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O51581

- G6PD_BORBU

UniProt

O51581 - G6PD_BORBU

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei48 – 481NADPUniRule annotation
    Binding sitei142 – 1421NADPUniRule annotation
    Binding sitei172 – 1721SubstrateUniRule annotation
    Binding sitei176 – 1761SubstrateUniRule annotation
    Binding sitei210 – 2101SubstrateUniRule annotation
    Binding sitei229 – 2291SubstrateUniRule annotation
    Active sitei234 – 2341Proton acceptorUniRule annotation
    Binding sitei334 – 3341SubstrateUniRule annotation
    Binding sitei339 – 3391SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi86 – 872NADPUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciBBUR224326:G9SO-645-MONOMER.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:BB_0636
    OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
    Taxonomic identifieri224326 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
    ProteomesiUP000001807: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 478478Glucose-6-phosphate 1-dehydrogenasePRO_0000068111Add
    BLAST

    Proteomic databases

    PRIDEiO51581.

    Interactioni

    Protein-protein interaction databases

    STRINGi224326.BB0636.

    Structurei

    3D structure databases

    ProteinModelPortaliO51581.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    KOiK00036.
    OMAiWARSLKP.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O51581-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKERSVSNFD IVIFGVTGNL SRKKLIPSLF NLFKNKCISN FRVIGFSRKI    50
    FTDKEFRLYI KDSLWQEETD SLIEIFLNFF VYVFGDFNEK ESYKNLFKFL 100
    DRSRETIYYL STSPAFYGPI INHLKKYFLS EKLTLSKIVL EKPFGSSLET 150
    AKKLNSLLYS AFKEDQIYRI DHYLGKETVQ NIFTFRFGNS IFENIWNNRY 200
    VDFVQITVAE ELGLDGRVEY YDSVGALKDM VQNHILQLLS LVAMESPIKF 250
    DSEFIHDEKV KVLKSLRKIS KEDIKNYIVK GQYIGSQVQG VFKKGYKDET 300
    EFLGNSNTET YLAMKVFINN WRWSGVPFYL RTGKGLARKF SEIYIQFKKP 350
    SFTLFNNSSV DFSNALIFRI QPRDGIEIKF NTKKPGYNYE IQTANMEFSY 400
    HGAFKRLFDE AYERLLLDAF LGDGTLYATS DEIESSWEFV SDIANKWADI 450
    EICNYFYGSE GPKEIDSILE KDHFWRKI 478
    Length:478
    Mass (Da):56,113
    Last modified:June 1, 1998 - v1
    Checksum:i4DDBCE2861161C8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000783 Genomic DNA. Translation: AAB91531.1.
    PIRiC70179.
    RefSeqiNP_212770.1. NC_001318.1.

    Genome annotation databases

    EnsemblBacteriaiAAB91531; AAB91531; BB_0636.
    GeneIDi1195488.
    KEGGibbu:BB_0636.
    PATRICi20557921. VBIBorBur75917_1027.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000783 Genomic DNA. Translation: AAB91531.1 .
    PIRi C70179.
    RefSeqi NP_212770.1. NC_001318.1.

    3D structure databases

    ProteinModelPortali O51581.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224326.BB0636.

    Proteomic databases

    PRIDEi O51581.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB91531 ; AAB91531 ; BB_0636 .
    GeneIDi 1195488.
    KEGGi bbu:BB_0636.
    PATRICi 20557921. VBIBorBur75917_1027.

    Phylogenomic databases

    eggNOGi COG0364.
    KOi K00036.
    OMAi WARSLKP.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    BioCyci BBUR224326:G9SO-645-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

    Entry informationi

    Entry nameiG6PD_BORBU
    AccessioniPrimary (citable) accession number: O51581
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3