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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Mannheimia haemolytica (Pasteurella haemolytica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
OrganismiMannheimia haemolytica (Pasteurella haemolytica)
Taxonomic identifieri75985 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeMannheimia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631Chaperone protein DnaKPRO_0000078506Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei198 – 1981Phosphothreonine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO52064.

Expressioni

Inductioni

By stress conditions e.g. heat shock (By similarity).By similarity

Interactioni

Protein-protein interaction databases

STRINGi669262.COK_1441.

Structurei

3D structure databases

ProteinModelPortaliO52064.
SMRiO52064. Positions 1-603.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O52064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIIGIDLG TTNSCVAVMD GDKPRVIENA EGARTTPSII AYTDKETLVG
60 70 80 90 100
QPAKRQAITN PKNTLFAIKR LIGRRFTDAE VQRDIEIMPF EISKADNGDA
110 120 130 140 150
WVTVKGDKLA PPQISAEILK KMKKTAEDFL GEPVTEAVIT VPAYFNDAQR
160 170 180 190 200
QATKDAGRIA GLDVKRIINE PTAAALAYGL DSKKENQTIA VYDLGGGTFD
210 220 230 240 250
ISIIEIDNFD GEQTFEVRAT NGDTHLGGED FDNRVINYLV EEFKKQGVDL
260 270 280 290 300
RNDPMAMQRV KEAAEKAKIE LSSAQETEVN LPYITADATG PKHLNIKVTR
310 320 330 340 350
AKLESLVEDL VNRSLEPLKT ALADAGLSVG DINDVILVGG QTRMPLVQKK
360 370 380 390 400
VADFFGKTRK DVNPDEAVMA IGAAVQGGVL SGSVTDVLLL DVTPLSLGIE
410 420 430 440 450
TMGGVMTTLI EKNTTIPTKK SQVFSTAEDN QSAVTIHVLQ GERKRAADNK
460 470 480 490 500
SLGQFNLEGI NPAPRGMPQI EVTFDIDANG IINVSAKDKN TGKEQQIKIQ
510 520 530 540 550
ASSGLSDAEV EQMVRDAEAN AEADKKFEEL VQVCNQADGI AHATRKQITE
560 570 580 590 600
AGDALNADDK AKIEAAISEL ETAAKGEDKA EIEAKIEALI KASEPLMLAA
610 620 630
QAKAQGGEQP QQSQKDDGVV DAEFEEVKDN K
Length:631
Mass (Da):67,980
Last modified:June 1, 1998 - v1
Checksum:i4DE9FEC3A36B4E6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017730 Genomic DNA. Translation: AAB94554.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017730 Genomic DNA. Translation: AAB94554.1.

3D structure databases

ProteinModelPortaliO52064.
SMRiO52064. Positions 1-603.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi669262.COK_1441.

Proteomic databases

PRIDEiO52064.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAK_MANHA
AccessioniPrimary (citable) accession number: O52064
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: June 1, 1998
Last modified: November 11, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.