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O51581

- G6PD_BORBU

UniProt

O51581 - G6PD_BORBU

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Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
zwf, BB_0636
Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481NADP By similarity
Binding sitei142 – 1421NADP By similarity
Binding sitei172 – 1721Substrate By similarity
Binding sitei176 – 1761Substrate By similarity
Binding sitei210 – 2101Substrate By similarity
Binding sitei229 – 2291Substrate By similarity
Active sitei234 – 2341Proton acceptor By similarity
Binding sitei334 – 3341Substrate By similarity
Binding sitei339 – 3391Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi86 – 872NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: UniProtKB-HAMAP
  2. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-645-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:zwf
Ordered Locus Names:BB_0636
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Glucose-6-phosphate 1-dehydrogenaseUniRule annotation
PRO_0000068111Add
BLAST

Proteomic databases

PRIDEiO51581.

Interactioni

Protein-protein interaction databases

STRINGi224326.BB0636.

Structurei

3D structure databases

ProteinModelPortaliO51581.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
KOiK00036.
OMAiWARSLKP.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51581-1 [UniParc]FASTAAdd to Basket

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MKERSVSNFD IVIFGVTGNL SRKKLIPSLF NLFKNKCISN FRVIGFSRKI    50
FTDKEFRLYI KDSLWQEETD SLIEIFLNFF VYVFGDFNEK ESYKNLFKFL 100
DRSRETIYYL STSPAFYGPI INHLKKYFLS EKLTLSKIVL EKPFGSSLET 150
AKKLNSLLYS AFKEDQIYRI DHYLGKETVQ NIFTFRFGNS IFENIWNNRY 200
VDFVQITVAE ELGLDGRVEY YDSVGALKDM VQNHILQLLS LVAMESPIKF 250
DSEFIHDEKV KVLKSLRKIS KEDIKNYIVK GQYIGSQVQG VFKKGYKDET 300
EFLGNSNTET YLAMKVFINN WRWSGVPFYL RTGKGLARKF SEIYIQFKKP 350
SFTLFNNSSV DFSNALIFRI QPRDGIEIKF NTKKPGYNYE IQTANMEFSY 400
HGAFKRLFDE AYERLLLDAF LGDGTLYATS DEIESSWEFV SDIANKWADI 450
EICNYFYGSE GPKEIDSILE KDHFWRKI 478
Length:478
Mass (Da):56,113
Last modified:June 1, 1998 - v1
Checksum:i4DDBCE2861161C8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000783 Genomic DNA. Translation: AAB91531.1.
PIRiC70179.
RefSeqiNP_212770.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAB91531; AAB91531; BB_0636.
GeneIDi1195488.
KEGGibbu:BB_0636.
PATRICi20557921. VBIBorBur75917_1027.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000783 Genomic DNA. Translation: AAB91531.1 .
PIRi C70179.
RefSeqi NP_212770.1. NC_001318.1.

3D structure databases

ProteinModelPortali O51581.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224326.BB0636.

Proteomic databases

PRIDEi O51581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB91531 ; AAB91531 ; BB_0636 .
GeneIDi 1195488.
KEGGi bbu:BB_0636.
PATRICi 20557921. VBIBorBur75917_1027.

Phylogenomic databases

eggNOGi COG0364.
KOi K00036.
OMAi WARSLKP.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci BBUR224326:G9SO-645-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry nameiG6PD_BORBU
AccessioniPrimary (citable) accession number: O51581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: May 14, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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