O51890 (THIO_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thioredoxin
Short name=Trx

Gene names

Name:	trxA
Ordered Locus Names:	BUsg_573

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Schizaphis graminum)

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Sequence similarities	Belongs to the thioredoxin family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Domain	Redox-active center
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW glycerol ether metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 108	108	Thioredoxin		PRO_0000120079
Regions
	Domain	2 – 108	107	Thioredoxin
Amino acid modifications
	Disulfide bond	32 ↔ 35		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	O51890 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: F3204CE0A323E9AE	FASTA	108	12,440
	10 20 30 40 50 60 MNKIIELTDQ NFEKEVLEHK SFVLVDFWAE WCNPCKILAP ILEEIAQEYF NKIKVGKLNI 70 80 90 100 EKNPNTAPIY SIRGIPALLL FHGREVLATK VGAISKLQLK DFLDENIK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of a 34.7-kb DNA segment from the genome of Buchnera aphidicola (endosymbiont of aphids) containing groEL, dnaA, the atp operon, gidA, and rho." Clark M.A., Baumann L., Baumann P. Curr. Microbiol. 36:158-163(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF008210 Genomic DNA. Translation: AAC38128.1. AE013218 Genomic DNA. Translation: AAM68107.1.
RefSeq	NP_660896.1. NC_004061.1.
3D structure databases
ProteinModelPortal	O51890.
SMR	O51890. Positions 2-107.
ModBase	Search...
Protein-protein interaction databases
STRING	198804.BUsg573.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM68107; AAM68107; BUsg_573.
GeneID	1005580.
KEGG	bas:BUsg573.
PATRIC	21248042. VBIBucAph100086_0609.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0526.
KO	K03671.
OMA	YEVSSIP.
ProtClustDB	CLSK873791.
Enzyme and pathway databases
BioCyc	BAPH198804:GHMG-609-MONOMER.
Family and domain databases
Gene3D	3.40.30.10. 1 hit.
InterPro	IPR005746. Thioredoxin. IPR012336. Thioredoxin-like_fold. IPR013766. Thioredoxin_domain. [Graphical view]
PANTHER	PTHR10438. PTHR10438. 1 hit.
Pfam	PF00085. Thioredoxin. 1 hit. [Graphical view]
PIRSF	PIRSF000077. Thioredoxin. 1 hit.
PRINTS	PR00421. THIOREDOXIN.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR01068. thioredoxin. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. False negative. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THIO_BUCAP

Accession

Primary (citable) accession number: O51890

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program