O52550 (O52550_AMYMD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
RifH EMBL AAC01718.1

Gene names

Name:

rifH EMBL AAC01718.1

Organism

Amycolatopsis mediterranei (Nocardia mediterranei) EMBL AAC01718.1

Taxonomic identifier

33910 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Amycolatopsis

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O52550 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 515614B87B2F187E	FASTA	441	47,253
	10 20 30 40 50 60 MKRQPDFAAH GRAVDRVLAG RLSAALARPA AQQPGWPDAE RAAEVIELLH DAEPIVAPEE 70 80 90 100 110 120 TARLRARLAS VARGEAFLLQ GGDCAETFAG NTEPHLRANL GVLARMGEVL AEAAGLPVVK 130 140 150 160 170 180 IARMAGQFAK PRSRTVDALG LPVYRGDIVN SPECTVAART PDPHRMLLAY AHAAGAMDLV 190 200 210 220 230 240 RKLCAEGLEE PLAAQVVLAG ARRASSPGGR PFPDFGRPPR PAEIYVSHEM LLLDYERAVL 250 260 270 280 290 300 RTDSSGPEPR LSSGLAHFLW IGERPASSTA PTSTFAELLS NPIGLKLGPS CTPEEVVEYV 310 320 330 340 350 360 RRLDPHRTPG RLTLVSRMGH AQVRELLPPI VEKVAASGHE VIWQCDPMHG NTRTSGNGYK 370 380 390 400 410 420 TRHFGHVVAE LAGFFAVHRQ LGTHPGGIHV EVTGDDVTEC LGGAAGIAEA DLPDRYLTAC 430 440 DPRLNADQSV ELAFAIAKML R

References

[1]	"Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699." August P.R., Tang L., Yoon Y.J., Ning S., Muller R., Yu T.W., Taylor M., Hoffmann D., Kim C.G., Zhang X., Hutchinson C.R., Floss H.G. Chem. Biol. 5:69-79(1998) [PubMed: 9512878] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: S699 EMBL AAC01718.1.
[2]	"3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics." Kim C.G., Yu T.W., Fryhle C.B., Handa S., Floss H.G. J. Biol. Chem. 273:6030-6040(1998) [PubMed: 9497318] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: S699 EMBL AAC01718.1.
[3]	"Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699." Yu T.W., Muller R., Muller M., Zhang X., Draeger G., Kim C.G., Leistner E., Floss H.G. J. Biol. Chem. 276:12546-12555(2001) [PubMed: 11278540] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: S699 EMBL AAC01718.1.
[4]	"Rifamycin insusceptibility: exploring the rif gene cluster of Amycolatopsis mediterranei S699." Yu T.-W., Pogosova-Agadjanyan E.L., Kuan L.-Y., Bai L., Tin A.M., Adman E., Floss H.G. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: S699 EMBL AAC01718.1.
[5]	Yu T., August P.R., Tang L., Yoon Y.J., Ning S., Mueller R., Taylor M., Kim C., Zhang X., Pogosova-Agadjanyan E.L., Tin A.M., Hutchinson C.R., Floss H.G. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: S699 EMBL AAC01718.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF040570 Genomic DNA. Translation: AAC01718.1.
3D structure databases
ProteinModelPortal	O52550.
SMR	O52550. Positions 18-441.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002480. DAHP_synth_2. [Graphical view]
PANTHER	PTHR21337. DAHP_synth_2. 1 hit.
Pfam	PF01474. DAHP_synth_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O52550_AMYMD

Accession

Primary (citable) accession number: O52550

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	July 27, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)