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Protein

Acetate kinase

Gene

ackA

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71MagnesiumUniRule annotation
Binding sitei14 – 141ATPUniRule annotation
Binding sitei92 – 921SubstrateUniRule annotation
Active sitei149 – 1491Proton donor/acceptorUniRule annotation
Sitei181 – 1811Transition state stabilizerUniRule annotation
Sitei242 – 2421Transition state stabilizerUniRule annotation
Metal bindingi389 – 3891MagnesiumUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi209 – 2135ATPUniRule annotation
Nucleotide bindingi284 – 2863ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-629-MONOMER.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:BB_0622
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000001807 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Acetate kinasePRO_0000107536Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224326.BB_0622.

Structurei

3D structure databases

ProteinModelPortaliO51567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
KOiK00925.
OMAiHRLKKYI.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiIPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILIINTGS SSLKFAIYQY ENSKKIISGI VEKIKSQKSI IKIVNTDGST
60 70 80 90 100
TERFEKGIEN HQKAIEKMFK ILTNSDLKIL KTLSEIKIIG HRVVHGGSSL
110 120 130 140 150
KNSVILNNSI LNKLKQISEL APLHNPNAIT AIEAVLKILP HAKQVLCFDT
160 170 180 190 200
SWHQTIKEHA FLYAIPYSWY KNHNIRKYGF HGLSYSYITK RSSEILNKKI
210 220 230 240 250
DSLNLIILHL GNGASINAVK NGKSYDTSMG ITPLEGLAMG TRSGDIDPSI
260 270 280 290 300
INLMSTILNK TTKQIEEILN KESGILGISE KSNDMRDIWN KIEEGEYQSK
310 320 330 340 350
LAVEIMTYRI KKYIGSYIAA LDFNVDAIVF TGGIGVTDYG IRALALKGFE
360 370 380 390 400
KIGIELDLEK NEMAQSKYLE SEISTINSKL KILAIPTNEE STILEDIYNL

IPKNL
Length:405
Mass (Da):45,336
Last modified:May 30, 2000 - v2
Checksum:i0EB43AAA765AFE37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66974.2.
PIRiE70177.
RefSeqiNP_212756.2. NC_001318.1.
WP_002665689.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAC66974; AAC66974; BB_0622.
GeneIDi1195472.
KEGGibbu:BB_0622.
PATRICi20557887. VBIBorBur75917_1012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66974.2.
PIRiE70177.
RefSeqiNP_212756.2. NC_001318.1.
WP_002665689.1. NC_001318.1.

3D structure databases

ProteinModelPortaliO51567.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224326.BB_0622.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC66974; AAC66974; BB_0622.
GeneIDi1195472.
KEGGibbu:BB_0622.
PATRICi20557887. VBIBorBur75917_1012.

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
KOiK00925.
OMAiHRLKKYI.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.
BioCyciBBUR224326:G9SO-629-MONOMER.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiIPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACKA_BORBU
AccessioniPrimary (citable) accession number: O51567
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: February 17, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.