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Protein

1,2-dihydroxy-1,2-dihydronaphthalene dehydrogenase

Gene

nagB

Organism
Ralstonia sp.
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of naphthalene dihydrodiol into 1,2-dihydroxynaphthalene.1 Publication

Catalytic activityi

(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH.By similarity

Pathwayi: naphthalene degradation

This protein is involved in the pathway naphthalene degradation, which is part of Aromatic compound metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway naphthalene degradation and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei58NADBy similarity1
Binding sitei140SubstrateBy similarity1
Active sitei153Proton acceptorBy similarity1
Binding sitei157NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 35NADBy similarityAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00082.

Names & Taxonomyi

Protein namesi
Recommended name:
1,2-dihydroxy-1,2-dihydronaphthalene dehydrogenaseBy similarity (EC:1.3.1.29By similarity)
Alternative name(s):
Cis-naphthalene dihydrodiol dehydrogenase1 Publication
Gene namesi
Name:nagBImported
Encoded oniPlasmid pWWU2Imported
OrganismiRalstonia sp.
Taxonomic identifieri54061 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004202371 – 2591,2-dihydroxy-1,2-dihydronaphthalene dehydrogenaseAdd BLAST259

Structurei

3D structure databases

ProteinModelPortaliO52384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

O52384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIQQVIAIT GAGSGIGLEL VRSFKAAGYC VSALVRNEEQ EAGLRSEFKD
60 70 80 90 100
AIEIVAGDVC DHATNEKLVN KAVARFGHLD CFIGNAGIWD YMLGVDEPWE
110 120 130 140 150
KLSGSFEEIF DINVKSYFSG ISAALPELKK TNGSVVVTAS VSSYAAGGGG
160 170 180 190 200
SCYIASKHAV LGMVKALAYE LAPHIRVNGV APGGTVTSLA GPASAGFDKT
210 220 230 240 250
KMKDMPGIDD MIKGLTPLGF AARPEDVVAP YLLLASREQG KFITGTVIGI

DGGMALGRK
Length:259
Mass (Da):27,062
Last modified:November 1, 1998 - v2
Checksum:i50011B273350BFD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036940 Genomic DNA. Translation: AAD12612.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036940 Genomic DNA. Translation: AAD12612.1.

3D structure databases

ProteinModelPortaliO52384.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00082.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNAGB_RALSP
AccessioniPrimary (citable) accession number: O52384
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.