Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O52326

- ARND_SALTY

UniProt

O52326 - ARND_SALTY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

Gene

arnD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (Probable).1 Publication

Catalytic activityi

4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: UniProtKB-HAMAP

GO - Biological processi

  1. 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. lipid A biosynthetic process Source: UniProtKB-HAMAP
  3. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
  4. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciSENT99287:GCTI-2315-MONOMER.
UniPathwayiUPA00030.
UPA00036; UER00496.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDUniRule annotation (EC:3.5.1.n3UniRule annotation)
Gene namesi
Name:arnDUniRule annotation
Synonyms:pbgP4, pmrJ
Ordered Locus Names:STM2300
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDPRO_0000169177Add
BLAST

Proteomic databases

PRIDEiO52326.

Expressioni

Inductioni

Induced by BasR.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2300.

Structurei

3D structure databases

ProteinModelPortaliO52326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 260259NodB homologyUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.UniRule annotation
Contains 1 NodB homology domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261199.
KOiK13014.
OMAiLHAWDHF.
OrthoDBiEOG6423D0.
PhylomeDBiO52326.

Family and domain databases

Gene3Di3.20.20.370. 2 hits.
HAMAPiMF_01870. ArnD.
InterProiIPR023557. ArnD.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. Polysac_deacetylase.
[Graphical view]
PfamiPF01522. Polysacc_deac_1. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 2 hits.
PROSITEiPS51677. NODB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O52326-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKVGLRIDV DTLRGTREGV PRLLATLHRH GVQASFFFSV GPDNMGRHLW
60 70 80 90 100
RLIKPRFLWK MLRSNAASLY GWDILLAGTA WPGKNIGNAN AGIIRETATY
110 120 130 140 150
HETGLHAWDH HAWQTHSGHW SIRQLEEDIA RGITALEAII GKPVTCSAAA
160 170 180 190 200
GWRADGRVVR AKESFNLRYN SDCRGTTLFR PLLMPGQTGT PQIPVTLPTW
210 220 230 240 250
DEVIGPAVQA QSFNTWIISR MLQDKGTPVY TIHAEVEGIV HQPLFEDLLV
260 270 280 290
RARDAGITFC PLGELLPASP ESLPLGQIVR GHIPGREGWL GCQQAASAS
Length:299
Mass (Da):33,010
Last modified:June 1, 1998 - v1
Checksum:i5A33F6D1D494859F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036677 Genomic DNA. Translation: AAC04773.1.
AE006468 Genomic DNA. Translation: AAL21201.1.
RefSeqiNP_461242.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21201; AAL21201; STM2300.
GeneIDi1253822.
KEGGistm:STM2300.
PATRICi32383211. VBISalEnt20916_2435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036677 Genomic DNA. Translation: AAC04773.1 .
AE006468 Genomic DNA. Translation: AAL21201.1 .
RefSeqi NP_461242.1. NC_003197.1.

3D structure databases

ProteinModelPortali O52326.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM2300.

Proteomic databases

PRIDEi O52326.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL21201 ; AAL21201 ; STM2300 .
GeneIDi 1253822.
KEGGi stm:STM2300.
PATRICi 32383211. VBISalEnt20916_2435.

Phylogenomic databases

HOGENOMi HOG000261199.
KOi K13014.
OMAi LHAWDHF.
OrthoDBi EOG6423D0.
PhylomeDBi O52326.

Enzyme and pathway databases

UniPathwayi UPA00030 .
UPA00036 ; UER00496 .
BioCyci SENT99287:GCTI-2315-MONOMER.

Family and domain databases

Gene3Di 3.20.20.370. 2 hits.
HAMAPi MF_01870. ArnD.
InterProi IPR023557. ArnD.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. Polysac_deacetylase.
[Graphical view ]
Pfami PF01522. Polysacc_deac_1. 1 hit.
[Graphical view ]
SUPFAMi SSF88713. SSF88713. 2 hits.
PROSITEi PS51677. NODB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance."
    Gunn J.S., Lim K.B., Krueger J., Kim K., Guo L., Hackett M., Miller S.I.
    Mol. Microbiol. 27:1171-1182(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 14028s / SGSG 2262.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  3. "Molecular characterization of the PmrA regulon."
    Woesten M.M.S.M., Groisman E.A.
    J. Biol. Chem. 274:27185-27190(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: ATCC 14028s / SGSG 2262.
  4. "Genetic and functional analysis of a PmrA-PmrB-regulated locus necessary for lipopolysaccharide modification, antimicrobial peptide resistance, and oral virulence of Salmonella enterica serovar typhimurium."
    Gunn J.S., Ryan S.S., Van Velkinburgh J.C., Ernst R.K., Miller S.I.
    Infect. Immun. 68:6139-6146(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN POLYMYXIN RESISTANCE.
    Strain: ATCC 14028s / SGSG 2262.

Entry informationi

Entry nameiARND_SALTY
AccessioniPrimary (citable) accession number: O52326
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: June 1, 1998
Last modified: October 1, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3