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Protein

Threonine--tRNA ligase

Gene

thrS

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi278Zinc; catalyticBy similarity1
Metal bindingi329Zinc; catalyticBy similarity1
Metal bindingi455Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine--tRNA ligase (EC:6.1.1.3)
Alternative name(s):
Threonyl-tRNA synthetase
Short name:
ThrRS
Gene namesi
Name:thrS
Ordered Locus Names:BB_0720
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000001807 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001009451 – 581Threonine--tRNA ligaseAdd BLAST581

Proteomic databases

PRIDEiO51662.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO51662.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni185 – 478CatalyticAdd BLAST294

Sequence similaritiesi

Phylogenomic databases

OMAiFYYDFAY.

Family and domain databases

CDDicd00771. ThrRS_core. 1 hit.
Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR033728. ThrRS_core.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSiPR01047. TRNASYNTHTHR.
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51662-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKDLDKEDI LYKKRHSIAH VMAEAVLDLF PNTKIAIGPP IKDGFYYDFE
60 70 80 90 100
FKKQITEDSL LDIENRMREI LKTGSSFEKE IISVEQALEI FKDEPYKIDL
110 120 130 140 150
IKNFDLQNEV SIYKSHNFVD LCRGPHVENM NKIDPKAFKL TSIAGAYWRG
160 170 180 190 200
SEKNPMLTRI YGTLWNNEKE LRSYLNLREE IKKRDHRKLG KELDLFSIHE
210 220 230 240 250
EIGPGLVFFH PNGAKIRALI EDFWREEHSK NGYDILFTPH IGKSWLWQTS
260 270 280 290 300
GHLDFYKDSM FEKIEMDKSD YYLKPMNCPF HIAIYNTGKH SYRDLPFRWA
310 320 330 340 350
ELGTVYRYEK IGALHGMMRA RGFTQDDAHI ICTHSQVLDE IKEVLRFAIY
360 370 380 390 400
MWSKFGFSNP KAYLSTKPDK SVGNDSDWEM SLKVLEETLS DFEVPYEIDK
410 420 430 440 450
GGGAFYGPKI DLKIVDSLER EWQMSTIQFD FNLPERFNMT YTAEDGKEKR
460 470 480 490 500
PFMIHRALLG SIERFFGILV EHYGGAFPLW LSPVQVVIIP VNNIVEDYAI
510 520 530 540 550
KVFNKFKNEG IRIKLDNSSS RMNAKIREYQ AKKIPYMFII GEREATEERI
560 570 580
SIRTRTNEQI NGMKLDEALK FILFKIRDKE I
Length:581
Mass (Da):68,172
Last modified:June 1, 1998 - v1
Checksum:i52CEC7B50BEFC169
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. No translation available.
PIRiG70189.
RefSeqiWP_002665762.1. NC_001318.1.
YP_008686586.1. NC_001318.1.

Genome annotation databases

GeneIDi1195574.
KEGGibbu:BB_0720.
PATRICi20558095. VBIBorBur75917_1111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. No translation available.
PIRiG70189.
RefSeqiWP_002665762.1. NC_001318.1.
YP_008686586.1. NC_001318.1.

3D structure databases

ProteinModelPortaliO51662.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO51662.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1195574.
KEGGibbu:BB_0720.
PATRICi20558095. VBIBorBur75917_1111.

Phylogenomic databases

OMAiFYYDFAY.

Family and domain databases

CDDicd00771. ThrRS_core. 1 hit.
Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR033728. ThrRS_core.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSiPR01047. TRNASYNTHTHR.
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYT_BORBU
AccessioniPrimary (citable) accession number: O51662
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: October 5, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.