O51567 (ACKA_BORBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase
EC=2.7.2.1

Alternative name(s):
Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	BB_0622

Organism

Borrelia burgdorferi (Lyme disease spirochete)

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.
Sequence caution	The sequence AAC66974.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 405	405	Acetate kinase HAMAP MF_00020		PRO_0000107536

Sequences

	Sequence		Length	Mass (Da)
	O51567 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 0EB43AAA765AFE37	FASTA	405	45,336
	10 20 30 40 50 60 MKILIINTGS SSLKFAIYQY ENSKKIISGI VEKIKSQKSI IKIVNTDGST TERFEKGIEN 70 80 90 100 110 120 HQKAIEKMFK ILTNSDLKIL KTLSEIKIIG HRVVHGGSSL KNSVILNNSI LNKLKQISEL 130 140 150 160 170 180 APLHNPNAIT AIEAVLKILP HAKQVLCFDT SWHQTIKEHA FLYAIPYSWY KNHNIRKYGF 190 200 210 220 230 240 HGLSYSYITK RSSEILNKKI DSLNLIILHL GNGASINAVK NGKSYDTSMG ITPLEGLAMG 250 260 270 280 290 300 TRSGDIDPSI INLMSTILNK TTKQIEEILN KESGILGISE KSNDMRDIWN KIEEGEYQSK 310 320 330 340 350 360 LAVEIMTYRI KKYIGSYIAA LDFNVDAIVF TGGIGVTDYG IRALALKGFE KIGIELDLEK 370 380 390 400 NEMAQSKYLE SEISTINSKL KILAIPTNEE STILEDIYNL IPKNL

References

[1]

"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000783 Genomic DNA. Translation: AAC66974.1. Different initiation.
PIR	E70177.
RefSeq	NP_212756.1. NC_001318.1.
3D structure databases
ProteinModelPortal	O51567.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000008579; EBBORP00000007909; EBBORG00000008578.
GeneID	1195472.
GenomeReviews	Gene locus BB_0622 in contig AE000783_GR.
KEGG	bbu:BB0622.
NMPDR	fig|224326.1.peg.1006.
PATRIC	20557887. VBIBorBur75917_1012.
TIGR	BB_0622.
Phylogenomic databases
GeneTree	EBGT00050000007562.
HOGENOM	HBG285863.
OMA	ERNNIRA.
PhylomeDB	O51567.
ProtClustDB	PRK00180.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0622-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_BORBU

Accession

Primary (citable) accession number: O51567

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	January 25, 2012
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program