O52376 (DSBA_PSESM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiol:disulfide interchange protein DsbA

Gene names

Name:	dsbA
Ordered Locus Names:	PSPTO_0341

Organism

Pseudomonas syringae pv. tomato (strain DC3000) [Complete proteome] [HAMAP]

Taxonomic identifier

223283 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins By similarity.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbA subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 214	192	Thiol:disulfide interchange protein DsbA		PRO_0000034263
Regions
	Domain	23 – 154	132	Thioredoxin
Amino acid modifications
	Disulfide bond	57 ↔ 60		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	O52376 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 92F7DB1F31A6996B	FASTA	214	23,340
	10 20 30 40 50 60 MRNLIISAAL VAASLFGMSA QAAEPIESGK QYVELTSAVP VAVPGKIEVI ELFWYGCPHC 70 80 90 100 110 120 YAFEPTINPW VEKLPSDVNF VRIPAMFGGP WDAHGQLFIT LDTMGVEHKV HAAVFEAIQK 130 140 150 160 170 180 GGKRLTDKND MADFVATQGV NKDDFLKTFD SFAVKGKIAQ YKELAKKYEV TGVPTMIVNG 190 200 210 KYRFDLGSAG GPEKTLQVAD QLIDKERAAA KAAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Kloek A.P., Kunkel B.N. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete genome sequence of the Arabidopsis and tomato pathogen Pseudomonas syringae pv. tomato DC3000." Buell C.R., Joardar V., Lindeberg M., Selengut J., Paulsen I.T., Gwinn M.L., Dodson R.J., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Daugherty S.C., Brinkac L.M., Beanan M.J., Haft D.H., Nelson W.C., Davidsen T.M., Zafar N. , Zhou L., Liu J., Yuan Q., Khouri H.M., Fedorova N.B., Tran B., Russell D., Berry K.J., Utterback T.R., Van Aken S.E., Feldblyum T.V., D'Ascenzo M., Deng W.-L., Ramos A.R., Alfano J.R., Cartinhour S., Chatterjee A.K., Delaney T.P., Lazarowitz S.G., Martin G.B., Schneider D.J., Tang X., Bender C.L., White O., Fraser C.M., Collmer A. Proc. Natl. Acad. Sci. U.S.A. 100:10181-10186(2003) [PubMed: 12928499] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DC3000.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF036929 Genomic DNA. Translation: AAB92367.1. AE016853 Genomic DNA. Translation: AAO53886.1.
RefSeq	NP_790191.1. NC_004578.1.
3D structure databases
ProteinModelPortal	O52376.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1181950.
GenomeReviews	Gene locus PSPTO_0341 in contig AE016853_GR.
KEGG	pst:PSPTO_0341.
NMPDR	fig|223283.1.peg.329.
PATRIC	19991858. VBIPseSyr93040_0357.
TIGR	PSPTO_0341.
Phylogenomic databases
HOGENOM	HBG680642.
OMA	NDMAVPM.
ProtClustDB	CLSK869391.
Enzyme and pathway databases
BioCyc	PSYR223283:PSPTO_0341-MONOMER.
BRENDA	1.8.4.2. 5193.
Family and domain databases
InterPro	IPR001853. DSBA-like_thioredoxin_dom. IPR023205. Thiol:disulphide_interchange. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 2 hits.
KO	K03673.
Pfam	PF01323. DSBA. 1 hit. [Graphical view]
PIRSF	PIRSF001488. Tdi_protein. 1 hit.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBA_PSESM

Accession

Primary (citable) accession number: O52376

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program