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O52058 (ACCC_ALLVD) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biotin carboxylase

EC=6.3.4.14
Alternative name(s):
Acetyl-CoA carboxylase subunit A
Short name=ACC
EC=6.4.1.2
Gene names
Name:accC
Ordered Locus Names:Alvin_1906
OrganismAllochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum) [Complete proteome] [HAMAP]
Taxonomic identifier572477 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeAllochromatium

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA By similarity.

Catalytic activity

ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Pathway

Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.

Subunit structure

Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex By similarity.

Sequence similarities

Contains 1 ATP-grasp domain.

Contains 1 biotin carboxylation domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Biotin carboxylase
PRO_0000146790

Regions

Domain4 – 448445Biotin carboxylation
Domain123 – 320198ATP-grasp

Sites

Active site2951 Potential

Experimental info

Sequence conflict4271I → L in AAB91545. Ref.2
Sequence conflict4371Missing in AAB91545. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O52058 [UniParc].

Last modified June 15, 2010. Version 2.
Checksum: 40510894E20C82E4

FASTA44949,268
        10         20         30         40         50         60 
MSAMIEKVLI ANRGEIALRI LRACRELGIK TVAVHSEADR DLKHVLLADE SVCIGPAPAM 

        70         80         90        100        110        120 
QSYLNVPAII SAAEVTDTVA IHPGYGFLSE NADFAERVEK SGFIFIGPRP ETIRLMGDKV 

       130        140        150        160        170        180 
SAIAAMKAAG VPCVPGSDGP IDDNKKRTLE LAREIGYPIM IKSSGGGGGR GMRVVHSEAT 

       190        200        210        220        230        240 
LLNAIALTRA EAAAAFNNDM VYMEKYLENP RHIEFQVLAD QMGNAIHLGE RDCSMQRRHQ 

       250        260        270        280        290        300 
KVVEEAPAPG ITEEQRREIG ERCAAACRSI GYRGAGTFEF LYENGQFYFI EMNTRVQVEH 

       310        320        330        340        350        360 
PVTEMVTGVD IVKEQILIAA GEPLRYRQSD IQMRGHAIEC RINAEHPETF MPSPGKITDF 

       370        380        390        400        410        420 
HAPGGPGVRI ETHIYSGYTV PCHYDSMIGK LITHGEDRES AVARMCNALR ETVIEGIHSN 

       430        440 
IKLQRSIMRD GAFLAGGANI HYLEKMLGL 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequence of chromosome of Allochromatium vinosum DSM 180."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Zigann R., Dahl C., Woyke T.
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17899 / DSM 180 / NBRC 103801 / D.
[2]"Molecular genetic evidence for extracytoplasmic localization of sulfur globules in Chromatium vinosum."
Pattaragulwanit K., Brune D.C., Trueper H.G., Dahl C.
Arch. Microbiol. 169:434-444(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 309-449.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001896 Genomic DNA. Translation: ADC62830.1.
AF017119 Genomic DNA. Translation: AAB91545.1.
RefSeqYP_003443862.1. NC_013851.1.

3D structure databases

ProteinModelPortalO52058.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADC62830; ADC62830; Alvin_1906.
GeneID8787270.
KEGGalv:Alvin_1906.
PATRIC31923588. VBIAllVin64954_1890.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000008988.
KOK01961.

Enzyme and pathway databases

BioCycAVIN572477:GCJK-1943-MONOMER.
UniPathwayUPA00655; UER00711.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProIPR004549. Acetyl_CoA_COase_biotin_COase.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF02785. Biotin_carb_C. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00514. accC. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACCC_ALLVD
AccessionPrimary (citable) accession number: O52058
Secondary accession number(s): D3RUH1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 15, 2010
Last modified: October 16, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways