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Protein

Ornithine carbamoyltransferase, catabolic

Gene

arcB

Organism
Borreliella afzelii (Borrelia afzelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Pathwayi: L-arginine degradation via ADI pathway

This protein is involved in step 2 of the subpathway that synthesizes carbamoyl phosphate from L-arginine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Arginine deiminase (arcA)
  2. Ornithine carbamoyltransferase, catabolic (arcB)
This subpathway is part of the pathway L-arginine degradation via ADI pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes carbamoyl phosphate from L-arginine, the pathway L-arginine degradation via ADI pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Carbamoyl phosphateBy similarity
Binding sitei72 – 721Carbamoyl phosphateBy similarity
Binding sitei83 – 831Carbamoyl phosphateBy similarity
Binding sitei107 – 1071Carbamoyl phosphateBy similarity
Binding sitei166 – 1661OrnithineBy similarity
Binding sitei230 – 2301OrnithineBy similarity
Binding sitei297 – 2971Carbamoyl phosphateBy similarity
Binding sitei315 – 3151Carbamoyl phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Arginine metabolism

Enzyme and pathway databases

UniPathwayiUPA00254; UER00365.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase, catabolic (EC:2.1.3.3)
Short name:
OTCase
Gene namesi
Name:arcB
OrganismiBorreliella afzelii (Borrelia afzelii)
Taxonomic identifieri29518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Ornithine carbamoyltransferase, catabolicPRO_0000112888Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi390236.BAPKO_0897.

Structurei

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei31 – 311Important for structural integrityBy similarity
Sitei147 – 1471Important for structural integrityBy similarity

3D structure databases

ProteinModelPortaliO51897.
SMRiO51897. Positions 2-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni56 – 605Carbamoyl phosphate bindingBy similarity
Regioni134 – 1374Carbamoyl phosphate bindingBy similarity
Regioni234 – 2352Ornithine bindingBy similarity
Regioni269 – 2724Carbamoyl phosphate bindingBy similarity

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

eggNOGiENOG4105DBV. Bacteria.
COG0078. LUCA.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. OTCase_ArgI.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNLRNRSFL NLLDFTSKDI KYLLDLSIDL KKSKYAGIEV QKLKGKNIVI
60 70 80 90 100
IFEKDSTRTR CAFEIAAYDQ GANITYLGPK GNQIGVKESM KDTARVLGRM
110 120 130 140 150
YDAIGFRGFS QETVECLANY SNVPVYNGLT DISHPTQILA DLMTIKEHKG
160 170 180 190 200
SLKGIKIVFC GDGRGNIANS LLKGCAIMGL DFRIFAPKEL FPDSNLTLKA
210 220 230 240 250
KSLALKSGGK ITITDSKEEA VKCADVVYTD VWVSMGEESN WEDRINLLKL
260 270 280 290 300
YQVNKELMCM AKDDAIFMHC LPAFHDLSTV VGRDIFDKYG LDGIEVTEEI
310 320
FESKNSVVFD VAENRVHAIK AVMVSTLG
Length:328
Mass (Da):36,561
Last modified:June 1, 1998 - v1
Checksum:iEC7F89DFCD3547AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008219 Genomic DNA. Translation: AAB93999.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008219 Genomic DNA. Translation: AAB93999.1.

3D structure databases

ProteinModelPortaliO51897.
SMRiO51897. Positions 2-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi390236.BAPKO_0897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105DBV. Bacteria.
COG0078. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00254; UER00365.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. OTCase_ArgI.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOTCC_BORAF
AccessioniPrimary (citable) accession number: O51897
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 1998
Last modified: February 17, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.