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O52177

- RELA_MYXXA

UniProt

O52177 - RELA_MYXXA

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Protein

GTP pyrophosphokinase

Gene
relA
Organism
Myxococcus xanthus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp By similarity.

Catalytic activityi

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathwayi

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. GTP binding Source: UniProtKB-KW
  4. GTP diphosphokinase activity Source: UniProtKB-EC
  5. kinase activity Source: UniProtKB-KW
  6. metal ion binding Source: InterPro
  7. phosphoric diester hydrolase activity Source: InterPro

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP pyrophosphokinase (EC:2.7.6.5)
Alternative name(s):
(p)ppGpp synthase
ATP:GTP 3'-pyrophosphotransferase
ppGpp synthase I
Gene namesi
Name:relA
OrganismiMyxococcus xanthus
Taxonomic identifieri34 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757GTP pyrophosphokinasePRO_0000166553Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO52177.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 165103HDAdd
BLAST
Domaini685 – 75773ACTAdd
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.
Contains 1 ACT domain.
Contains 1 HD domain.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O52177-1 [UniParc]FASTAAdd to Basket

« Hide

MWGNVAPPLV QSYDCSSFDD SPERHPPTVS QYHPDPDLDI IKKAYVYSAK    50
VHQGQLRKSG EPYLVHPLEV AGILGELKLD EASIVTGLLH DTIEDTLATE 100
EELTELFGSE VAHLVDGVTK LSKFSASASL SQEEKQAENF RKMIIAMAQD 150
IRVILVKLAD RTHNMRTLDH MSEEKQARIA QETLDIYAPL ANRLGISWIK 200
TELEDLSFRY VKPQEFFALQ AKLNKRKKER EKYIEDTCDL IRSKLAERGL 250
KGEVSGRFKH VYSIYKKIKS QGIDFDQIHD IIAFRIIAPT APSCYEALGL 300
VHEMWKPVPG RFKDFIAIPK PNMYQSLHTT IIGPLSERVE VQIRTSEMHK 350
IAEEGIAAHW KYKEGKAVIS KDDEKFAWLR QLMEWQQDLK DPKEFLETVK 400
VDLFTDEVFV FTPKGDVRSL PRGATPVDFA YAIHSDVGNR CVGAKVNGKI 450
VPLRYKMKNG DTVEVLTSPQ QHPSKDWLTF VKTSRAQQRI RGFIKQQQRE 500
KSLQLGRELA DRELKRFQLN FNRLLKSGEM KKAAVDLGFR VEDDMLVAIG 550
YGKVTPQQLS HRLVPQEKLN AAEAGGRADA NPAATTSGGA GNSVLPGLSR 600
VTDLAKRLVG RSNRSGVQIG GVDDVLVRFG RCCNPVPGDP IAGFITRGRG 650
VTVHTVGCEK ALATDPERRV DVSWDVRGDF KRPVTLRVLT ADRPGLLADI 700
TNTFSKKGVN ISQANCRATG DDRAVNTFEV IISDLKQLTD LMRTIERLQG 750
VYSVERI 757
Length:757
Mass (Da):84,978
Last modified:June 1, 1998 - v1
Checksum:iD6CC1000A5F72A7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF025847 Genomic DNA. Translation: AAB97677.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF025847 Genomic DNA. Translation: AAB97677.1 .

3D structure databases

ProteinModelPortali O52177.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
SUPFAMi SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The guanosine nucleotide (p)ppGpp initiates development and A-factor production in Myxococcus xanthus."
    Harris B.Z., Kaiser D., Singer M.H.
    Genes Dev. 12:1022-1035(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DK101.

Entry informationi

Entry nameiRELA_MYXXA
AccessioniPrimary (citable) accession number: O52177
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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