Reviewed, UniProtKB/Swiss-Prot O51878 (ATP6_BUCAP)

Names and origin

Protein names

Recommended name:
    ATP synthase subunit a
Alternative name(s):
    F-ATPase subunit 6
    ATP synthase F0 sector subunit a

Gene names

Name:	atpB
Ordered Locus Names:	BUsg_002

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane By similarity.
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ATPase A chain family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(0) Cell membrane Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	plasma membrane ATP synthesis coupled proton transport Inferred from electronic annotation. Source: HAMAP
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	hydrogen ion transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	ATP synthase subunit a HAMAP MF_01393		PRO_0000082050
Regions
	Transmembrane	41 – 61	21	Potential
	Transmembrane	110 – 130	21	Potential
	Transmembrane	143 – 165	23	Potential
	Transmembrane	188 – 208	21	Potential
	Transmembrane	222 – 242	21	Potential
	Transmembrane	243 – 263	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	O51878-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: DCD8C7D2C98C37CC	FASTA	272	31,254
	10 20 30 40 50 60 MSLEKISNPQ KYISHHLNHL QIDLCNFKFV EPGKIVSHFW VLNIDSIIFS LVLGCFFLSI 70 80 90 100 110 120 FYTVAKKITT GVPNGLQASI ELIFDFIRSN VKSMYQGKNP LIAPLSLTVF VWVFLMNLMD 130 140 150 160 170 180 LIPIDFFPFI SERFFHFPAM RIVPSADINI TLSMSLGVFI LILFYSVKMK GLIGFCKELT 190 200 210 220 230 240 LQPFNHPVFF IFNFLLELVS LLSKPISLGL RLFGNMYSGE MIFILIAGLL PWWSQFFLNV 250 260 270 PWAIFHILII SLQAFIFMVL TIVYLSMASQ SH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The (F1F0) ATP synthase of Buchnera aphidicola (endosymbiont of aphids): genetic analysis of the putative ATP operon." Clark M.A., Baumann P. Curr. Microbiol. 35:84-89(1997) [PubMed: 9216881] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of a 34.7-kb DNA segment from the genome of Buchnera aphidicola (endosymbiont of aphids) containing groEL, dnaA, the atp operon, gidA, and rho." Clark M.A., Baumann L., Baumann P. Curr. Microbiol. 36:158-163(1998) [PubMed: 9516544] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF008210 Genomic DNA. Translation: AAC38116.1. AE013218 Genomic DNA. Translation: AAM67574.1.
RefSeq	NP_660363.1.
3D structure databases
SMR	O51878. Positions 96-266.
ModBase	Search...
Genome annotation databases
GeneID	1005812.
GenomeReviews	Gene locus BUsg_002 in contig AE013218_GR.
KEGG	bas:BUsg002.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG734175.
OMA	LPWWSQF.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG002-MON.
Family and domain databases
HAMAP	MF_01393. [Tree]
InterPro	IPR000568. ATPase_F0-cplx_asu. [Graphical view]
Gene3D	G3DSA:1.20.120.220. ATPase_F0_A. 1 hit.
PANTHER	PTHR11410. ATPase_F0_A. 1 hit.
Pfam	PF00119. ATP-synt_A. 1 hit. [Graphical view]
PRINTS	PR00123. ATPASEA.
PROSITE	PS00449. ATPASE_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATP6_BUCAP

Accession

Primary (citable) accession number: O51878

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	December 15, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)