Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ornithine carbamoyltransferase, catabolic

Gene

arcB

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

Pathwayi: L-arginine degradation via ADI pathway

This protein is involved in step 2 of the subpathway that synthesizes carbamoyl phosphate from L-arginine.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Arginine deiminase (arcA)
  2. Ornithine carbamoyltransferase, catabolic (arcB)
This subpathway is part of the pathway L-arginine degradation via ADI pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes carbamoyl phosphate from L-arginine, the pathway L-arginine degradation via ADI pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei83Carbamoyl phosphateUniRule annotation1
Binding sitei107Carbamoyl phosphateUniRule annotation1
Binding sitei166OrnithineUniRule annotation1
Binding sitei230OrnithineUniRule annotation1
Binding sitei314Carbamoyl phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processArginine metabolism

Enzyme and pathway databases

UniPathwayiUPA00254; UER00365

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase, catabolicUniRule annotation (EC:2.1.3.3UniRule annotation)
Short name:
OTCaseUniRule annotation
Gene namesi
Name:arcBUniRule annotation
Ordered Locus Names:BB_0842
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000001807 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001128901 – 327Ornithine carbamoyltransferase, catabolicAdd BLAST327

Proteomic databases

PRIDEiO51782

Interactioni

Protein-protein interaction databases

STRINGi224326.BB_0842

Structurei

3D structure databases

ProteinModelPortaliO51782
SMRiO51782
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 59Carbamoyl phosphate bindingUniRule annotation4
Regioni134 – 137Carbamoyl phosphate bindingUniRule annotation4
Regioni234 – 235Ornithine bindingUniRule annotation2
Regioni269 – 270Carbamoyl phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DBV Bacteria
COG0078 LUCA
KOiK00611
OMAiKHSKVFD

Family and domain databases

Gene3Di3.40.50.1370, 3 hits
HAMAPiMF_01109 OTCase, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
IPR002292 Orn/put_carbamltrans
IPR024904 OTCase_ArgI
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00102 OTCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00658 orni_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

O51782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNLRNRSFL NLLDFTSKDI KYLLDLSINL KKSKYAGIEV QKLKGKNIVI
60 70 80 90 100
IFEKDSTRTR CAFEIAAYDQ GANITYLGSK GNQMGSKESM IDTARVLGRM
110 120 130 140 150
YDAIGFRGFS QQTVECLANY SNVPVYNGLT DISHPTQILA DLMTIKEHKG
160 170 180 190 200
SLKGIKIVFC GDGRGNVANS LLKGCAIMGL DFRIFAPKEL FPDPDLTLKA
210 220 230 240 250
RSLALESGGK ITITDSKEEA VKCADVVYTD VWVSMGESNW EDRINLLKAY
260 270 280 290 300
QVNKEIMCMA KDDAIFMHCL PAFHDLNTVI GKDIFDKYGL DGIEVTEEIF
310 320
ESKNSVVFDV AENRVHTIKA IMVSTLG
Length:327
Mass (Da):36,452
Last modified:April 18, 2012 - v2
Checksum:iFDE230581CF7F46E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA Translation: AAC67190.2
PIRiA70205
RefSeqiNP_212976.2, NC_001318.1
WP_002657012.1, NC_001318.1

Genome annotation databases

EnsemblBacteriaiAAC67190; AAC67190; BB_0842
GeneIDi1195700
KEGGibbu:BB_0842
PATRICifig|224326.49.peg.1235

Similar proteinsi

Entry informationi

Entry nameiOTCC_BORBU
AccessioniPrimary (citable) accession number: O51782
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: April 18, 2012
Last modified: March 28, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health