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Protein

Neutral endopeptidase

Gene

pepO

Organism
Lactobacillus helveticus (Lactobacillus suntoryeus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi496Zinc; catalyticPROSITE-ProRule annotation1
Active sitei497PROSITE-ProRule annotation1
Metal bindingi500Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi556Zinc; catalyticPROSITE-ProRule annotation1
Active sitei560Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM13.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral endopeptidase (EC:3.4.24.-)
Alternative name(s):
Endopeptidase O
Gene namesi
Name:pepO
OrganismiLactobacillus helveticus (Lactobacillus suntoryeus)
Taxonomic identifieri1587 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000782321 – 647Neutral endopeptidaseAdd BLAST647

Proteomic databases

PRIDEiO52071.

Structurei

3D structure databases

ProteinModelPortaliO52071.
SMRiO52071.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M13 family.Curated

Phylogenomic databases

eggNOGiENOG4105C9K. Bacteria.
COG3590. LUCA.

Family and domain databases

CDDicd08662. M13. 1 hit.
Gene3Di3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR024079. MetalloPept_cat_dom_sf.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
PANTHERiPTHR11733. PTHR11733. 1 hit.
PfamiView protein in Pfam
PF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
PRINTSiPR00786. NEPRILYSIN.
PROSITEiView protein in PROSITE
PS00142. ZINC_PROTEASE. 1 hit.

Sequencei

Sequence statusi: Complete.

O52071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRYLAVRGG AGDVAEPDLN AKPQDNLYLA VNSEWLSKAE IPADQTSAGV
60 70 80 90 100
NTELDIKIEK RMMKDFADIA SGKEKMPDIR DFDKAIALYK IAKNFDKRDA
110 120 130 140 150
EKANPIQNDL QKILDLINFD KFKDNATELF MGPYALPFVF DVDADMKNTD
160 170 180 190 200
FNVLHFGGPS TFLPDTTTYK TPEAKKLLDI LEKQSINLLE MAGIGKEEAR
210 220 230 240 250
VYVQNALAFD QKLSKVVKST EEWSDYAAIY NPVSLTEFLA KFKSFDMADF
260 270 280 290 300
LKTILPEKVE RVIVMEPRFL DHADELINPA NFDEIKGWML VKYINSVAKY
310 320 330 340 350
LSQDFRAAAF PFNQAISGTP ELPSQIKQAY RLANGAFDEA VGIFYGKKYF
360 370 380 390 400
GEEAKHDVED MIHNMLKVYE QRINDNNWLS EDTKKKAIIK LRALVLKIGY
410 420 430 440 450
PEKIEKIYDL LQIDPERSLY ENEAQMATVR TKYMLDKLTQ PVDRSVWLMP
460 470 480 490 500
GNLNNACYDP QRNDLTFPAG ILQAPFYDIH QSRGANYGGI GATIGHEVSH
510 520 530 540 550
AFDNSGAKFD EHGNMNNWWT DEDFAEFNKR VGQMVDIFDG LQYGPAKING
560 570 580 590 600
KQVVGENIAD LAGLACAVQA GKNDNVDLKD LFENYARSWM QKQRPEAIKT
610 620 630 640
EVQVDVHAPQ PTRVNIPVQC QDDFYTAFDV KPDDGMWLDP EDRITIW
Length:647
Mass (Da):73,537
Last modified:June 1, 1998 - v1
Checksum:iEB5153C5E1DDE6FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019410 Genomic DNA. Translation: AAC35997.1.
RefSeqiWP_003629024.1. NZ_LSVJ01000016.1.

Similar proteinsi

Entry informationi

Entry nameiPEPO_LACHE
AccessioniPrimary (citable) accession number: O52071
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: February 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program