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O52177

- RELA_MYXXA

UniProt

O52177 - RELA_MYXXA

Protein

GTP pyrophosphokinase

Gene

relA

Organism
Myxococcus xanthus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp By similarity.By similarity

    Catalytic activityi

    ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

    Pathwayi

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. GTP binding Source: UniProtKB-KW
    4. GTP diphosphokinase activity Source: UniProtKB-EC
    5. kinase activity Source: UniProtKB-KW
    6. metal ion binding Source: InterPro
    7. phosphoric diester hydrolase activity Source: InterPro

    GO - Biological processi

    1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP pyrophosphokinase (EC:2.7.6.5)
    Alternative name(s):
    (p)ppGpp synthase
    ATP:GTP 3'-pyrophosphotransferase
    ppGpp synthase I
    Gene namesi
    Name:relA
    OrganismiMyxococcus xanthus
    Taxonomic identifieri34 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 757757GTP pyrophosphokinasePRO_0000166553Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO52177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini63 – 165103HDAdd
    BLAST
    Domaini685 – 75773ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RelA/SpoT family.Curated
    Contains 1 ACT domain.PROSITE-ProRule annotation
    Contains 1 HD domain.Curated

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR002912. ACT_dom.
    IPR012675. Beta-grasp_dom.
    IPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view]
    PfamiPF01842. ACT. 1 hit.
    PF01966. HD. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view]
    SMARTiSM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view]
    SUPFAMiSSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O52177-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWGNVAPPLV QSYDCSSFDD SPERHPPTVS QYHPDPDLDI IKKAYVYSAK    50
    VHQGQLRKSG EPYLVHPLEV AGILGELKLD EASIVTGLLH DTIEDTLATE 100
    EELTELFGSE VAHLVDGVTK LSKFSASASL SQEEKQAENF RKMIIAMAQD 150
    IRVILVKLAD RTHNMRTLDH MSEEKQARIA QETLDIYAPL ANRLGISWIK 200
    TELEDLSFRY VKPQEFFALQ AKLNKRKKER EKYIEDTCDL IRSKLAERGL 250
    KGEVSGRFKH VYSIYKKIKS QGIDFDQIHD IIAFRIIAPT APSCYEALGL 300
    VHEMWKPVPG RFKDFIAIPK PNMYQSLHTT IIGPLSERVE VQIRTSEMHK 350
    IAEEGIAAHW KYKEGKAVIS KDDEKFAWLR QLMEWQQDLK DPKEFLETVK 400
    VDLFTDEVFV FTPKGDVRSL PRGATPVDFA YAIHSDVGNR CVGAKVNGKI 450
    VPLRYKMKNG DTVEVLTSPQ QHPSKDWLTF VKTSRAQQRI RGFIKQQQRE 500
    KSLQLGRELA DRELKRFQLN FNRLLKSGEM KKAAVDLGFR VEDDMLVAIG 550
    YGKVTPQQLS HRLVPQEKLN AAEAGGRADA NPAATTSGGA GNSVLPGLSR 600
    VTDLAKRLVG RSNRSGVQIG GVDDVLVRFG RCCNPVPGDP IAGFITRGRG 650
    VTVHTVGCEK ALATDPERRV DVSWDVRGDF KRPVTLRVLT ADRPGLLADI 700
    TNTFSKKGVN ISQANCRATG DDRAVNTFEV IISDLKQLTD LMRTIERLQG 750
    VYSVERI 757
    Length:757
    Mass (Da):84,978
    Last modified:June 1, 1998 - v1
    Checksum:iD6CC1000A5F72A7B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF025847 Genomic DNA. Translation: AAB97677.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF025847 Genomic DNA. Translation: AAB97677.1 .

    3D structure databases

    ProteinModelPortali O52177.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR002912. ACT_dom.
    IPR012675. Beta-grasp_dom.
    IPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view ]
    Pfami PF01842. ACT. 1 hit.
    PF01966. HD. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view ]
    SMARTi SM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The guanosine nucleotide (p)ppGpp initiates development and A-factor production in Myxococcus xanthus."
      Harris B.Z., Kaiser D., Singer M.H.
      Genes Dev. 12:1022-1035(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DK101.

    Entry informationi

    Entry nameiRELA_MYXXA
    AccessioniPrimary (citable) accession number: O52177
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3