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O52058

- ACCC_ALLVD

UniProt

O52058 - ACCC_ALLVD

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Protein

Biotin carboxylase

Gene

accC

Organism
Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.By similarity

Catalytic activityi

ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei295 – 2951Sequence Analysis

GO - Molecular functioni

  1. acetyl-CoA carboxylase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. biotin carboxylase activity Source: UniProtKB-EC
  4. metal ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
  2. malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

ATP-binding, Biotin, Nucleotide-binding

Enzyme and pathway databases

BioCyciAVIN572477:GCJK-1943-MONOMER.
RETL1328306-WGS:GSTH-4390-MONOMER.
UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin carboxylase (EC:6.3.4.14)
Alternative name(s):
Acetyl-CoA carboxylase subunit A (EC:6.4.1.2)
Short name:
ACC
Gene namesi
Name:accC
Ordered Locus Names:Alvin_1906
OrganismiAllochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum)
Taxonomic identifieri572477 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeAllochromatium
ProteomesiUP000001441: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Biotin carboxylasePRO_0000146790Add
BLAST

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliO52058.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 448445Biotin carboxylationAdd
BLAST
Domaini123 – 320198ATP-graspPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.PROSITE-ProRule annotation
Contains 1 biotin carboxylation domain.Curated

Phylogenomic databases

HOGENOMiHOG000008988.
KOiK01961.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR004549. Acetyl_CoA_COase_biotin_COase.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02785. Biotin_carb_C. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR00514. accC. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O52058-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAMIEKVLI ANRGEIALRI LRACRELGIK TVAVHSEADR DLKHVLLADE
60 70 80 90 100
SVCIGPAPAM QSYLNVPAII SAAEVTDTVA IHPGYGFLSE NADFAERVEK
110 120 130 140 150
SGFIFIGPRP ETIRLMGDKV SAIAAMKAAG VPCVPGSDGP IDDNKKRTLE
160 170 180 190 200
LAREIGYPIM IKSSGGGGGR GMRVVHSEAT LLNAIALTRA EAAAAFNNDM
210 220 230 240 250
VYMEKYLENP RHIEFQVLAD QMGNAIHLGE RDCSMQRRHQ KVVEEAPAPG
260 270 280 290 300
ITEEQRREIG ERCAAACRSI GYRGAGTFEF LYENGQFYFI EMNTRVQVEH
310 320 330 340 350
PVTEMVTGVD IVKEQILIAA GEPLRYRQSD IQMRGHAIEC RINAEHPETF
360 370 380 390 400
MPSPGKITDF HAPGGPGVRI ETHIYSGYTV PCHYDSMIGK LITHGEDRES
410 420 430 440
AVARMCNALR ETVIEGIHSN IKLQRSIMRD GAFLAGGANI HYLEKMLGL
Length:449
Mass (Da):49,268
Last modified:June 15, 2010 - v2
Checksum:i40510894E20C82E4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti427 – 4271I → L in AAB91545. (PubMed:9560425)Curated
Sequence conflicti437 – 4371Missing in AAB91545. (PubMed:9560425)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001896 Genomic DNA. Translation: ADC62830.1.
AF017119 Genomic DNA. Translation: AAB91545.1.
RefSeqiYP_003443862.1. NC_013851.1.

Genome annotation databases

EnsemblBacteriaiADC62830; ADC62830; Alvin_1906.
GeneIDi8787270.
KEGGialv:Alvin_1906.
PATRICi31923588. VBIAllVin64954_1890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001896 Genomic DNA. Translation: ADC62830.1 .
AF017119 Genomic DNA. Translation: AAB91545.1 .
RefSeqi YP_003443862.1. NC_013851.1.

3D structure databases

ProteinModelPortali O52058.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADC62830 ; ADC62830 ; Alvin_1906 .
GeneIDi 8787270.
KEGGi alv:Alvin_1906.
PATRICi 31923588. VBIAllVin64954_1890.

Phylogenomic databases

HOGENOMi HOG000008988.
KOi K01961.

Enzyme and pathway databases

UniPathwayi UPA00655 ; UER00711 .
BioCyci AVIN572477:GCJK-1943-MONOMER.
RETL1328306-WGS:GSTH-4390-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR004549. Acetyl_CoA_COase_biotin_COase.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02785. Biotin_carb_C. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view ]
SMARTi SM00878. Biotin_carb_C. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR00514. accC. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of chromosome of Allochromatium vinosum DSM 180."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Zigann R., Dahl C., Woyke T.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17899 / DSM 180 / NBRC 103801 / D.
  2. "Molecular genetic evidence for extracytoplasmic localization of sulfur globules in Chromatium vinosum."
    Pattaragulwanit K., Brune D.C., Trueper H.G., Dahl C.
    Arch. Microbiol. 169:434-444(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 309-449.

Entry informationi

Entry nameiACCC_ALLVD
AccessioniPrimary (citable) accession number: O52058
Secondary accession number(s): D3RUH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 15, 2010
Last modified: October 1, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3