O51896 (ARCA_BORAF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine deiminase
Short name=ADI
EC=3.5.3.6

Alternative name(s):
Arginine dihydrolase
Short name=AD

Gene names

Name:

arcA

Organism

Borrelia afzelii

Taxonomic identifier

29518 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-arginine + H2O = L-citrulline + NH3. HAMAP-Rule MF_00242
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 1/2. HAMAP-Rule MF_00242
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00242.
Sequence similarities	Belongs to the arginine deiminase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Hydrolase
Gene Ontology (GO)
Biological_process	arginine catabolic process to ornithine Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	arginine deiminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 409	409	Arginine deiminase HAMAP-Rule MF_00242		PRO_0000182202
Sites
	Active site	399	1	Amidino-cysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O51896 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 0524047ECA16649C	FASTA	409	46,812
	10 20 30 40 50 60 MEEYLNPINI FSEIGRLKKV LLHRPGEELE NLTPFIMKNF LFDDIPYLEV ARQEHEVFAS 70 80 90 100 110 120 ILKNNLVEIE YIEDLISEVL VSSVALENKF ISQFILEAEI KTDFTINLLK DYFSSLTIDN 130 140 150 160 170 180 MISKMISGVV TEELKNYTSS LDDLVNGANL FIIDPMPNVL FTRDPFASIG NGVTINKMFT 190 200 210 220 230 240 KVRQRETIFA EYIFKYHPVY KENVPIWLNR WEEASLEGGD ELVLNKGLLV IGISERTEAK 250 260 270 280 290 300 SVEKLAISLF KNKTSFDTIL AFQIPKNRSY MHLDTVFTQI DYSVFTSFTS DDMYFSIYVL 310 320 330 340 350 360 TYNPSSSKIH IKKEKARIKD VLSFYLGRKI DIIKCAGGDL IHGAREQWND GANVLAIAPG 370 380 390 400 EIIAYSRNHV TNKLFEENGI KVHRIPSSEL SRGRGGPRCM SMPLIREDI

References

[1]

"Telomeres of the linear chromosomes of Lyme disease spirochaetes: nucleotide sequence and possible exchange with linear plasmid telomeres." Casjens S., Murphy M., DeLange M., Sampson L., van Vugt R., Huang W.M. Mol. Microbiol. 26:581-596(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: R-IP3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF008219 Genomic DNA. Translation: AAB93998.1.
3D structure databases
ProteinModelPortal	O51896.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00254; UER00364.
Family and domain databases
HAMAP	MF_00242. Arg_deiminase.
InterPro	IPR003198. Amidino_trans. IPR003876. Arg_deiminase. [Graphical view]
PANTHER	PTHR12737:SF9. PTHR12737:SF9. 1 hit.
Pfam	PF02274. Amidinotransf. 1 hit. [Graphical view]
PIRSF	PIRSF006356. Arg_deiminase. 1 hit.
PRINTS	PR01466. ARGDEIMINASE.
TIGRFAMs	TIGR01078. arcA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARCA_BORAF

Accession

Primary (citable) accession number: O51896

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 1, 1998
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program