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O51745

- PNP_BORBU

UniProt

O51745 - PNP_BORBU

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi480 – 4801MagnesiumUniRule annotation
Metal bindingi486 – 4861MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-816-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:BB_0805
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Polyribonucleotide nucleotidyltransferasePRO_0000329540Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224326.BB0805.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini547 – 60660KHUniRule annotationAdd
BLAST
Domaini616 – 71196S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51745 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIGRDELVF ETGFMAKQAN GSVLATYGGS SVLATVCCSS NVREDLDFVP
60 70 80 90 100
LSVEYNEKYY AAGKIPGGFI KREGKPKDKE ILVSRLIDRP MRPLFDKRFG
110 120 130 140 150
REIQVIPTTL ATDQLNPPDI VGMNAAFTAV FLSDIPFNGP IAAVRMVYLN
160 170 180 190 200
GKFIVNPSFE EIHDSDLDIV VAGSLNGITM VEGGANEVGE DILLSAIDGA
210 220 230 240 250
HEYIKQICNA QKEFLDIVGK KEKLPLAFEE KIFEFKDELR DFVYADLKEA
260 270 280 290 300
CFVKGKLNRD KAITLLRNKS YEYFSSLEKL TDSNESLFHK AFDDFEKEIV
310 320 330 340 350
RSSILNDNIR TDGRTPNEIR DIISEVDILS RTHGSALFTR GETQALAVTT
360 370 380 390 400
LGTSIDEQIM DDIDGDKRLN FMLHYNFPPF SVGETGRLMT GRREIGHGHL
410 420 430 440 450
AQRALESMVP GKNDFPYTIR VVSEVLESNG SSSMATVCAG SMSLMSAGVP
460 470 480 490 500
VKGQVAGIAM GLISEGDKYV VLSDILGEED HLGDMDFKVA GTKNGITGFQ
510 520 530 540 550
MDIKIENVTK DLMRDALEQA RIGRIHILSI MNTVISNSRV GISKYAPKIV
560 570 580 590 600
QLQIDIDKIS LVIGSTGKTV KAITDEFEVK VQIEQNGKII LFGDDDFKMQ
610 620 630 640 650
KAKERIESIV REPKVGEIYE GTVKKINSFG AFIELTPAKE GFLSTRLKPR
660 670 680 690 700
DSKYGSGRFG NSNRYSRFGG GGENIRGNAG LVRPPKLEEG QRIKVKIIDI
710
DKFGKIDLEI VRDKDY
Length:716
Mass (Da):79,311
Last modified:April 18, 2012 - v2
Checksum:iC07CC2AE0CF2E8E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000783 Genomic DNA. Translation: AAC67149.2.
PIRiD70200.
RefSeqiNP_212939.2. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAC67149; AAC67149; BB_0805.
GeneIDi1195663.
KEGGibbu:BB_0805.
PATRICi20558275. VBIBorBur75917_1197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000783 Genomic DNA. Translation: AAC67149.2 .
PIRi D70200.
RefSeqi NP_212939.2. NC_001318.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224326.BB0805.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC67149 ; AAC67149 ; BB_0805 .
GeneIDi 1195663.
KEGGi bbu:BB_0805.
PATRICi 20558275. VBIBorBur75917_1197.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.

Enzyme and pathway databases

BioCyci BBUR224326:G9SO-816-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry nameiPNP_BORBU
AccessioniPrimary (citable) accession number: O51745
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 18, 2012
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3