Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arginine deiminase

Gene

arcA

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine + H2O = L-citrulline + NH3.

Pathwayi: L-arginine degradation via ADI pathway

This protein is involved in step 1 of the subpathway that synthesizes carbamoyl phosphate from L-arginine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Arginine deiminase (arcA)
  2. Ornithine carbamoyltransferase, catabolic (arcB)
This subpathway is part of the pathway L-arginine degradation via ADI pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes carbamoyl phosphate from L-arginine, the pathway L-arginine degradation via ADI pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei400Amidino-cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism

Enzyme and pathway databases

UniPathwayiUPA00254; UER00364.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine deiminase (EC:3.5.3.6)
Short name:
ADI
Alternative name(s):
Arginine dihydrolase
Short name:
AD
Gene namesi
Name:arcA
Ordered Locus Names:BB_0841
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000001807 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001822031 – 410Arginine deiminaseAdd BLAST410

Proteomic databases

PRIDEiO51781.

Interactioni

Protein-protein interaction databases

STRINGi224326.BB_0841.

Structurei

3D structure databases

ProteinModelPortaliO51781.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginine deiminase family.Curated

Phylogenomic databases

eggNOGiENOG4105CEU. Bacteria.
COG2235. LUCA.
KOiK01478.
OMAiDVLEMHN.

Family and domain databases

HAMAPiMF_00242. Arg_deiminase. 1 hit.
InterProiIPR003876. Arg_deiminase.
IPR033199. DDAH/AD.
[Graphical view]
PANTHERiPTHR12737. PTHR12737. 3 hits.
PIRSFiPIRSF006356. Arg_deiminase. 1 hit.
PRINTSiPR01466. ARGDEIMINASE.
TIGRFAMsiTIGR01078. arcA. 1 hit.

Sequencei

Sequence statusi: Complete.

O51781-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEYLNPIN IFSEIGRLKK VLLHRPGEEL ENLTPLIMKN FLFDDIPYLK
60 70 80 90 100
VARQEHEVFV NILKDNSVEI EYVEDLVSEV LASSVALKNK FISQFILEAE
110 120 130 140 150
IKTDGVINIL KDYFSNLTVD NMVSKMISGV AREELKDCEF SLDDWVNGSS
160 170 180 190 200
LFVIDPMPNV LFTRDPFASI GNGITINKMY TKVRRRETIF AEYIFKYHSA
210 220 230 240 250
YKENVPIWFN RWEETSLEGG DEFVLNKDLL VIGISERTEA GSVEKLAASL
260 270 280 290 300
FKNKAPFSTI LAFKIPKNRA YMHLDTVFTQ IDYSVFTSFT SDDMYFSIYV
310 320 330 340 350
LTYNSNSNKI NIKKEKAKLK DVLSFYLGRK IDIIKCAGGD LIHGAREQWN
360 370 380 390 400
DGANVLAIAP GEVIAYSRNH VTNKLFEENG IKVHRIPSSE LSRGRGGPRC
410
MSMSLVREDI
Length:410
Mass (Da):46,844
Last modified:June 1, 1998 - v1
Checksum:iC2DF4F58E5848FAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC67191.1.
PIRiH70204.
RefSeqiNP_212975.1. NC_001318.1.
WP_002557431.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAC67191; AAC67191; BB_0841.
GeneIDi1195699.
KEGGibbu:BB_0841.
PATRICi20558349. VBIBorBur75917_1234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC67191.1.
PIRiH70204.
RefSeqiNP_212975.1. NC_001318.1.
WP_002557431.1. NC_001318.1.

3D structure databases

ProteinModelPortaliO51781.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224326.BB_0841.

Proteomic databases

PRIDEiO51781.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67191; AAC67191; BB_0841.
GeneIDi1195699.
KEGGibbu:BB_0841.
PATRICi20558349. VBIBorBur75917_1234.

Phylogenomic databases

eggNOGiENOG4105CEU. Bacteria.
COG2235. LUCA.
KOiK01478.
OMAiDVLEMHN.

Enzyme and pathway databases

UniPathwayiUPA00254; UER00364.

Family and domain databases

HAMAPiMF_00242. Arg_deiminase. 1 hit.
InterProiIPR003876. Arg_deiminase.
IPR033199. DDAH/AD.
[Graphical view]
PANTHERiPTHR12737. PTHR12737. 3 hits.
PIRSFiPIRSF006356. Arg_deiminase. 1 hit.
PRINTSiPR01466. ARGDEIMINASE.
TIGRFAMsiTIGR01078. arcA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARCA_BORBU
AccessioniPrimary (citable) accession number: O51781
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.