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O51648 (RNC_BORBU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Ordered Locus Names:BB_0705
OrganismBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) [Reference proteome] [HAMAP]
Taxonomic identifier224326 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity. HAMAP-Rule MF_00104

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00104

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00104.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245Ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000180376

Regions

Domain18 – 146129RNase III
Domain173 – 24270DRBM

Sites

Active site631 Potential
Active site1351 By similarity
Metal binding591Magnesium By similarity
Metal binding1321Magnesium By similarity
Metal binding1351Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
O51648 [UniParc].

Last modified April 18, 2012. Version 2.
Checksum: A6B10B0172E28C77

FASTA24527,811
        10         20         30         40         50         60 
MKKKSSDFCL CNERKSQLSK FLENLSIDFS NFDLLNTALC HSSYSNELDQ KSSNNERLEF 

        70         80         90        100        110        120 
LGDSVLNLII TDHLYKTYPN KSEGELSKAR SYIVSEDSLS NIAREINLGS YILLGRGEES 

       130        140        150        160        170        180 
NDGRNKKGIL ADAIEAFVGA IYLDSGFSRA TEFVVGLFDM YIRLMFNRGD FKDYKSLLQE 

       190        200        210        220        230        240 
YVQKKYKISP SYKLDKEIGP DHDKVFCVEL YVGENFISNG KGKSKKEAEM RAAEVALKAM 


ENINL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000783 Genomic DNA. Translation: AAC67040.2.
PIRH70187.
RefSeqNP_212839.2. NC_001318.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224326.BB0705.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC67040; AAC67040; BB_0705.
GeneID1195558.
KEGGbbu:BB_0705.
PATRIC20558061. VBIBorBur75917_1096.

Phylogenomic databases

eggNOGCOG0571.
KOK03685.
OMAAQKDPKT.

Enzyme and pathway databases

BioCycBBUR224326:G9SO-713-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. SSF69065. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_BORBU
AccessionPrimary (citable) accession number: O51648
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 18, 2012
Last modified: May 14, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families