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Protein

60 kDa chaperonin

Gene

groL

Organism
Buchnera aphidicola subsp. Myzus persicae (Myzus persicae primary endosymbiont)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Symbionin
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA, symL
OrganismiBuchnera aphidicola subsp. Myzus persicae (Myzus persicae primary endosymbiont)
Taxonomic identifieri98795 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 54854860 kDa chaperoninPRO_0000063309Add
BLAST

Proteomic databases

PRIDEiO51832.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO51832.
SMRiO51832. Positions 2-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51832-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKDVKFGN EARIKMLRGV NVLADAVKVT LGPKGRNVVL DKSFGAPSIT
60 70 80 90 100
KDGVSVAREI ELEDKFENMG AQMVKEVASK ANDAAGDGTT TATLLAQSIV
110 120 130 140 150
NEGLKAVAAG MNPMDLKRGI DKAVISAVEE LKNLSVPCSD SKAITQVGTI
160 170 180 190 200
SANADEKVGA LIAEAMEKVG NDGVITVEEG TGLQNELEVV KGMQFDRGYL
210 220 230 240 250
SPYFINKPET GIVELENPYI LVADKKISNV REMLPILESV AKSGKPLLII
260 270 280 290 300
SEDLEGEALA TLVVNSMRGI VKVAAVKAPG FGDRRKAMLQ DISILTGGSV
310 320 330 340 350
ISEELAMELE KSTLEDLGQA KRVVISKDTT TIIGGVGEKH TIQSRISQIR
360 370 380 390 400
QEIQEATSDY DKEKLNERLA KLSGGVAVLK VGAATEVEMK EKKARVEDAL
410 420 430 440 450
HATRAAVEEG VVAGGGVALV RVAGKTSNLR GQNEDQNVGI RVALRAMEAP
460 470 480 490 500
LRQIVSNSGE EPSVVTNNVK DGKGNYGYNA ATDEYGDMID FGILDPTKVT
510 520 530 540
RSALQYAASV AGLMITTECM VTDLPKEDKS SDSNSSPAGG MGGMGGMM
Length:548
Mass (Da):57,883
Last modified:June 1, 1998 - v1
Checksum:iAD61917965E4184A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1111M → K in AAK52957 (Ref. 2) Curated
Sequence conflicti222 – 2221V → M in AAK52957 (Ref. 2) Curated
Sequence conflicti348 – 3481Q → H in AAK52957 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003957 Genomic DNA. Translation: AAC04237.1.
AF367248 Genomic DNA. Translation: AAK52957.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003957 Genomic DNA. Translation: AAC04237.1.
AF367248 Genomic DNA. Translation: AAK52957.1.

3D structure databases

ProteinModelPortaliO51832.
SMRiO51832. Positions 2-526.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO51832.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Potato leafroll virus binds to the equatorial domain of the aphid endosymbiotic GroEL homolog."
    Hogenhout S.A., van der Wilk F., Verbeek M., Goldbach R.W., van den Heuvel J.F.J.M.
    J. Virol. 72:358-365(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cui X., Wu Y., Lin L.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCH60_BUCMP
AccessioniPrimary (citable) accession number: O51832
Secondary accession number(s): Q93T48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 11, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.