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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei48NADPUniRule annotation1
Binding sitei142NADPUniRule annotation1
Binding sitei172SubstrateUniRule annotation1
Binding sitei176SubstrateUniRule annotation1
Binding sitei210SubstrateUniRule annotation1
Binding sitei229SubstrateUniRule annotation1
Active sitei234Proton acceptorUniRule annotation1
Binding sitei334SubstrateUniRule annotation1
Binding sitei339SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi86 – 87NADPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:BB_0636
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000001807 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681111 – 478Glucose-6-phosphate 1-dehydrogenaseAdd BLAST478

Proteomic databases

PRIDEiO51581.

Interactioni

Protein-protein interaction databases

STRINGi224326.BB_0636.

Structurei

3D structure databases

ProteinModelPortaliO51581.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D8W. Bacteria.
COG0364. LUCA.
KOiK00036.
OMAiDNIYENT.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKERSVSNFD IVIFGVTGNL SRKKLIPSLF NLFKNKCISN FRVIGFSRKI
60 70 80 90 100
FTDKEFRLYI KDSLWQEETD SLIEIFLNFF VYVFGDFNEK ESYKNLFKFL
110 120 130 140 150
DRSRETIYYL STSPAFYGPI INHLKKYFLS EKLTLSKIVL EKPFGSSLET
160 170 180 190 200
AKKLNSLLYS AFKEDQIYRI DHYLGKETVQ NIFTFRFGNS IFENIWNNRY
210 220 230 240 250
VDFVQITVAE ELGLDGRVEY YDSVGALKDM VQNHILQLLS LVAMESPIKF
260 270 280 290 300
DSEFIHDEKV KVLKSLRKIS KEDIKNYIVK GQYIGSQVQG VFKKGYKDET
310 320 330 340 350
EFLGNSNTET YLAMKVFINN WRWSGVPFYL RTGKGLARKF SEIYIQFKKP
360 370 380 390 400
SFTLFNNSSV DFSNALIFRI QPRDGIEIKF NTKKPGYNYE IQTANMEFSY
410 420 430 440 450
HGAFKRLFDE AYERLLLDAF LGDGTLYATS DEIESSWEFV SDIANKWADI
460 470
EICNYFYGSE GPKEIDSILE KDHFWRKI
Length:478
Mass (Da):56,113
Last modified:June 1, 1998 - v1
Checksum:i4DDBCE2861161C8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAB91531.1.
PIRiC70179.
RefSeqiNP_212770.1. NC_001318.1.
WP_002656376.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAB91531; AAB91531; BB_0636.
GeneIDi1195488.
KEGGibbu:BB_0636.
PATRICi20557921. VBIBorBur75917_1027.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAB91531.1.
PIRiC70179.
RefSeqiNP_212770.1. NC_001318.1.
WP_002656376.1. NC_001318.1.

3D structure databases

ProteinModelPortaliO51581.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224326.BB_0636.

Proteomic databases

PRIDEiO51581.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB91531; AAB91531; BB_0636.
GeneIDi1195488.
KEGGibbu:BB_0636.
PATRICi20557921. VBIBorBur75917_1027.

Phylogenomic databases

eggNOGiENOG4105D8W. Bacteria.
COG0364. LUCA.
KOiK00036.
OMAiDNIYENT.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PD_BORBU
AccessioniPrimary (citable) accession number: O51581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.