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Protein

Elongation factor G 2

Gene

fusB

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178GTPBy similarity
Nucleotide bindingi74 – 785GTPBy similarity
Nucleotide bindingi128 – 1314GTPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-701-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor G 2
Short name:
EF-G 2
Gene namesi
Name:fusB
Synonyms:fus2
Ordered Locus Names:BB_0691
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000001807 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669Elongation factor G 2PRO_0000091081Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224326.BB_0691.

Structurei

3D structure databases

ProteinModelPortaliO51634.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 276276tr-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CEJ. Bacteria.
COG0480. LUCA.
KOiK02355.
OMAiFTMEFSY.
OrthoDBiEOG6X6RBF.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIRNIGIMA HIDAGKTTTT ERIIYYTGKS HKMGDVDSGN TITDWMPQEQ
60 70 80 90 100
ERGITISSAA ITCHWKDCQI NIIDTPGHVD FTAEVERSLR VLDGGIVIFS
110 120 130 140 150
AVDGIQAQTE TVWKQAEKYE IPRLAYVNKM DRIGADFFKV VGDIENKFKT
160 170 180 190 200
IPLVLQIPIG NESNFEGVVD IILNKELHFS MENGIPKLTY SQIREEFIEK
210 220 230 240 250
VILFKKKLID ILSQFSEEIT QLFLEDKEIG LDIIKREIRR GTISRFIIPV
260 270 280 290 300
LMGTSLKNIG IEPLIDSIVD YLPSPFEKSF SAFSLDTNKK ILVDPNENKK
310 320 330 340 350
LSALVFKVQY SSVIASHLYF VRVYSGEINP NKKIINASNG KREKFTKIFR
360 370 380 390 400
VFSNKNEQID FVKTGDIGAV LGLKFSVTGD TLVEENNNVL LEAVMFPEPV
410 420 430 440 450
VLMSVEPERS SDEVRLKEIF EIISKEDPTF SYSESKETGQ LIISGMGELH
460 470 480 490 500
LEIILTRIKD EFNLNVYTGK PQVSYRESAG KIVKEVFEFN NIFAGKNIDF
510 520 530 540 550
KIGMIIKPLS RGAGNKIDFE CGIEPVIKSA ILRGITSAFV SGIFGYPIID
560 570 580 590 600
INVSIFSIVC GANKISESAF ESISGFAFHS IFQKSDPIRL EPIMLLEIRT
610 620 630 640 650
PIEHTGEIIS TLNVMGGVIH SVSNIGEYDL IKSEAAFEKL FGYASILRSS
660
TKGRGSFTME FSYFKEKLS
Length:669
Mass (Da):75,057
Last modified:June 1, 1998 - v1
Checksum:i20BEA5691C8BDAC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC67051.1.
PIRiB70186.
RefSeqiNP_212825.1. NC_001318.1.
WP_010889801.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAC67051; AAC67051; BB_0691.
GeneIDi1195544.
KEGGibbu:BB_0691.
PATRICi20558033. VBIBorBur75917_1082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC67051.1.
PIRiB70186.
RefSeqiNP_212825.1. NC_001318.1.
WP_010889801.1. NC_001318.1.

3D structure databases

ProteinModelPortaliO51634.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224326.BB_0691.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67051; AAC67051; BB_0691.
GeneIDi1195544.
KEGGibbu:BB_0691.
PATRICi20558033. VBIBorBur75917_1082.

Phylogenomic databases

eggNOGiENOG4105CEJ. Bacteria.
COG0480. LUCA.
KOiK02355.
OMAiFTMEFSY.
OrthoDBiEOG6X6RBF.

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-701-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry nameiEFG2_BORBU
AccessioniPrimary (citable) accession number: O51634
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: February 17, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.