF GIKIDLDKNE 370 380 390 VKGKEADISA PDAKVKTLVI PTNEELEIAR ETLRLVKNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Stevens D.R., Guerinot M.L., Lynd L.R. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of Clostridium thermocellum ATCC 27405." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Wu J.H.D., Newcomb M., Richardson P. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27405 / DSM 1237.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF041841 Genomic DNA. Translation: AAB96952.1. CP000568 Genomic DNA. Translation: ABN52260.1.
RefSeq	YP_001037453.1. NC_009012.1.
3D structure databases
ProteinModelPortal	O52594.
SMR	O52594. Positions 1-397.
ModBase	Search...
Protein-protein interaction databases
STRING	O52594.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4811322.
GenomeReviews	Gene locus Cthe_1028 in contig CP000568_GR.
KEGG	cth:Cthe_1028.
NMPDR	fig|203119.1.peg.567.
PATRIC	19515789. VBICloThe47081_1080.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0282.
HOGENOM	HBG285863.
OMA	LIDMTNE.
ProtClustDB	CLSK2471789.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_CLOTH

Accession

Primary (citable) accession number: O52594
Secondary accession number(s): A3DE81

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program