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Protein

Neutral endopeptidase

Gene

pepO

Organism
Lactobacillus helveticus (Lactobacillus suntoryeus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi496 – 4961Zinc; catalyticPROSITE-ProRule annotation
Active sitei497 – 4971PROSITE-ProRule annotation
Metal bindingi500 – 5001Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi556 – 5561Zinc; catalyticPROSITE-ProRule annotation
Active sitei560 – 5601Proton donorPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM13.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral endopeptidase (EC:3.4.24.-)
Alternative name(s):
Endopeptidase O
Gene namesi
Name:pepO
OrganismiLactobacillus helveticus (Lactobacillus suntoryeus)
Taxonomic identifieri1587 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 647647Neutral endopeptidasePRO_0000078232Add
BLAST

Proteomic databases

PRIDEiO52071.

Interactioni

Protein-protein interaction databases

STRINGi405566.lhv_1360.

Structurei

3D structure databases

ProteinModelPortaliO52071.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M13 family.Curated

Phylogenomic databases

eggNOGiENOG4105C9K. Bacteria.
COG3590. LUCA.

Family and domain databases

CDDicd08662. M13. 1 hit.
Gene3Di3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 1 hit.
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O52071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRYLAVRGG AGDVAEPDLN AKPQDNLYLA VNSEWLSKAE IPADQTSAGV
60 70 80 90 100
NTELDIKIEK RMMKDFADIA SGKEKMPDIR DFDKAIALYK IAKNFDKRDA
110 120 130 140 150
EKANPIQNDL QKILDLINFD KFKDNATELF MGPYALPFVF DVDADMKNTD
160 170 180 190 200
FNVLHFGGPS TFLPDTTTYK TPEAKKLLDI LEKQSINLLE MAGIGKEEAR
210 220 230 240 250
VYVQNALAFD QKLSKVVKST EEWSDYAAIY NPVSLTEFLA KFKSFDMADF
260 270 280 290 300
LKTILPEKVE RVIVMEPRFL DHADELINPA NFDEIKGWML VKYINSVAKY
310 320 330 340 350
LSQDFRAAAF PFNQAISGTP ELPSQIKQAY RLANGAFDEA VGIFYGKKYF
360 370 380 390 400
GEEAKHDVED MIHNMLKVYE QRINDNNWLS EDTKKKAIIK LRALVLKIGY
410 420 430 440 450
PEKIEKIYDL LQIDPERSLY ENEAQMATVR TKYMLDKLTQ PVDRSVWLMP
460 470 480 490 500
GNLNNACYDP QRNDLTFPAG ILQAPFYDIH QSRGANYGGI GATIGHEVSH
510 520 530 540 550
AFDNSGAKFD EHGNMNNWWT DEDFAEFNKR VGQMVDIFDG LQYGPAKING
560 570 580 590 600
KQVVGENIAD LAGLACAVQA GKNDNVDLKD LFENYARSWM QKQRPEAIKT
610 620 630 640
EVQVDVHAPQ PTRVNIPVQC QDDFYTAFDV KPDDGMWLDP EDRITIW
Length:647
Mass (Da):73,537
Last modified:June 1, 1998 - v1
Checksum:iEB5153C5E1DDE6FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019410 Genomic DNA. Translation: AAC35997.1.
RefSeqiWP_003629024.1. NZ_LSVJ01000016.1.

Genome annotation databases

GeneIDi16794377.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019410 Genomic DNA. Translation: AAC35997.1.
RefSeqiWP_003629024.1. NZ_LSVJ01000016.1.

3D structure databases

ProteinModelPortaliO52071.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi405566.lhv_1360.

Protein family/group databases

MEROPSiM13.010.

Proteomic databases

PRIDEiO52071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16794377.

Phylogenomic databases

eggNOGiENOG4105C9K. Bacteria.
COG3590. LUCA.

Family and domain databases

CDDicd08662. M13. 1 hit.
Gene3Di3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 1 hit.
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEPO_LACHE
AccessioniPrimary (citable) accession number: O52071
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.