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Protein

Ornithine carbamoyltransferase, catabolic

Gene

arcB

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

Pathwayi: L-arginine degradation via ADI pathway

This protein is involved in step 2 of the subpathway that synthesizes carbamoyl phosphate from L-arginine.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Arginine deiminase (arcA)
  2. Ornithine carbamoyltransferase, catabolic (arcB)
This subpathway is part of the pathway L-arginine degradation via ADI pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes carbamoyl phosphate from L-arginine, the pathway L-arginine degradation via ADI pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Carbamoyl phosphateUniRule annotation
Binding sitei72 – 721Carbamoyl phosphateUniRule annotation
Binding sitei83 – 831Carbamoyl phosphateUniRule annotation
Binding sitei107 – 1071Carbamoyl phosphateUniRule annotation
Binding sitei166 – 1661OrnithineBy similarity
Binding sitei230 – 2301OrnithineBy similarity
Binding sitei296 – 2961Carbamoyl phosphateUniRule annotation
Binding sitei314 – 3141Carbamoyl phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Arginine metabolism

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-852-MONOMER.
UniPathwayiUPA00254; UER00365.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase, catabolicUniRule annotation (EC:2.1.3.3UniRule annotation)
Short name:
OTCaseUniRule annotation
Gene namesi
Name:arcBUniRule annotation
Ordered Locus Names:BB_0842
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000001807 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Ornithine carbamoyltransferase, catabolicPRO_0000112890Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224326.BB_0842.

Structurei

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei31 – 311Important for structural integrityUniRule annotation
Sitei147 – 1471Important for structural integrityUniRule annotation

3D structure databases

ProteinModelPortaliO51782.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni56 – 605Carbamoyl phosphate bindingUniRule annotation
Regioni134 – 1374Carbamoyl phosphate bindingUniRule annotation
Regioni234 – 2352Ornithine bindingUniRule annotation
Regioni268 – 2714Carbamoyl phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DBV. Bacteria.
COG0078. LUCA.
KOiK00611.
OMAiDFRIFAP.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. OTCase_ArgI.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNLRNRSFL NLLDFTSKDI KYLLDLSINL KKSKYAGIEV QKLKGKNIVI
60 70 80 90 100
IFEKDSTRTR CAFEIAAYDQ GANITYLGSK GNQMGSKESM IDTARVLGRM
110 120 130 140 150
YDAIGFRGFS QQTVECLANY SNVPVYNGLT DISHPTQILA DLMTIKEHKG
160 170 180 190 200
SLKGIKIVFC GDGRGNVANS LLKGCAIMGL DFRIFAPKEL FPDPDLTLKA
210 220 230 240 250
RSLALESGGK ITITDSKEEA VKCADVVYTD VWVSMGESNW EDRINLLKAY
260 270 280 290 300
QVNKEIMCMA KDDAIFMHCL PAFHDLNTVI GKDIFDKYGL DGIEVTEEIF
310 320
ESKNSVVFDV AENRVHTIKA IMVSTLG
Length:327
Mass (Da):36,452
Last modified:April 18, 2012 - v2
Checksum:iFDE230581CF7F46E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC67190.2.
PIRiA70205.
RefSeqiNP_212976.2. NC_001318.1.
WP_002657012.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAC67190; AAC67190; BB_0842.
GeneIDi1195700.
KEGGibbu:BB_0842.
PATRICi20558351. VBIBorBur75917_1235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC67190.2.
PIRiA70205.
RefSeqiNP_212976.2. NC_001318.1.
WP_002657012.1. NC_001318.1.

3D structure databases

ProteinModelPortaliO51782.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224326.BB_0842.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67190; AAC67190; BB_0842.
GeneIDi1195700.
KEGGibbu:BB_0842.
PATRICi20558351. VBIBorBur75917_1235.

Phylogenomic databases

eggNOGiENOG4105DBV. Bacteria.
COG0078. LUCA.
KOiK00611.
OMAiDFRIFAP.

Enzyme and pathway databases

UniPathwayiUPA00254; UER00365.
BioCyciBBUR224326:G9SO-852-MONOMER.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. OTCase_ArgI.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry nameiOTCC_BORBU
AccessioniPrimary (citable) accession number: O51782
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: April 18, 2012
Last modified: February 17, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.