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O52326

- ARND_SALTY

UniProt

O52326 - ARND_SALTY

Protein

Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

Gene

arnD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides Probable.1 Publication

    Catalytic activityi

    4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process Source: UniProtKB-UniPathway
    2. lipid A biosynthetic process Source: UniProtKB-HAMAP
    3. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
    4. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-2315-MONOMER.
    UniPathwayiUPA00030.
    UPA00036; UER00496.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDUniRule annotation (EC:3.5.1.n3UniRule annotation)
    Gene namesi
    Name:arnDUniRule annotation
    Synonyms:pbgP4, pmrJ
    Ordered Locus Names:STM2300
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDPRO_0000169177Add
    BLAST

    Proteomic databases

    PRIDEiO52326.

    Expressioni

    Inductioni

    Induced by BasR.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM2300.

    Structurei

    3D structure databases

    ProteinModelPortaliO52326.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 260259NodB homologyUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.UniRule annotation
    Contains 1 NodB homology domain.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000261199.
    KOiK13014.
    OMAiLHAWDHF.
    OrthoDBiEOG6423D0.
    PhylomeDBiO52326.

    Family and domain databases

    Gene3Di3.20.20.370. 2 hits.
    HAMAPiMF_01870. ArnD.
    InterProiIPR023557. ArnD.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR002509. Polysac_deacetylase.
    [Graphical view]
    PfamiPF01522. Polysacc_deac_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF88713. SSF88713. 2 hits.
    PROSITEiPS51677. NODB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O52326-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKVGLRIDV DTLRGTREGV PRLLATLHRH GVQASFFFSV GPDNMGRHLW    50
    RLIKPRFLWK MLRSNAASLY GWDILLAGTA WPGKNIGNAN AGIIRETATY 100
    HETGLHAWDH HAWQTHSGHW SIRQLEEDIA RGITALEAII GKPVTCSAAA 150
    GWRADGRVVR AKESFNLRYN SDCRGTTLFR PLLMPGQTGT PQIPVTLPTW 200
    DEVIGPAVQA QSFNTWIISR MLQDKGTPVY TIHAEVEGIV HQPLFEDLLV 250
    RARDAGITFC PLGELLPASP ESLPLGQIVR GHIPGREGWL GCQQAASAS 299
    Length:299
    Mass (Da):33,010
    Last modified:June 1, 1998 - v1
    Checksum:i5A33F6D1D494859F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF036677 Genomic DNA. Translation: AAC04773.1.
    AE006468 Genomic DNA. Translation: AAL21201.1.
    RefSeqiNP_461242.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL21201; AAL21201; STM2300.
    GeneIDi1253822.
    KEGGistm:STM2300.
    PATRICi32383211. VBISalEnt20916_2435.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF036677 Genomic DNA. Translation: AAC04773.1 .
    AE006468 Genomic DNA. Translation: AAL21201.1 .
    RefSeqi NP_461242.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali O52326.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM2300.

    Proteomic databases

    PRIDEi O52326.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL21201 ; AAL21201 ; STM2300 .
    GeneIDi 1253822.
    KEGGi stm:STM2300.
    PATRICi 32383211. VBISalEnt20916_2435.

    Phylogenomic databases

    HOGENOMi HOG000261199.
    KOi K13014.
    OMAi LHAWDHF.
    OrthoDBi EOG6423D0.
    PhylomeDBi O52326.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    UPA00036 ; UER00496 .
    BioCyci SENT99287:GCTI-2315-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.370. 2 hits.
    HAMAPi MF_01870. ArnD.
    InterProi IPR023557. ArnD.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR002509. Polysac_deacetylase.
    [Graphical view ]
    Pfami PF01522. Polysacc_deac_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF88713. SSF88713. 2 hits.
    PROSITEi PS51677. NODB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance."
      Gunn J.S., Lim K.B., Krueger J., Kim K., Guo L., Hackett M., Miller S.I.
      Mol. Microbiol. 27:1171-1182(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 14028s / SGSG 2262.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.
    3. "Molecular characterization of the PmrA regulon."
      Woesten M.M.S.M., Groisman E.A.
      J. Biol. Chem. 274:27185-27190(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
      Strain: ATCC 14028s / SGSG 2262.
    4. "Genetic and functional analysis of a PmrA-PmrB-regulated locus necessary for lipopolysaccharide modification, antimicrobial peptide resistance, and oral virulence of Salmonella enterica serovar typhimurium."
      Gunn J.S., Ryan S.S., Van Velkinburgh J.C., Ernst R.K., Miller S.I.
      Infect. Immun. 68:6139-6146(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN POLYMYXIN RESISTANCE.
      Strain: ATCC 14028s / SGSG 2262.

    Entry informationi

    Entry nameiARND_SALTY
    AccessioniPrimary (citable) accession number: O52326
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3