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Protein

Flagellar M-ring protein

Gene

fliF

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The M ring may be actively involved in energy transduction.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciBABO262698:GJC2-3312-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar M-ring protein
Gene namesi
Name:fliF
Ordered Locus Names:BruAb2_1083
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000540 Componenti: Chromosome II

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921HelicalSequence analysisAdd
BLAST
Transmembranei445 – 46521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Bacterial flagellum, Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Flagellar M-ring proteinPRO_0000180875Add
BLAST

Interactioni

Subunit structurei

The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO52069.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FliF family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000265848.
KOiK02409.
OMAiQISMALA.
OrthoDBiEOG6KMB3J.

Family and domain databases

InterProiIPR013556. Flag_M-ring_C.
IPR000067. FlgMring_FliF.
IPR006182. YscJ_FliF.
[Graphical view]
PfamiPF01514. YscJ_FliF. 1 hit.
PF08345. YscJ_FliF_C. 1 hit.
[Graphical view]
PIRSFiPIRSF004862. FliF. 1 hit.
PRINTSiPR01009. FLGMRINGFLIF.
TIGRFAMsiTIGR00206. fliF. 1 hit.

Sequencei

Sequence statusi: Complete.

O52069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVWMQQNF QQLIEQLKGT LGKLGARKLI ALGLVGAALM GAILYTSIYL
60 70 80 90 100
GRPSYETLYV GLSRDDVNRM GLALGEAGIP FDVKSDGSSI LVPIGKAENA
110 120 130 140 150
RMYLAEKGLP TSNNAGYELF DNMGSLGLTS FMQEITRVRA LEGEIARTIQ
160 170 180 190 200
AIRGVKAARV HIVLAEKGSF RRGDQKPSAS VVIRAEGGFS AESAQSIRQL
210 220 230 240 250
VAAAVPSLDA SSVTVLDTNG HLLASAGEGA NGAALMTASL EQQVASHVDD
260 270 280 290 300
SIRKALAPYL GLGHFQTSVQ AALDTDRRQT KETTYDPESR VERSVRVVRE
310 320 330 340 350
SGDSRNNRND NATGVEQNIP QEQIQNRNGE SSTEKMDRRE ELTNYEVNSK
360 370 380 390 400
TVSTVSDGYS IKRLSIAVVI DQARLLQTAG TTPPPANFVD QQITKIRDLV
410 420 430 440 450
ATAAGLNTNR GDVINVTAVN FLDPAGADME PVSAPWTDTL LRQSGSYANA
460 470 480 490 500
LAILAAVGLL IWFGLRPLLR DQNVKPAGTE VAIREAGEVA TPNFIGGAES
510 520 530 540 550
VGEGVQAVIG GPAAYADQMK TSLSDLRQRM RMPAKLRLEQ MIEMDEERVA
560 570 580
AVLKQWIHET ASGREADPAK ASAMPELKAA
Length:580
Mass (Da):62,198
Last modified:June 21, 2005 - v3
Checksum:iAD6D676BEE3188D3
GO

Sequence cautioni

The sequence AAC01568.1 differs from that shown. Reason: Frameshift at position 522. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 861D → Y in AAC01568 (PubMed:11013709).Curated
Sequence conflicti336 – 3361M → T in AAC01568 (PubMed:11013709).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019251 Genomic DNA. Translation: AAC01568.1. Frameshift.
AE017224 Genomic DNA. Translation: AAX76456.1.
RefSeqiWP_011265437.1. NC_006933.1.

Genome annotation databases

EnsemblBacteriaiAAX76456; AAX76456; BruAb2_1083.
KEGGibmb:BruAb2_1083.
PATRICi17828515. VBIBruAbo15061_3417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019251 Genomic DNA. Translation: AAC01568.1. Frameshift.
AE017224 Genomic DNA. Translation: AAX76456.1.
RefSeqiWP_011265437.1. NC_006933.1.

3D structure databases

ProteinModelPortaliO52069.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX76456; AAX76456; BruAb2_1083.
KEGGibmb:BruAb2_1083.
PATRICi17828515. VBIBruAbo15061_3417.

Phylogenomic databases

HOGENOMiHOG000265848.
KOiK02409.
OMAiQISMALA.
OrthoDBiEOG6KMB3J.

Enzyme and pathway databases

BioCyciBABO262698:GJC2-3312-MONOMER.

Miscellaneous databases

PROiO52069.

Family and domain databases

InterProiIPR013556. Flag_M-ring_C.
IPR000067. FlgMring_FliF.
IPR006182. YscJ_FliF.
[Graphical view]
PfamiPF01514. YscJ_FliF. 1 hit.
PF08345. YscJ_FliF_C. 1 hit.
[Graphical view]
PIRSFiPIRSF004862. FliF. 1 hit.
PRINTSiPR01009. FLGMRINGFLIF.
TIGRFAMsiTIGR00206. fliF. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "On the presence and organization of open reading frames of the nonmotile pathogen Brucella abortus similar to class II, III, and IV flagellar genes and to LcrD virulence superfamily."
    Halling S.M.
    Microb. Comp. Genomics 3:21-29(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 544 / Biovar 1.
  2. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiFLIF_BRUAB
AccessioniPrimary (citable) accession number: O52069
Secondary accession number(s): Q576H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 21, 2005
Last modified: December 9, 2015
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Brucella species display species-specific inactivation of flagellar genes and are consequently nonmotile.Curated

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.