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O52402

- ALF_EDWI9

UniProt

O52402 - ALF_EDWI9

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Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Edwardsiella ictaluri (strain 93-146)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621Glyceraldehyde 3-phosphateBy similarity
Active sitei109 – 1091Proton donorBy similarity
Metal bindingi110 – 1101Zinc 1; catalyticBy similarity
Metal bindingi144 – 1441Zinc 2By similarity
Metal bindingi174 – 1741Zinc 2By similarity
Metal bindingi226 – 2261Zinc 1; catalyticBy similarity
Binding sitei227 – 2271Dihydroxyacetone phosphate; via amide nitrogenBy similarity
Metal bindingi264 – 2641Zinc 1; catalyticBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciEICT634503:GCMY-3338-MONOMER.
SABIO-RKO52402.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Synonyms:fda
Ordered Locus Names:NT01EI_3367
OrganismiEdwardsiella ictaluri (strain 93-146)
Taxonomic identifieri634503 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEdwardsiella
ProteomesiUP000001485: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Fructose-bisphosphate aldolasePRO_0000178715Add
BLAST

Proteomic databases

PRIDEiO52402.

Interactioni

Protein-protein interaction databases

STRINGi634503.NT01EI_3367.

Structurei

3D structure databases

ProteinModelPortaliO52402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni265 – 2673Dihydroxyacetone phosphate bindingBy similarity
Regioni286 – 2894Dihydroxyacetone phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
HOGENOMiHOG000227794.
KOiK01624.
OMAiHNSLDFV.
OrthoDBiEOG69GZPB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O52402-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKIFDFVKP GVIFGDDVQK VFQVAKENKF ALPAVNCVGT DSINAVMEAA
60 70 80 90 100
AKVRAPIIVQ FSNGGAAFIA GKGLKLEGQQ GAILGAIAGA HHVHQMAEYY
110 120 130 140 150
GVPVILHTDH CAKKLLPWLD GLLDAGEKHF AATGKPLFSS HMIDLSEESL
160 170 180 190 200
EENIEICSQY LARMSKIGMT LELELGCTGG EEDGVDNSHL DNSALYTQPE
210 220 230 240 250
DVDYAFTKLS AISPRFTIAA SFGNVHGVYK PGNVQLTPVI LKNSQEYVSK
260 270 280 290 300
KHNLPHNSLN FVFHGGSGST AAEIKEAVSY GVVKMNIDTD TQWATWEGVL
310 320 330 340 350
KYYKKNEGYL QGQLGNPEGD DKPNKKYYDP RVWLRAAQTG MIERLEQAFK

ELNCIDVL
Length:358
Mass (Da):39,155
Last modified:September 1, 2009 - v2
Checksum:i0EAADF89554D8049
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201K → E in AAB92572. (PubMed:12542086)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF037440 Genomic DNA. Translation: AAB92572.1.
CP001600 Genomic DNA. Translation: ACR70504.1.
RefSeqiWP_015872577.1. NC_012779.2.
YP_002934739.1. NC_012779.2.

Genome annotation databases

EnsemblBacteriaiACR70504; ACR70504; NT01EI_3367.
GeneIDi7959666.
KEGGieic:NT01EI_3367.
PATRICi21839466. VBIEdwIct114273_2993.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF037440 Genomic DNA. Translation: AAB92572.1 .
CP001600 Genomic DNA. Translation: ACR70504.1 .
RefSeqi WP_015872577.1. NC_012779.2.
YP_002934739.1. NC_012779.2.

3D structure databases

ProteinModelPortali O52402.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 634503.NT01EI_3367.

Proteomic databases

PRIDEi O52402.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR70504 ; ACR70504 ; NT01EI_3367 .
GeneIDi 7959666.
KEGGi eic:NT01EI_3367.
PATRICi 21839466. VBIEdwIct114273_2993.

Phylogenomic databases

eggNOGi COG0191.
HOGENOMi HOG000227794.
KOi K01624.
OMAi HNSLDFV.
OrthoDBi EOG69GZPB.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
BioCyci EICT634503:GCMY-3338-MONOMER.
SABIO-RK O52402.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of Edwardsiella ictaluri proteins expressed and recognized by the channel catfish Ictalurus punctatus immune response during infection."
    Moore M.M., Fernandez D.L., Thune R.L.
    Dis. Aquat. Organ. 52:93-107(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete genome sequence of Edwardsiella ictaluri 93-146."
    Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C., Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 93-146.

Entry informationi

Entry nameiALF_EDWI9
AccessioniPrimary (citable) accession number: O52402
Secondary accession number(s): C5BAU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 1, 2009
Last modified: October 1, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3