Reviewed, UniProtKB/Swiss-Prot O51628 (HMDH_BORBU)

Names and origin

Protein names

Recommended name:
    Probable 3-hydroxy-3-methylglutaryl-coenzyme A reductase
      Short name=HMG-CoA reductase
    EC=1.1.1.88

Gene names

Ordered Locus Names:

BB_0685

Organism

Borrelia burgdorferi (Lyme disease spirochete) [Complete proteome] [HAMAP]

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Converts HMG-CoA to mevalonate By similarity.
Catalytic activity	(R)-mevalonate + CoA + 2 NAD(+) = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH.
Pathway	Metabolic intermediate metabolism; mevalonic acid degradation; HMG-CoA from (R)-mevalonic acid: step 1/1.
Sequence similarities	Belongs to the HMG-CoA reductase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro hydroxymethylglutaryl-CoA reductase (NADPH) activity Inferred from electronic annotation. Source: InterPro hydroxymethylglutaryl-CoA reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 431	431	Probable 3-hydroxy-3-methylglutaryl-coenzyme A reductase		PRO_0000114466
Sites
	Active site	85	1	Charge relay system By similarity
	Active site	278	1	Charge relay system By similarity
	Active site	375	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	O51628-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: A98DA9099AB0CDB4	FASTA	431	48,922
	10 20 30 40 50 60 MNLESLSSFM ELSKNFRHKS VLEKRQEIKS FLELSYKDFF YNNANEDFLF NMIENYIGYL 70 80 90 100 110 120 SFPIGIVKNL KINGKYYSLP IATEESSVVA ALNFAAKILE NADLRYSLGE VLGISQIYIK 130 140 150 160 170 180 SEKDLSKIFV DLGDKIKTWI EPLLTNMNQR GGGFRRLSTR HIKELGIQKL NIYVDTCDAM 190 200 210 220 230 240 GANLLNSIAE RVAEFIFLEF GYECVLKVLS NDISEFTAKA RFVLDFKHLL PGKEDSWNLA 250 260 270 280 290 300 KKIELISSIG FYEEERAVTN NKGIMNGITG VCLATFNDTR ALEASVHKFA SKSGKYFPLS 310 320 330 340 350 360 KFYTTDNALV GEIEIPLQVG TKGGVISFNE ASILSFKIMN VNSKSEFIGI LSCVGLASNF 370 380 390 400 410 420 AALRALAFNG IQKGHMRLHV NKILHLLKTK YNISDFEKDK LLLEMERMNI YSFDFAFKIL 430 KKIRLENENK V

References

[1]

"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000783 Genomic DNA. Translation: AAC67032.1.
PIR	D70185.
RefSeq	NP_212819.1.
3D structure databases
HSSP	HSSP built from PDB template 1QAY based on UniProtKB P13702.
ModBase	Search...
Genome annotation databases
GeneID	1195537.
GenomeReviews	Gene locus BB_0685 in contig AE000783_GR.
KEGG	bbu:BB0685.
NMPDR	fig|224326.1.peg.1069.
TIGR	BB_0685.
Phylogenomic databases
HOGENOM	O51628.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0685-MON.
Family and domain databases
InterPro	IPR002202. HMG_CoA_Rdtase_cat. IPR004553. HMG_CoA_Rdtase_II_bac/I_arc. [Graphical view]
Gene3D	G3DSA:3.90.770.10. HMG-CoA_red. 1 hit.
PANTHER	PTHR10572. HMG-CoA_red. 1 hit.
PRINTS	PR00071. HMGCOARDTASE.
TIGRFAMs	TIGR00532. HMG_CoA_R_NAD. 1 hit.
PROSITE	PS00066. HMG_COA_REDUCTASE_1. False negative. PS00318. HMG_COA_REDUCTASE_2. False negative. PS01192. HMG_COA_REDUCTASE_3. False negative. PS50065. HMG_COA_REDUCTASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HMDH_BORBU

Accession

Primary (citable) accession number: O51628

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 1, 1998
Last modified:	November 25, 2008
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)