O51575 (K1PF_BORBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-phosphofructokinase
EC=2.7.1.56

Alternative name(s):
Fructose 1-phosphate kinase

Gene names

Name:	fruK
Ordered Locus Names:	BB_0630

Organism

Borrelia burgdorferi (Lyme disease spirochete)

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate.
Sequence similarities	Belongs to the carbohydrate kinase pfkB family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	1-phosphofructokinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	1-phosphofructokinase		PRO_0000080075

Sequences

	Sequence		Length	Mass (Da)
	O51575 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 94DF27BD61246D39	FASTA	307	33,595
	10 20 30 40 50 60 MIYTLTLNPS VDYKIVLKEF QEESLNYALN NNFFAGGKGI NVSTVLKNLG KPSTALGFLG 70 80 90 100 110 120 GFTGDYIRFS LDSRGIKNDF IKIKYDTRLN IKMIANGRET EINANSPDIS ENEFELLKNK 130 140 150 160 170 180 LKNLANNSTL VMSGSVPAAL GEDAYNEIAN SISNDVKLII DTSGKPLRKI LRLNPFLIKP 190 200 210 220 230 240 NIYELEDLFN AKFDSTKELI KIGKNLVESG VQNIIISMGS DGAIFIGGKN VAFRAFVPKI 250 260 270 280 290 300 NFVSTIGAGD SVIAGFVYAF DNGSTLEDSF KFGVAAGTAT ALKGNLCEFQ DVKKMLCQIR VEDIYTS

References

[1]

"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000783 Genomic DNA. Translation: AAC66983.1.
PIR	E70178.
RefSeq	NP_212764.1. NC_001318.1.
3D structure databases
ProteinModelPortal	O51575.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000008615; EBBORP00000007945; EBBORG00000008614.
GeneID	1195481.
GenomeReviews	Gene locus BB_0630 in contig AE000783_GR.
KEGG	bbu:BB0630.
NMPDR	fig|224326.1.peg.1014.
PATRIC	20557905. VBIBorBur75917_1020.
TIGR	BB_0630.
Phylogenomic databases
GeneTree	EBGT00050000007434.
HOGENOM	HBG670529.
OMA	SVDYIVH.
PhylomeDB	O51575.
ProtClustDB	CLSK507718.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0630-MONOMER.
Family and domain databases
InterPro	IPR022463. 1-phosphofructokinase. IPR011611. Carb/pur_kinase. IPR002173. Carboh/pur_kinase_PfkB_CS. IPR017583. Tagatose/fructose_Pkinase. [Graphical view]
Pfam	PF00294. PfkB. 1 hit. [Graphical view]
PIRSF	PIRSF000535. 1PFK/6PFK/LacC. 1 hit.
TIGRFAMs	TIGR03168. 1-PFK. 1 hit. TIGR03828. PfkB. 1 hit.
PROSITE	PS00583. PFKB_KINASES_1. 1 hit. PS00584. PFKB_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

K1PF_BORBU

Accession

Primary (citable) accession number: O51575

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program