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Protein

Putative arsenical resistance operon repressor ArsR

Gene

arsR

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor for the arsADRC operon.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi73 – 9624H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Arsenical resistance, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative arsenical resistance operon repressor ArsR
Gene namesi
Name:arsR
Ordered Locus Names:VNG_5182G
Encoded oniPlasmid pNRC1000 Publication
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Plasmid pNRC100

Pathology & Biotechi

Disruption phenotypei

Deletion of the arsADRC operon results in increased sensitivity to arsenite and antimonite but not arsenate.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 129129Putative arsenical resistance operon repressor ArsRPRO_0000429114Add
BLAST

Expressioni

Inductioni

By arsenite and antimonite.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO52029.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 12993HTH arsR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH arsR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiO52029.
OMAiCACEIER.
PhylomeDBiO52029.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O52029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTERLQRY LTDERGGCGD EEVAQRLDEL EELDAAAGGP ALEADVGVLS
60 70 80 90 100
ALANETRYKI IRILHIAGEE LCVCEFSPLL DVSDSAISHS LSQLTEAGLV
110 120
TRRKDGKWRK YQTTMRGDAL LVALNGSRR
Length:129
Mass (Da):14,150
Last modified:June 1, 1998 - v1
Checksum:iD64406438B042E2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016485 Genomic DNA. Translation: AAC82909.1.
PIRiT08342.

Genome annotation databases

EnsemblBacteriaiAAC82909; AAC82909; AAC82909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016485 Genomic DNA. Translation: AAC82909.1.
PIRiT08342.

3D structure databases

ProteinModelPortaliO52029.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC82909; AAC82909; AAC82909.

Phylogenomic databases

InParanoidiO52029.
OMAiCACEIER.
PhylomeDBiO52029.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Snapshot of a large dynamic replicon in a halophilic archaeon: megaplasmid or minichromosome?"
    Ng W.V., Ciufo S.A., Smith T.M., Bumgarner R.E., Baskin D., Faust J., Hall B., Loretz C., Seto J., Slagel J., Hood L., DasSarma S.
    Genome Res. 8:1131-1141(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.
  3. "Arsenic resistance in Halobacterium sp. strain NRC-1 examined by using an improved gene knockout system."
    Wang G., Kennedy S.P., Fasiludeen S., Rensing C., DasSarma S.
    J. Bacteriol. 186:3187-3194(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, DISRUPTION PHENOTYPE.
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiARSR_HALSA
AccessioniPrimary (citable) accession number: O52029
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 14, 2014
Last sequence update: June 1, 1998
Last modified: December 9, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.