O51782 (OTCC_BORBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	BB_0842

Organism

Borrelia burgdorferi (Lyme disease spirochete)

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 328	328	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000112890
Regions
	Region	57 – 61	5	Carbamoyl phosphate binding By similarity
	Region	269 – 272	4	Ornithine binding By similarity
Sites
	Binding site	108	1	Carbamoyl phosphate By similarity
	Binding site	135	1	Carbamoyl phosphate By similarity
	Site	32	1	Important for structural integrity By similarity
	Site	148	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	O51782 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 7E3FBB82C5D2E5DF	FASTA	328	36,583
	10 20 30 40 50 60 MMYNLRNRSF LNLLDFTSKD IKYLLDLSIN LKKSKYAGIE VQKLKGKNIV IIFEKDSTRT 70 80 90 100 110 120 RCAFEIAAYD QGANITYLGS KGNQMGSKES MIDTARVLGR MYDAIGFRGF SQQTVECLAN 130 140 150 160 170 180 YSNVPVYNGL TDISHPTQIL ADLMTIKEHK GSLKGIKIVF CGDGRGNVAN SLLKGCAIMG 190 200 210 220 230 240 LDFRIFAPKE LFPDPDLTLK ARSLALESGG KITITDSKEE AVKCADVVYT DVWVSMGESN 250 260 270 280 290 300 WEDRINLLKA YQVNKEIMCM AKDDAIFMHC LPAFHDLNTV IGKDIFDKYG LDGIEVTEEI 310 320 FESKNSVVFD VAENRVHTIK AIMVSTLG

References

[1]

"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000783 Genomic DNA. Translation: AAC67190.1.
PIR	A70205.
RefSeq	NP_212976.1. NC_001318.1.
3D structure databases
ProteinModelPortal	O51782.
SMR	O51782. Positions 3-328.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000008610; EBBORP00000007940; EBBORG00000008609.
GeneID	1195700.
GenomeReviews	Gene locus BB_0842 in contig AE000783_GR.
KEGG	bbu:BB0842.
NMPDR	fig|224326.1.peg.1226.
PATRIC	20558351. VBIBorBur75917_1235.
TIGR	BB_0842.
Phylogenomic databases
GeneTree	EBGT00050000007528.
HOGENOM	HBG579429.
OMA	DFRIFAP.
PhylomeDB	O51782.
ProtClustDB	PRK04284.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0842-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_BORBU

Accession

Primary (citable) accession number: O51782

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program