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O51874 (ATPA_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP synthase subunit alpha
EC=3.6.3.14
Alternative name(s):
ATP synthase F1 sector subunit alpha
F-ATPase subunit alpha
Gene names
Name:atpA
Ordered Locus Names:BUsg_006
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length510 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. HAMAP MF_01346

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_01346

Subunit structure

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein By similarity HAMAP MF_01346.

Sequence similarities

Belongs to the ATPase alpha/beta chains family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 510510ATP synthase subunit alpha HAMAP MF_01346
PRO_0000144321

Regions

Nucleotide binding169 – 1768ATP Potential

Sites

Site3731Required for activity

Experimental info

Sequence conflict2691A → R no nucleotide entry Ref.1
Sequence conflict2691A → R in AAC38112. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O51874 [UniParc].

Last modified August 30, 2002. Version 2.
Checksum: EE2884411AFB5E3A

FASTA51056,391
        10         20         30         40         50         60 
MQLNSTEISQ LIKERIAQFE VFNQSYNEGT IISVNDGIIK IYGLSDVMLG EMILLPDNEY 

        70         80         90        100        110        120 
AIALNIERDT IGAVVMGPYI HITEGTKVRC TGKILEVPVG VALLGRIVNA LGFPIDGKGS 

       130        140        150        160        170        180 
IEHDIYLPVE ADAPGVIERE SINEPIQTGY KAIDAMVPIG RGQRELIIGD RQTGKTALAI 

       190        200        210        220        230        240 
DTIINQKKIN LPCVYVAIGQ KLSTIINVVK KLDEHDALLN TIVVVASASE AASLQYLAPY 

       250        260        270        280        290        300 
SGCAMGEYFR DRGKDALIVY DDLSKHAVAY RQISLLLRRP PGREAFPGDV FYLHSRLLER 

       310        320        330        340        350        360 
ASRVSKEHVK NVTKGKITGK TGSLTALPII ETQSGDVSAF VPTNVISITD GQIFLESNLF 

       370        380        390        400        410        420 
NSGIRPAVNA GISVSRVGSA AQTKIIKKLS SGIRTALAQY HELAAFSQFA SDLDQTTRKQ 

       430        440        450        460        470        480 
LIYGQKITEL LKQKQYRPMS ISEQGLMFFI AENNFLDDIS VENIIQFEKE ILTYAYNYHL 

       490        500        510 
DLMEEINKDG NFNDIIKKKF IELINNFKNS

« Hide

References

« Hide 'large scale' references
[1]"The (F1F0) ATP synthase of Buchnera aphidicola (endosymbiont of aphids): genetic analysis of the putative ATP operon."
Clark M.A., Baumann P.
Curr. Microbiol. 35:84-89(1997) [PubMed: 9216881] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis of a 34.7-kb DNA segment from the genome of Buchnera aphidicola (endosymbiont of aphids) containing groEL, dnaA, the atp operon, gidA, and rho."
Clark M.A., Baumann L., Baumann P.
Curr. Microbiol. 36:158-163(1998) [PubMed: 9516544] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF008210 Genomic DNA. Translation: AAC38112.1.
AE013218 Genomic DNA. Translation: AAM67578.1.
RefSeqNP_660367.1. NC_004061.1.

3D structure databases

ProteinModelPortalO51874.
SMRO51874. Positions 27-509.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000000455; EBBUCP00000000455; EBBUCG00000000455.
GeneID1005804.
GenomeReviewsGene locus BUsg_006 in contig AE013218_GR.
KEGGbas:BUsg006.
PATRIC21246767. VBIBucAph100086_0006.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000007862.
HOGENOMHBG565875.
OMAQKRWNNG.
ProtClustDBPRK09281.

Enzyme and pathway databases

BioCycBAPH198804:BUSG006-MONOMER.

Family and domain databases

HAMAPMF_01346. ATP_synth_alpha_bact.
[Tree]
InterProIPR020003. ATPase_a/bsu_AS.
IPR005294. ATPase_F1-cplx_asu.
IPR018118. ATPase_F1/A1-cplx_a/bsu_N.
IPR023366. ATPase_F1/A1-cplx_a_su_N.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR004100. ATPase_F1/V1/A1-cplx_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
[Graphical view]
Gene3DG3DSA:2.40.30.20. G3DSA:2.40.30.20. 1 hit.
KOK02111.
PANTHERPTHR15184:SF3. ATPase_F1_a. 1 hit.
PfamPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMSSF47917. ATPase_a/b_C. 1 hit.
SSF50615. ATPase_a/b_N. 1 hit.
TIGRFAMsTIGR00962. AtpA. 1 hit.
PROSITEPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATPA_BUCAP
AccessionPrimary (citable) accession number: O51874
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 30, 2002
Last modified: January 25, 2012
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents