O51627 (IDI2_BORBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Isopentenyl-diphosphate delta-isomerase
Short name=IPP isomerase
EC=5.3.3.2

Alternative name(s):
Isopentenyl pyrophosphate isomerase

Gene names

Name:	fni
Ordered Locus Names:	BB_0684

Organism

Borrelia burgdorferi (Lyme disease spirochete)

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00354
Catalytic activity	Isopentenyl diphosphate = dimethylallyl diphosphate. HAMAP MF_00354
Cofactor	FMN By similarity. HAMAP MF_00354 NADPH By similarity. HAMAP MF_00354
Subcellular location	Cytoplasm By similarity HAMAP MF_00354.
Sequence similarities	Belongs to the IPP isomerase type 2 family.
Sequence caution	The sequence AAC67033.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Cellular component	Cytoplasm
Ligand	FMN Flavoprotein NADP
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro isopentenyl-diphosphate delta-isomerase activity Inferred from electronic annotation. Source: EC oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Isopentenyl-diphosphate delta-isomerase HAMAP MF_00354		PRO_0000134405

Sequences

	Sequence		Length	Mass (Da)
	O51627 [UniParc]. Last modified April 27, 2001. Version 2. Checksum: D7D2BA8BEB12A2A4	FASTA	354	39,258
	10 20 30 40 50 60 MGIEPNILEN KKRHIEICLN KNDVKGGCNF LKFIKLKHNA LSDFNFSEIN IKEEIFGYNI 70 80 90 100 110 120 SMPVFISSMT GGSKEGNDFN KSLVRIANYL KIPIGLGSFK LLFKYPEYIR DFTLKRYAHN 130 140 150 160 170 180 IPLFANVGAV QIVEFGISKI AEMIKRLEVD AIIVHLNAGQ ELMKVDGDRN FKGIRESIAK 190 200 210 220 230 240 LSDFLSVPLI VKETGFGISP KDVKELFSLG ASYVDLAGSG GTNWILVEGM KSNNLNIASC 250 260 270 280 290 300 FSDWGIPSVF TLLSIDDSLK ANIFASGGYE TGMDIAKGIA LGARLIGVAA VVLRAFYDSG 310 320 330 340 350 EDAVFGLFSD YEHILKMSMF LSGSKSLLEF RNNKYFLSSY LLDELGVFKQ FYGT

References

[1]

"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000783 Genomic DNA. Translation: AAC67033.1. Different initiation.
PIR	C70185.
RefSeq	NP_212818.1. NC_001318.1.
3D structure databases
ProteinModelPortal	O51627.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000008933; EBBORP00000008263; EBBORG00000008932.
GeneID	1195536.
GenomeReviews	Gene locus BB_0684 in contig AE000783_GR.
KEGG	bbu:BB0684.
NMPDR	fig|224326.1.peg.1068.
PATRIC	20558017. VBIBorBur75917_1075.
TIGR	BB_0684.
Phylogenomic databases
GeneTree	EBGT00050000007152.
HOGENOM	HBG354479.
OMA	GSQRAAI.
ProtClustDB	PRK05437.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0684-MONOMER.
Family and domain databases
HAMAP	MF_00354. Idi_2. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR000262. FMN-dep_DH. IPR011179. IPdP_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01823.
PANTHER	PTHR10578:SF3. IPdP_isomerase. 1 hit.
Pfam	PF01070. FMN_dh. 2 hits. [Graphical view]
PIRSF	PIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMs	TIGR02151. IPP_isom_2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IDI2_BORBU

Accession

Primary (citable) accession number: O51627

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 27, 2001
Last modified:	January 25, 2012
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program