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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciMGAL710127:GC09-71-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Gene namesi
Name:secYUniRule annotation
Synonyms:recY
Ordered Locus Names:MYCGA0700
ORF Names:MGA_0740
OrganismiMycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Taxonomic identifieri710127 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000001418 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321HelicalUniRule annotationAdd
BLAST
Transmembranei65 – 8723HelicalUniRule annotationAdd
BLAST
Transmembranei124 – 14421HelicalUniRule annotationAdd
BLAST
Transmembranei163 – 18321HelicalUniRule annotationAdd
BLAST
Transmembranei191 – 21121HelicalUniRule annotationAdd
BLAST
Transmembranei229 – 24921HelicalUniRule annotationAdd
BLAST
Transmembranei281 – 30121HelicalUniRule annotationAdd
BLAST
Transmembranei322 – 34221HelicalUniRule annotationAdd
BLAST
Transmembranei382 – 40221HelicalUniRule annotationAdd
BLAST
Transmembranei406 – 42621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Protein translocase subunit SecYPRO_0000131734Add
BLAST

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO52351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000080586.
KOiK03076.
OMAiQTYVISQ.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O52351-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKTNSKNLL GQKIIKLLRN RDFVISVFVT LFLILLFRVI SVIPLPGITI
60 70 80 90 100
SQNKNNLNNG VSDFFDLFNL LGGGGLSQLS LFAVGISPYI SAQIIMQLLS
110 120 130 140 150
TDLIPPLSKL AKSGELGRRR IELITRFVTL PFAVVQAFAI IALINNQRNG
160 170 180 190 200
AIRFENGGIL HQAFYIVTMT AGTYIGIFIG DIISKKGVGN GITLLILSGI
210 220 230 240 250
LARLPDGFIV MYRVLGGVII STNPILTSAI NFSLYFLAFL VLLLAISFVN
260 270 280 290 300
SSTRRIPIQQ TGEGMVLGNE KLPYLPIKLN AAGVIPVIFA SSIMSIPITI
310 320 330 340 350
AEFQPQSEAR WFVEDYLSLR TPVGISLYVI LIIIFTFFYS YIQINPEQLA
360 370 380 390 400
ENFNKSHKFI PGVRPGLDTE KHITKVLMRI NFIGAPFLAI VAVIPYIISL
410 420 430 440 450
VLNVPTTLSL GGTGIIIMVS ASMELYRSLR SAATTTSYQR LRKDIANRIE
460 470 480 490
AELSLNDYMN KPNLEHDQYG LLGQHKKVEP TQDKKKNPSD PLEVSQLW
Length:498
Mass (Da):55,045
Last modified:August 15, 2003 - v2
Checksum:i2EB3ED5FD63CE1F2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131K → R in AAB95406 (PubMed:10867916).Curated
Sequence conflicti247 – 2471S → T in AAB95406 (PubMed:10867916).Curated
Sequence conflicti330 – 3301I → V in AAB95406 (PubMed:10867916).Curated
Sequence conflicti451 – 4511A → V in AAB95406 (PubMed:10867916).Curated
Sequence conflicti474 – 4741Q → K in AAB95406 (PubMed:10867916).Curated
Sequence conflicti490 – 4901D → N in AAB95406 (PubMed:10867916).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036708 Genomic DNA. Translation: AAB95406.1.
AE015450 Genomic DNA. Translation: AAP56420.1.
RefSeqiWP_011113299.1. NC_004829.2.

Genome annotation databases

EnsemblBacteriaiAAP56420; AAP56420; MGA_0740.
GeneIDi1090119.
KEGGimga:MGA_0740.
PATRICi20007812. VBIMycGal115357_0074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036708 Genomic DNA. Translation: AAB95406.1.
AE015450 Genomic DNA. Translation: AAP56420.1.
RefSeqiWP_011113299.1. NC_004829.2.

3D structure databases

ProteinModelPortaliO52351.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP56420; AAP56420; MGA_0740.
GeneIDi1090119.
KEGGimga:MGA_0740.
PATRICi20007812. VBIMycGal115357_0074.

Phylogenomic databases

HOGENOMiHOG000080586.
KOiK03076.
OMAiQTYVISQ.

Enzyme and pathway databases

BioCyciMGAL710127:GC09-71-MONOMER.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECY_MYCGA
AccessioniPrimary (citable) accession number: O52351
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 15, 2003
Last modified: September 7, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.