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Protein

Probable 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene

BB_0685

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts HMG-CoA to mevalonate.By similarity

Catalytic activityi

(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH.

Pathwayi: (R)-mevalonate degradation

This protein is involved in step 1 of the subpathway that synthesizes (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable 3-hydroxy-3-methylglutaryl-coenzyme A reductase (BB_0685)
This subpathway is part of the pathway (R)-mevalonate degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate, the pathway (R)-mevalonate degradation and in Metabolic intermediate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85Charge relay systemBy similarity1
Active sitei278Charge relay systemBy similarity1
Active sitei375Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00257; UER00367.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC:1.1.1.88)
Short name:
HMG-CoA reductase
Gene namesi
Ordered Locus Names:BB_0685
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000001807 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001144661 – 431Probable 3-hydroxy-3-methylglutaryl-coenzyme A reductaseAdd BLAST431

Proteomic databases

PRIDEiO51628.

Interactioni

Protein-protein interaction databases

STRINGi224326.BB_0685.

Structurei

3D structure databases

ProteinModelPortaliO51628.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMG-CoA reductase family.Curated

Phylogenomic databases

eggNOGiENOG4107EEU. Bacteria.
COG1257. LUCA.
KOiK00054.
OMAiATGNDFR.

Family and domain databases

CDDicd00644. HMG-CoA_reductase_classII. 1 hit.
Gene3Di3.30.70.420. 1 hit.
3.90.770.10. 2 hits.
InterProiIPR002202. HMG_CoA_Rdtase.
IPR004553. HMG_CoA_Rdtase_bac-typ.
IPR023074. HMG_CoA_Rdtase_cat.
IPR009023. HMG_CoA_Rdtase_NAD(P)-bd_dom.
IPR009029. HMG_CoA_Rdtase_sub-bd_dom.
[Graphical view]
PANTHERiPTHR10572. PTHR10572. 1 hit.
PfamiPF00368. HMG-CoA_red. 1 hit.
[Graphical view]
PRINTSiPR00071. HMGCOARDTASE.
SUPFAMiSSF55035. SSF55035. 1 hit.
SSF56542. SSF56542. 2 hits.
TIGRFAMsiTIGR00532. HMG_CoA_R_NAD. 1 hit.
PROSITEiPS50065. HMG_COA_REDUCTASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLESLSSFM ELSKNFRHKS VLEKRQEIKS FLELSYKDFF YNNANEDFLF
60 70 80 90 100
NMIENYIGYL SFPIGIVKNL KINGKYYSLP IATEESSVVA ALNFAAKILE
110 120 130 140 150
NADLRYSLGE VLGISQIYIK SEKDLSKIFV DLGDKIKTWI EPLLTNMNQR
160 170 180 190 200
GGGFRRLSTR HIKELGIQKL NIYVDTCDAM GANLLNSIAE RVAEFIFLEF
210 220 230 240 250
GYECVLKVLS NDISEFTAKA RFVLDFKHLL PGKEDSWNLA KKIELISSIG
260 270 280 290 300
FYEEERAVTN NKGIMNGITG VCLATFNDTR ALEASVHKFA SKSGKYFPLS
310 320 330 340 350
KFYTTDNALV GEIEIPLQVG TKGGVISFNE ASILSFKIMN VNSKSEFIGI
360 370 380 390 400
LSCVGLASNF AALRALAFNG IQKGHMRLHV NKILHLLKTK YNISDFEKDK
410 420 430
LLLEMERMNI YSFDFAFKIL KKIRLENENK V
Length:431
Mass (Da):48,922
Last modified:June 1, 1998 - v1
Checksum:iA98DA9099AB0CDB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC67032.1.
PIRiD70185.
RefSeqiNP_212819.1. NC_001318.1.
WP_010889799.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAC67032; AAC67032; BB_0685.
GeneIDi1195537.
KEGGibbu:BB_0685.
PATRICi20558019. VBIBorBur75917_1076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC67032.1.
PIRiD70185.
RefSeqiNP_212819.1. NC_001318.1.
WP_010889799.1. NC_001318.1.

3D structure databases

ProteinModelPortaliO51628.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224326.BB_0685.

Proteomic databases

PRIDEiO51628.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67032; AAC67032; BB_0685.
GeneIDi1195537.
KEGGibbu:BB_0685.
PATRICi20558019. VBIBorBur75917_1076.

Phylogenomic databases

eggNOGiENOG4107EEU. Bacteria.
COG1257. LUCA.
KOiK00054.
OMAiATGNDFR.

Enzyme and pathway databases

UniPathwayiUPA00257; UER00367.

Family and domain databases

CDDicd00644. HMG-CoA_reductase_classII. 1 hit.
Gene3Di3.30.70.420. 1 hit.
3.90.770.10. 2 hits.
InterProiIPR002202. HMG_CoA_Rdtase.
IPR004553. HMG_CoA_Rdtase_bac-typ.
IPR023074. HMG_CoA_Rdtase_cat.
IPR009023. HMG_CoA_Rdtase_NAD(P)-bd_dom.
IPR009029. HMG_CoA_Rdtase_sub-bd_dom.
[Graphical view]
PANTHERiPTHR10572. PTHR10572. 1 hit.
PfamiPF00368. HMG-CoA_red. 1 hit.
[Graphical view]
PRINTSiPR00071. HMGCOARDTASE.
SUPFAMiSSF55035. SSF55035. 1 hit.
SSF56542. SSF56542. 2 hits.
TIGRFAMsiTIGR00532. HMG_CoA_R_NAD. 1 hit.
PROSITEiPS50065. HMG_COA_REDUCTASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMDH_BORBU
AccessioniPrimary (citable) accession number: O51628
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.