Reviewed, UniProtKB/Swiss-Prot O51581 (G6PD_BORBU)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	zwf
Ordered Locus Names:	BB_0636

Organism

Borrelia burgdorferi (Lyme disease spirochete) [Complete proteome] [HAMAP]

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068111
Sites
	Active site	234	1	Proton acceptor By similarity
	Binding site	17	1	NADP By similarity
	Binding site	48	1	NADP By similarity
	Binding site	172	1	Substrate By similarity
	Binding site	176	1	Substrate By similarity
	Binding site	339	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O51581-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 4DDBCE2861161C8A	FASTA	478	56,113
	10 20 30 40 50 60 MKERSVSNFD IVIFGVTGNL SRKKLIPSLF NLFKNKCISN FRVIGFSRKI FTDKEFRLYI 70 80 90 100 110 120 KDSLWQEETD SLIEIFLNFF VYVFGDFNEK ESYKNLFKFL DRSRETIYYL STSPAFYGPI 130 140 150 160 170 180 INHLKKYFLS EKLTLSKIVL EKPFGSSLET AKKLNSLLYS AFKEDQIYRI DHYLGKETVQ 190 200 210 220 230 240 NIFTFRFGNS IFENIWNNRY VDFVQITVAE ELGLDGRVEY YDSVGALKDM VQNHILQLLS 250 260 270 280 290 300 LVAMESPIKF DSEFIHDEKV KVLKSLRKIS KEDIKNYIVK GQYIGSQVQG VFKKGYKDET 310 320 330 340 350 360 EFLGNSNTET YLAMKVFINN WRWSGVPFYL RTGKGLARKF SEIYIQFKKP SFTLFNNSSV 370 380 390 400 410 420 DFSNALIFRI QPRDGIEIKF NTKKPGYNYE IQTANMEFSY HGAFKRLFDE AYERLLLDAF 430 440 450 460 470 LGDGTLYATS DEIESSWEFV SDIANKWADI EICNYFYGSE GPKEIDSILE KDHFWRKI

References

[1]

"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000783 Genomic DNA. Translation: AAB91531.1.
PIR	C70179.
RefSeq	NP_212770.1.
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
ModBase	Search...
Genome annotation databases
GeneID	1195488.
GenomeReviews	Gene locus BB_0636 in contig AE000783_GR.
KEGG	bbu:BB0636.
NMPDR	fig|224326.1.peg.1020.
TIGR	BB_0636.
Phylogenomic databases
HOGENOM	O51581.
OMA	WADIEIC.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0636-MON.
BRENDA	1.1.1.49. 142596.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DH. IPR019796. Glc-6-P_DH_AS. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
ProDom	PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_BORBU

Accession

Primary (citable) accession number: O51581

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 1, 1998
Last modified:	November 3, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)