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O52402

- ALF_EDWI9

UniProt

O52402 - ALF_EDWI9

Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Edwardsiella ictaluri (strain 93-146)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Cofactori

    Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei62 – 621Glyceraldehyde 3-phosphateBy similarity
    Active sitei109 – 1091Proton donorBy similarity
    Metal bindingi110 – 1101Zinc 1; catalyticBy similarity
    Metal bindingi144 – 1441Zinc 2By similarity
    Metal bindingi174 – 1741Zinc 2By similarity
    Metal bindingi226 – 2261Zinc 1; catalyticBy similarity
    Binding sitei227 – 2271Dihydroxyacetone phosphate; via amide nitrogenBy similarity
    Metal bindingi264 – 2641Zinc 1; catalyticBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciEICT634503:GCMY-3338-MONOMER.
    SABIO-RKO52402.
    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase (EC:4.1.2.13)
    Short name:
    FBP aldolase
    Short name:
    FBPA
    Alternative name(s):
    Fructose-1,6-bisphosphate aldolase
    Gene namesi
    Name:fba
    Synonyms:fda
    Ordered Locus Names:NT01EI_3367
    OrganismiEdwardsiella ictaluri (strain 93-146)
    Taxonomic identifieri634503 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEdwardsiella
    ProteomesiUP000001485: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Fructose-bisphosphate aldolasePRO_0000178715Add
    BLAST

    Proteomic databases

    PRIDEiO52402.

    Interactioni

    Protein-protein interaction databases

    STRINGi634503.NT01EI_3367.

    Structurei

    3D structure databases

    ProteinModelPortaliO52402.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni265 – 2673Dihydroxyacetone phosphate bindingBy similarity
    Regioni286 – 2894Dihydroxyacetone phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0191.
    HOGENOMiHOG000227794.
    KOiK01624.
    OMAiHNSLDFV.
    OrthoDBiEOG69GZPB.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR006411. Fruct_bisP_bact.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view]
    PfamiPF01116. F_bP_aldolase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsiTIGR00167. cbbA. 1 hit.
    TIGR01520. FruBisAldo_II_A. 1 hit.
    PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
    PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O52402-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKIFDFVKP GVIFGDDVQK VFQVAKENKF ALPAVNCVGT DSINAVMEAA    50
    AKVRAPIIVQ FSNGGAAFIA GKGLKLEGQQ GAILGAIAGA HHVHQMAEYY 100
    GVPVILHTDH CAKKLLPWLD GLLDAGEKHF AATGKPLFSS HMIDLSEESL 150
    EENIEICSQY LARMSKIGMT LELELGCTGG EEDGVDNSHL DNSALYTQPE 200
    DVDYAFTKLS AISPRFTIAA SFGNVHGVYK PGNVQLTPVI LKNSQEYVSK 250
    KHNLPHNSLN FVFHGGSGST AAEIKEAVSY GVVKMNIDTD TQWATWEGVL 300
    KYYKKNEGYL QGQLGNPEGD DKPNKKYYDP RVWLRAAQTG MIERLEQAFK 350
    ELNCIDVL 358
    Length:358
    Mass (Da):39,155
    Last modified:September 1, 2009 - v2
    Checksum:i0EAADF89554D8049
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201K → E in AAB92572. (PubMed:12542086)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF037440 Genomic DNA. Translation: AAB92572.1.
    CP001600 Genomic DNA. Translation: ACR70504.1.
    RefSeqiWP_015872577.1. NC_012779.2.
    YP_002934739.1. NC_012779.2.

    Genome annotation databases

    EnsemblBacteriaiACR70504; ACR70504; NT01EI_3367.
    GeneIDi7959666.
    KEGGieic:NT01EI_3367.
    PATRICi21839466. VBIEdwIct114273_2993.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF037440 Genomic DNA. Translation: AAB92572.1 .
    CP001600 Genomic DNA. Translation: ACR70504.1 .
    RefSeqi WP_015872577.1. NC_012779.2.
    YP_002934739.1. NC_012779.2.

    3D structure databases

    ProteinModelPortali O52402.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 634503.NT01EI_3367.

    Proteomic databases

    PRIDEi O52402.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACR70504 ; ACR70504 ; NT01EI_3367 .
    GeneIDi 7959666.
    KEGGi eic:NT01EI_3367.
    PATRICi 21839466. VBIEdwIct114273_2993.

    Phylogenomic databases

    eggNOGi COG0191.
    HOGENOMi HOG000227794.
    KOi K01624.
    OMAi HNSLDFV.
    OrthoDBi EOG69GZPB.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .
    BioCyci EICT634503:GCMY-3338-MONOMER.
    SABIO-RK O52402.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR006411. Fruct_bisP_bact.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view ]
    Pfami PF01116. F_bP_aldolase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsi TIGR00167. cbbA. 1 hit.
    TIGR01520. FruBisAldo_II_A. 1 hit.
    PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
    PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of Edwardsiella ictaluri proteins expressed and recognized by the channel catfish Ictalurus punctatus immune response during infection."
      Moore M.M., Fernandez D.L., Thune R.L.
      Dis. Aquat. Organ. 52:93-107(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete genome sequence of Edwardsiella ictaluri 93-146."
      Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C., Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 93-146.

    Entry informationi

    Entry nameiALF_EDWI9
    AccessioniPrimary (citable) accession number: O52402
    Secondary accession number(s): C5BAU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3