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Protein

Probable 4-methylmuconolactone transporter

Gene

mmlH

Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Probable uptake of 4-methylmuconolactone.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.1.15.9. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 4-methylmuconolactone transporter
Gene namesi
Name:mmlH
Ordered Locus Names:Reut_A1504
OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002697 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 50PeriplasmicSequence analysis3
Transmembranei51 – 71Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini72 – 80CytoplasmicSequence analysis9
Transmembranei81 – 101Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini102 – 110PeriplasmicSequence analysis9
Transmembranei111 – 131Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini132 – 145CytoplasmicSequence analysisAdd BLAST14
Transmembranei146 – 166Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini167PeriplasmicSequence analysis1
Transmembranei168 – 188Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini189 – 227CytoplasmicSequence analysisAdd BLAST39
Transmembranei228 – 248Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini249 – 252PeriplasmicSequence analysis4
Transmembranei253 – 273Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini274 – 287CytoplasmicSequence analysisAdd BLAST14
Transmembranei288 – 308Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini309 – 314PeriplasmicSequence analysis6
Transmembranei315 – 335Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini336 – 356CytoplasmicSequence analysisAdd BLAST21
Transmembranei357 – 371Helical; Name=11Sequence analysisAdd BLAST15
Topological domaini372 – 377PeriplasmicSequence analysis6
Transmembranei378 – 398Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini399 – 428CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503091 – 428Probable 4-methylmuconolactone transporterAdd BLAST428

Interactioni

Protein-protein interaction databases

STRINGi264198.Reut_A1504.

Structurei

3D structure databases

ProteinModelPortaliO51798.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107RGD. Bacteria.
ENOG410ZVI6. LUCA.
HOGENOMiHOG000136135.
OMAiCYAILVW.
OrthoDBiPOG091H0B4X.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAWYKAGSP QQKKTFWACY SGWALDSFDM QMFSFLLPAL TLTWGLTKAE
60 70 80 90 100
VGVLGTVALV VTAIGGWGAG ILSDRYGRAR ILVLAIIWFT LFGVLAGFAQ
110 120 130 140 150
SYQQLLIART LQGLGFGGEW AVGAALMAEV IDSRHRGKAI GFVQSGFALG
160 170 180 190 200
WALAVVVATL LLAWLPKEMA WRVAFWSGII PALIVLFIRR HVKDSSMFER
210 220 230 240 250
ARQSRAPRAS LSSVFNRKYA RTLALSSVLV IGLQAGCYAI LVWLPSLLNQ
260 270 280 290 300
RQVAAGSMIV TVFIMAFGSF CGFAVTADLS DRIGRRPTLI LLSVCAWIVT
310 320 330 340 350
VSYMLLPLNT TLTAILGFLV GFSAIGMFAA LGPFLSELFP TNVRTTCMGF
360 370 380 390 400
AYNVGKSIGA GSVVGVGVLS THIGLANAMG TFCLVAYAFA VFGIMLLPET
410 420
RGIAIENIGE ADAHSPAAPL AQPASARS
Length:428
Mass (Da):45,804
Last modified:June 1, 1998 - v1
Checksum:i7CC9096F6F7BE230
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99639 Genomic DNA. Translation: CAA67957.1.
CP000090 Genomic DNA. Translation: AAZ60871.1.
RefSeqiWP_011297670.1. NC_007347.1.

Genome annotation databases

EnsemblBacteriaiAAZ60871; AAZ60871; Reut_A1504.
KEGGireu:Reut_A1504.
PATRICi20228527. VBIRalEut24049_2126.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99639 Genomic DNA. Translation: CAA67957.1.
CP000090 Genomic DNA. Translation: AAZ60871.1.
RefSeqiWP_011297670.1. NC_007347.1.

3D structure databases

ProteinModelPortaliO51798.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264198.Reut_A1504.

Protein family/group databases

TCDBi2.A.1.15.9. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ60871; AAZ60871; Reut_A1504.
KEGGireu:Reut_A1504.
PATRICi20228527. VBIRalEut24049_2126.

Phylogenomic databases

eggNOGiENOG4107RGD. Bacteria.
ENOG410ZVI6. LUCA.
HOGENOMiHOG000136135.
OMAiCYAILVW.
OrthoDBiPOG091H0B4X.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMMLH_CUPPJ
AccessioniPrimary (citable) accession number: O51798
Secondary accession number(s): Q471R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.