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Protein
Submitted name:

Membrane NADH dehydrogenase NdhA

Gene

ndh

Organism
Mycobacterium smegmatis
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Membrane NADH dehydrogenase NdhAImported (EC:1.6.99.-Imported, EC:1.6.99.3Imported)
Submitted name:
NADH dehydrogenaseImported
Gene namesi
Name:ndhImported
Synonyms:ndh_1Imported
ORF Names:ERS451418_03587Imported
OrganismiMycobacterium smegmatisImported
Taxonomic identifieri1772 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000062612 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei384 – 40421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_3621.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 337326FAD/NAD-binding_domInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105CEP. Bacteria.
COG1252. LUCA.
KOiK03885.
OrthoDBiEOG6QZMR6.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.

Sequencei

Sequence statusi: Complete.

O52473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHPGATASD RHKVVIIGSG FGGLTAAKTL KRADVDVKLI ARTTHHLFQP
60 70 80 90 100
LLYQVATGII SEGEIAPATR VILRKQKNAQ VLLGDVTHID LENKTVDSVL
110 120 130 140 150
LGHTYSTPYD SLIIAAGAGQ SYFGNDHFAE FAPGMKSIDD ALELRGRILG
160 170 180 190 200
AFEQAERSSD PVRRAKLLTF TVVGAGPTGV EMAGQIAELA DQTLRGSFRH
210 220 230 240 250
IDPTEARVIL LDAAPAVLPP MGEKLGKKAR ARLEKMGVEV QLGAMVTDVD
260 270 280 290 300
RNGITVKDSD GTIRRIESAC KVWSAGVSAS PLGKDLAEQS GVELDRAGRV
310 320 330 340 350
KVQPDLTLPG HPNVFVVGDM AAVEGVPGVA QGAIQGGRYA AKIIKREVSG
360 370 380 390 400
TSPKIRTPFE YFDKGSMATV SRFSAVAKVG PVEFAGFFAW LCWLVLHLVY
410 420 430 440 450
LVGFKTKIVT LLSWGVTFLS TKRGQLTITE QQAYARTRIE ELEEIAAAVQ

DTEKAAS
Length:457
Mass (Da):48,980
Last modified:June 1, 1998 - v1
Checksum:i0331125B89CB1A22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038423 Genomic DNA. Translation: AAC46302.1.
LN831039 Genomic DNA. Translation: CKH98101.1.
RefSeqiWP_003895076.1. NZ_LN831039.1.
YP_887924.1. NC_008596.1.

Genome annotation databases

GeneIDi4531957.
KEGGimsm:MSMEG_3621.
PATRICi18079645. VBIMycSme59918_3569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038423 Genomic DNA. Translation: AAC46302.1.
LN831039 Genomic DNA. Translation: CKH98101.1.
RefSeqiWP_003895076.1. NZ_LN831039.1.
YP_887924.1. NC_008596.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_3621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4531957.
KEGGimsm:MSMEG_3621.
PATRICi18079645. VBIMycSme59918_3569.

Phylogenomic databases

eggNOGiENOG4105CEP. Bacteria.
COG1252. LUCA.
KOiK03885.
OrthoDBiEOG6QZMR6.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis."
    Miesel L., Weisbrod T.R., Marcinkeviciene J.A., Bittman R., Jacobs W.R. Jr
    J. Bacteriol. 180:2459-2467(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: mc2155Imported.
  2. Informatics Pathogen
    Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NCTC8159Imported.

Entry informationi

Entry nameiO52473_MYCSM
AccessioniPrimary (citable) accession number: O52473
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.