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Protein

L-lactate dehydrogenase

Gene

ldh

Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of lactate to pyruvate.UniRule annotation

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12NAD; via amide nitrogenUniRule annotation1
Binding sitei33NADUniRule annotation1
Binding sitei65NADUniRule annotation1
Binding sitei94SubstrateUniRule annotation1
Binding sitei149NADUniRule annotation1
Active sitei181Proton acceptorUniRule annotation1
Binding sitei234SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciMGAL710127:G1GL5-92-MONOMER
UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDHUniRule annotation
Gene namesi
Name:ldhUniRule annotation
Synonyms:mdh
Ordered Locus Names:MYCGA0730
ORF Names:MGA_0746
OrganismiMycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Taxonomic identifieri710127 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000001418 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001683671 – 323L-lactate dehydrogenaseAdd BLAST323

Proteomic databases

PRIDEiO52354

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO52354
SMRiO52354
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 129Substrate bindingUniRule annotation4
Regioni154 – 157Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotationCurated

Phylogenomic databases

HOGENOMiHOG000213793
KOiK00016
OMAiMDLMQTA

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit

Sequencei

Sequence statusi: Complete.

O52354-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIAVIGCG FVGSTYILDL LQQGVQADYL LVDKNTNLAD GHVRDLRDSK
60 70 80 90 100
SLKSHNGSTF NVGTYDDLKD ADVVAITASI PTVPTADGEV FTDRLQLMTA
110 120 130 140 150
NVKILNEIAL ELKRVGFKGL SIIPTNPCDV MAGVYQKVTG FDPHKIISTG
160 170 180 190 200
CQLETMRTRK MISEALGVNS DSVEGFVVGE HGSGAIVPWS VFRVGNVPMK
210 220 230 240 250
QLIAEGKIKE EYVKDIFSRV VKEAFEIIKF KKATYFGIAE SMSLITRAYI
260 270 280 290 300
YNLNTVLGVG VQLDDKYVAS GIYFTVPAVV GKHGWKLHSK LQLSQEEQAA
310 320
FDKSALNIQK VTKDALDLIG FKN
Length:323
Mass (Da):35,372
Last modified:August 15, 2003 - v2
Checksum:i6831D412F214C5E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218S → P in AAB95409 (PubMed:10867916).Curated1
Sequence conflicti255T → M in AAB95409 (PubMed:10867916).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036708 Genomic DNA Translation: AAB95409.1
AE015450 Genomic DNA Translation: AAP56423.1
RefSeqiWP_011113302.1, NC_004829.2

Genome annotation databases

EnsemblBacteriaiAAP56423; AAP56423; MGA_0746
GeneIDi1090122
KEGGimga:MGA_0746
PATRICifig|233150.7.peg.77

Similar proteinsi

Entry informationi

Entry nameiLDH_MYCGA
AccessioniPrimary (citable) accession number: O52354
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 15, 2003
Last modified: May 23, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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