O52593 (PTAS_CLOTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphate acetyltransferase
EC=2.3.1.8

Alternative name(s):
Phosphotransacetylase

Gene names

Name:	pta
Ordered Locus Names:	Cthe_1029

Organism

Clostridium thermocellum (strain ATCC 27405 / DSM 1237) [Complete proteome] [HAMAP]

Taxonomic identifier

203119 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acetyl-CoA + phosphate = CoA + acetyl phosphate.
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the phosphate acetyltransferase and butyryltransferase family.
Sequence caution	The sequence ABN52261.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphate acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Phosphate acetyltransferase		PRO_0000179126

Sequences

	Sequence		Length	Mass (Da)
	O52593 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: ED97F638D6C84583	FASTA	332	35,396
	10 20 30 40 50 60 MSFLEQIIER AKSDVKTIVL PESTDLRVIK AASMIMKKGI AKVVLIGNEK EIKSLAGDID 70 80 90 100 110 120 LEGVMIEDSL NSEKLEDYAN TLYELRKSKG MTIEAARETI KDPLYYGVMM VKKGEADGMV 130 140 150 160 170 180 AGAVNSTANT LRPALQILKT APGTKLVSSF FVMVVPNCEY GHNGTFVYAD CGLVENPDAD 190 200 210 220 230 240 QLSEIAISAS KSFEMLVGAK PQVAMLSYSS YGSAKSELTE KVIKATQLAK EKAPHLAIDG 250 260 270 280 290 300 ELQVDAAIVP EVAKSKAKGS SVAGKANVLI FPDLDAGNIA YKLTQRLAKA EAYGPITQGL 310 320 330 ARPVNDLSRG CSAEDIVGVA AITAVQAQYV KA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Stevens D.R., Guerinot M.L., Lynd L.R. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of Clostridium thermocellum ATCC 27405." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Wu J.H.D., Newcomb M., Richardson P. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27405 / DSM 1237.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF041841 Genomic DNA. Translation: AAB96951.1. CP000568 Genomic DNA. Translation: ABN52261.1. Different initiation.
RefSeq	YP_001037454.1. NC_009012.1.
3D structure databases
ProteinModelPortal	O52593.
SMR	O52593. Positions 1-327.
ModBase	Search...
Protein-protein interaction databases
STRING	O52593.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4811323.
GenomeReviews	Gene locus Cthe_1029 in contig CP000568_GR.
KEGG	cth:Cthe_1029.
NMPDR	fig|203119.1.peg.566.
PATRIC	19515791. VBICloThe47081_1081.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0280.
HOGENOM	HBG576804.
OMA	LVFPDLQ.
ProtClustDB	CLSK852494.
Family and domain databases
InterPro	IPR012147. P_Ac_Bu_trans. IPR004614. P_AcTrfase. IPR002505. PTA_PTB. [Graphical view]
KO	K00625.
Pfam	PF01515. PTA_PTB. 1 hit. [Graphical view]
PIRSF	PIRSF000428. P_Ac_trans. 1 hit.
TIGRFAMs	TIGR00651. Pta. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PTAS_CLOTH

Accession

Primary (citable) accession number: O52593
Secondary accession number(s): A3DE82

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program