O51601 (RPIA_BORBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribose-5-phosphate isomerase A
EC=5.3.1.6

Alternative name(s):
Phosphoriboisomerase A
Short name=PRI

Gene names

Name:	rpiA
Ordered Locus Names:	BB_0657

Organism

Borrelia burgdorferi (Lyme disease spirochete)

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-ribose 5-phosphate = D-ribulose 5-phosphate. HAMAP MF_00170
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. HAMAP MF_00170
Sequence similarities	Belongs to the ribose 5-phosphate isomerase family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt, non-oxidative branch Inferred from electronic annotation. Source: InterPro
Molecular function	ribose-5-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 228	228	Ribose-5-phosphate isomerase A HAMAP MF_00170		PRO_0000158392

Sequences

	Sequence		Length	Mass (Da)
	O51601 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 4051FC370FF7C76F	FASTA	228	25,885
	10 20 30 40 50 60 MENQKILVAK HAIDHYIKSN MNLGIGTGTT IYYAIKYLSE KIKSGSLKNL KFYTTSSDTK 70 80 90 100 110 120 YLLSKEQIPY ESNFSKLNKN LDIAIDGADE ILLEKKSLIK GMGGAHLMEK VIAYNSETLL 130 140 150 160 170 180 IIADETKIVK KLGTKMPIPI EVAQNAVGFI MTRLEEMNLE ATLRICKEKK GPTITDNNNY 190 200 210 220 ILDVKMHVEN PEGTEKYFKL FPGILEIGIF NHKNTRIVYY QDKQIKEA

References

[1]

"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000783 Genomic DNA. Translation: AAC67008.1.
PIR	H70181.
RefSeq	NP_212791.1. NC_001318.1.
3D structure databases
ProteinModelPortal	O51601.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000008368; EBBORP00000007698; EBBORG00000008367.
GeneID	1195509.
GenomeReviews	Gene locus BB_0657 in contig AE000783_GR.
KEGG	bbu:BB0657.
NMPDR	fig|224326.1.peg.1041.
PATRIC	20557963. VBIBorBur75917_1048.
TIGR	BB_0657.
Phylogenomic databases
GeneTree	EBGT00050000007573.
HOGENOM	HBG515603.
OMA	CLAERVR.
PhylomeDB	O51601.
ProtClustDB	CLSK507738.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0657-MONOMER.
Family and domain databases
HAMAP	MF_00170. Rib_5P_isom_A. [Tree]
InterPro	IPR004788. Ribose5P_isomerase_typA. IPR020672. Ribose5P_isomerase_typA_subgr. [Graphical view]
KO	K01807.
PANTHER	PTHR11934. RpiA. 1 hit.
Pfam	PF06026. Rib_5-P_isom_A. 1 hit. [Graphical view]
TIGRFAMs	TIGR00021. RpiA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RPIA_BORBU

Accession

Primary (citable) accession number: O51601

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program