O51897 (OTCC_BORAF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3

Gene names

Name:

arcB

Organism

Borrelia afzelii

Taxonomic identifier

29518 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 328	328	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000112888
Regions
	Region	56 – 60	5	Carbamoyl phosphate binding By similarity
	Region	269 – 272	4	Ornithine binding By similarity
Sites
	Binding site	107	1	Carbamoyl phosphate By similarity
	Binding site	134	1	Carbamoyl phosphate By similarity
	Site	31	1	Important for structural integrity By similarity
	Site	147	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	O51897 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: EC7F89DFCD3547AD	FASTA	328	36,561
	10 20 30 40 50 60 MYNLRNRSFL NLLDFTSKDI KYLLDLSIDL KKSKYAGIEV QKLKGKNIVI IFEKDSTRTR 70 80 90 100 110 120 CAFEIAAYDQ GANITYLGPK GNQIGVKESM KDTARVLGRM YDAIGFRGFS QETVECLANY 130 140 150 160 170 180 SNVPVYNGLT DISHPTQILA DLMTIKEHKG SLKGIKIVFC GDGRGNIANS LLKGCAIMGL 190 200 210 220 230 240 DFRIFAPKEL FPDSNLTLKA KSLALKSGGK ITITDSKEEA VKCADVVYTD VWVSMGEESN 250 260 270 280 290 300 WEDRINLLKL YQVNKELMCM AKDDAIFMHC LPAFHDLSTV VGRDIFDKYG LDGIEVTEEI 310 320 FESKNSVVFD VAENRVHAIK AVMVSTLG

References

[1]	"Telomeres of the linear chromosomes of Lyme disease spirochaetes: nucleotide sequence and possible exchange with linear plasmid telomeres." Casjens S., Murphy M., DeLange M., Sampson L., van Vugt R., Huang W.M. Mol. Microbiol. 26:581-596(1997) [PubMed: 9402027] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: R-IP3.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF008219 Genomic DNA. Translation: AAB93999.1.
3D structure databases
ProteinModelPortal	O51897.
SMR	O51897. Positions 2-328.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
PhylomeDB	O51897.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_BORAF

Accession

Primary (citable) accession number: O51897

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program