O51781 (ARCA_BORBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine deiminase
Short name=ADI
EC=3.5.3.6

Alternative name(s):
Arginine dihydrolase
Short name=AD

Gene names

Name:	arcA
Ordered Locus Names:	BB_0841

Organism

Borrelia burgdorferi (Lyme disease spirochete)

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-arginine + H2O = L-citrulline + NH3. HAMAP MF_00242
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 1/2. HAMAP MF_00242
Subcellular location	Cytoplasm Potential HAMAP MF_00242.
Sequence similarities	Belongs to the arginine deiminase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arginine deiminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	Arginine deiminase HAMAP MF_00242		PRO_0000182203
Sites
	Active site	400	1	Amidino-cysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O51781 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: C2DF4F58E5848FAB	FASTA	410	46,844
	10 20 30 40 50 60 MEEEYLNPIN IFSEIGRLKK VLLHRPGEEL ENLTPLIMKN FLFDDIPYLK VARQEHEVFV 70 80 90 100 110 120 NILKDNSVEI EYVEDLVSEV LASSVALKNK FISQFILEAE IKTDGVINIL KDYFSNLTVD 130 140 150 160 170 180 NMVSKMISGV AREELKDCEF SLDDWVNGSS LFVIDPMPNV LFTRDPFASI GNGITINKMY 190 200 210 220 230 240 TKVRRRETIF AEYIFKYHSA YKENVPIWFN RWEETSLEGG DEFVLNKDLL VIGISERTEA 250 260 270 280 290 300 GSVEKLAASL FKNKAPFSTI LAFKIPKNRA YMHLDTVFTQ IDYSVFTSFT SDDMYFSIYV 310 320 330 340 350 360 LTYNSNSNKI NIKKEKAKLK DVLSFYLGRK IDIIKCAGGD LIHGAREQWN DGANVLAIAP 370 380 390 400 410 GEVIAYSRNH VTNKLFEENG IKVHRIPSSE LSRGRGGPRC MSMSLVREDI

References

[1]

"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000783 Genomic DNA. Translation: AAC67191.1.
PIR	H70204.
RefSeq	NP_212975.1. NC_001318.1.
3D structure databases
ProteinModelPortal	O51781.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000009171; EBBORP00000008501; EBBORG00000009170.
GeneID	1195699.
GenomeReviews	Gene locus BB_0841 in contig AE000783_GR.
KEGG	bbu:BB0841.
NMPDR	fig|224326.1.peg.1225.
PATRIC	20558349. VBIBorBur75917_1234.
TIGR	BB_0841.
Phylogenomic databases
GeneTree	EBGT00050000007000.
HOGENOM	HBG298398.
OMA	TDKTYVE.
PhylomeDB	O51781.
ProtClustDB	PRK01388.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0841-MONOMER.
Family and domain databases
HAMAP	MF_00242. Arg_deiminase. [Tree]
InterPro	IPR003198. Amidino_trans. IPR003876. Arg_deiminase. [Graphical view]
KO	K01478.
PANTHER	PTHR12737:SF9. PTHR12737:SF9. 1 hit.
Pfam	PF02274. Amidinotransf. 1 hit. [Graphical view]
PIRSF	PIRSF006356. Arg_deiminase. 1 hit.
PRINTS	PR01466. ARGDEIMINASE.
TIGRFAMs	TIGR01078. ArcA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARCA_BORBU

Accession

Primary (citable) accession number: O51781

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program