SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O52058

- ACCC_ALLVD

UniProt

O52058 - ACCC_ALLVD

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Biotin carboxylase
Gene
accC, Alvin_1906
Organism
Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA By similarity.

Catalytic activityi

ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei295 – 2951 Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acetyl-CoA carboxylase activity Source: UniProtKB-EC
  3. biotin carboxylase activity Source: UniProtKB-EC
  4. metal ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
  2. malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

ATP-binding, Biotin, Nucleotide-binding

Enzyme and pathway databases

BioCyciAVIN572477:GCJK-1943-MONOMER.
RETL1328306-WGS:GSTH-4390-MONOMER.
UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin carboxylase (EC:6.3.4.14)
Alternative name(s):
Acetyl-CoA carboxylase subunit A (EC:6.4.1.2)
Short name:
ACC
Gene namesi
Name:accC
Ordered Locus Names:Alvin_1906
OrganismiAllochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum)
Taxonomic identifieri572477 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeAllochromatium
ProteomesiUP000001441: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Biotin carboxylase
PRO_0000146790Add
BLAST

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex By similarity.

Structurei

3D structure databases

ProteinModelPortaliO52058.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 448445Biotin carboxylation
Add
BLAST
Domaini123 – 320198ATP-grasp
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.

Phylogenomic databases

HOGENOMiHOG000008988.
KOiK01961.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR004549. Acetyl_CoA_COase_biotin_COase.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02785. Biotin_carb_C. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR00514. accC. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O52058-1 [UniParc]FASTAAdd to Basket

« Hide

MSAMIEKVLI ANRGEIALRI LRACRELGIK TVAVHSEADR DLKHVLLADE    50
SVCIGPAPAM QSYLNVPAII SAAEVTDTVA IHPGYGFLSE NADFAERVEK 100
SGFIFIGPRP ETIRLMGDKV SAIAAMKAAG VPCVPGSDGP IDDNKKRTLE 150
LAREIGYPIM IKSSGGGGGR GMRVVHSEAT LLNAIALTRA EAAAAFNNDM 200
VYMEKYLENP RHIEFQVLAD QMGNAIHLGE RDCSMQRRHQ KVVEEAPAPG 250
ITEEQRREIG ERCAAACRSI GYRGAGTFEF LYENGQFYFI EMNTRVQVEH 300
PVTEMVTGVD IVKEQILIAA GEPLRYRQSD IQMRGHAIEC RINAEHPETF 350
MPSPGKITDF HAPGGPGVRI ETHIYSGYTV PCHYDSMIGK LITHGEDRES 400
AVARMCNALR ETVIEGIHSN IKLQRSIMRD GAFLAGGANI HYLEKMLGL 449
Length:449
Mass (Da):49,268
Last modified:June 15, 2010 - v2
Checksum:i40510894E20C82E4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti427 – 4271I → L in AAB91545. 1 Publication
Sequence conflicti437 – 4371Missing in AAB91545. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001896 Genomic DNA. Translation: ADC62830.1.
AF017119 Genomic DNA. Translation: AAB91545.1.
RefSeqiYP_003443862.1. NC_013851.1.

Genome annotation databases

EnsemblBacteriaiADC62830; ADC62830; Alvin_1906.
GeneIDi8787270.
KEGGialv:Alvin_1906.
PATRICi31923588. VBIAllVin64954_1890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001896 Genomic DNA. Translation: ADC62830.1 .
AF017119 Genomic DNA. Translation: AAB91545.1 .
RefSeqi YP_003443862.1. NC_013851.1.

3D structure databases

ProteinModelPortali O52058.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADC62830 ; ADC62830 ; Alvin_1906 .
GeneIDi 8787270.
KEGGi alv:Alvin_1906.
PATRICi 31923588. VBIAllVin64954_1890.

Phylogenomic databases

HOGENOMi HOG000008988.
KOi K01961.

Enzyme and pathway databases

UniPathwayi UPA00655 ; UER00711 .
BioCyci AVIN572477:GCJK-1943-MONOMER.
RETL1328306-WGS:GSTH-4390-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR004549. Acetyl_CoA_COase_biotin_COase.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02785. Biotin_carb_C. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view ]
SMARTi SM00878. Biotin_carb_C. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR00514. accC. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of chromosome of Allochromatium vinosum DSM 180."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Zigann R., Dahl C., Woyke T.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17899 / DSM 180 / NBRC 103801 / D.
  2. "Molecular genetic evidence for extracytoplasmic localization of sulfur globules in Chromatium vinosum."
    Pattaragulwanit K., Brune D.C., Trueper H.G., Dahl C.
    Arch. Microbiol. 169:434-444(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 309-449.

Entry informationi

Entry nameiACCC_ALLVD
AccessioniPrimary (citable) accession number: O52058
Secondary accession number(s): D3RUH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 15, 2010
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi