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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciCTHE203119:G1G86-1072-MONOMER
UniPathwayiUPA00340; UER00459

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:Cthe_1029
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000002145 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001791261 – 332Phosphate acetyltransferaseAdd BLAST332

Interactioni

Protein-protein interaction databases

STRINGi203119.Cthe_1029

Structurei

3D structure databases

ProteinModelPortaliO52593
SMRiO52593
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108IJ2 Bacteria
COG0280 LUCA
HOGENOMiHOG000053796
KOiK00625
OMAiTMLVKMG
OrthoDBiPOG091H01MW

Family and domain databases

InterProiView protein in InterPro
IPR012147 P_Ac_Bu_trans
IPR004614 P_AcTrfase
IPR002505 PTA_PTB
PfamiView protein in Pfam
PF01515 PTA_PTB, 1 hit
PIRSFiPIRSF000428 P_Ac_trans, 1 hit
TIGRFAMsiTIGR00651 pta, 1 hit

Sequencei

Sequence statusi: Complete.

O52593-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLEQIIER AKSDVKTIVL PESTDLRVIK AASMIMKKGI AKVVLIGNEK
60 70 80 90 100
EIKSLAGDID LEGVMIEDSL NSEKLEDYAN TLYELRKSKG MTIEAARETI
110 120 130 140 150
KDPLYYGVMM VKKGEADGMV AGAVNSTANT LRPALQILKT APGTKLVSSF
160 170 180 190 200
FVMVVPNCEY GHNGTFVYAD CGLVENPDAD QLSEIAISAS KSFEMLVGAK
210 220 230 240 250
PQVAMLSYSS YGSAKSELTE KVIKATQLAK EKAPHLAIDG ELQVDAAIVP
260 270 280 290 300
EVAKSKAKGS SVAGKANVLI FPDLDAGNIA YKLTQRLAKA EAYGPITQGL
310 320 330
ARPVNDLSRG CSAEDIVGVA AITAVQAQYV KA
Length:332
Mass (Da):35,396
Last modified:June 1, 1998 - v1
Checksum:iED97F638D6C84583
GO

Sequence cautioni

The sequence ABN52261 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041841 Genomic DNA Translation: AAB96951.1
CP000568 Genomic DNA Translation: ABN52261.1 Different initiation.
RefSeqiWP_041734229.1, NC_009012.1

Genome annotation databases

EnsemblBacteriaiABN52261; ABN52261; Cthe_1029
GeneIDi35805900
KEGGicth:Cthe_1029

Similar proteinsi

Entry informationi

Entry nameiPTAS_CLOTH
AccessioniPrimary (citable) accession number: O52593
Secondary accession number(s): A3DE82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: April 25, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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