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Protein

Lon protease 2

Gene

lon2

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity).By similarity

Catalytic activityi

Hydrolysis of proteins in presence of ATP.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei702 – 7021PROSITE-ProRule annotation
Active sitei745 – 7451PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi352 – 3598ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-618-MONOMER.
BRENDAi3.4.21.53. 902.

Protein family/group databases

MEROPSiS16.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Lon protease 2 (EC:3.4.21.53)
Alternative name(s):
ATP-dependent protease La 2
Gene namesi
Name:lon2
Ordered Locus Names:BB_0613
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000001807 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 796796Lon protease 2PRO_0000076119Add
BLAST

Expressioni

Inductioni

By heat shock.By similarity

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity (By similarity).By similarity

Protein-protein interaction databases

STRINGi224326.BB_0613.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 204196Lon N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini617 – 796180Lon proteolyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S16 family.PROSITE-ProRule annotation
Contains 1 Lon N-terminal domain.PROSITE-ProRule annotation
Contains 1 Lon proteolytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105C6P. Bacteria.
COG0466. LUCA.
KOiK01338.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR003111. LON_substr-bd_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51558-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKNRKEDLP IVILKENVLF PNITLWVTFD NEYVINSIAQ SMLEERLILF
60 70 80 90 100
AYSNEPNCDE SDRGVVKNLC SVGTYSKLIQ VIKISKDVIK VLVECQSRVL
110 120 130 140 150
IDSVSKKNDY LRAKVTFVPD SSGLNRELFT YSKFLKETYE AYRNSLSLKS
160 170 180 190 200
YDADNEPINY FENPSKLVDI IASNSNLENS IKLELLQELN VKTRIEKLIV
210 220 230 240 250
NLSIEIDLLD LKKDINSKVR AKLDKGQRDY FLSEQVKEIQ KRLGKDENDY
260 270 280 290 300
IDRLNSKDIP EDVKSKIEKE ISRLSKMQMN SPDANIIRSY IELILDLPWN
310 320 330 340 350
ENTVMKNHLS EIEFILRNSH YGMDEAKEKI INFLAVYQIN SKVKAPILCL
360 370 380 390 400
VGPPGIGKTS LVESIARSLS REFVKISLGG LRDEAEIRGH RRTYVGSLPG
410 420 430 440 450
VFISAMKRSG KSNPVILLDE IDKINSSYKG NPESALLEVL DPEQNYKFID
460 470 480 490 500
HYLEIPYDLS NVLFVTTANS LNGMSKPLLD RMEIIKVEGY SYIEKLEIAK
510 520 530 540 550
IFLIPSIIKE SFLDKVYIRI EDDVIFNLIR NYTMESGVRG LKRVLTNLIR
560 570 580 590 600
RLVRELLYEY SKDQIIKGNF YSPSSLIHGN NSLFTHDPDI PGIYKIININ
610 620 630 640 650
NYYNYVDTED NLDLIKIDSS GFVYGLAWTN YGGTVLPVEA TKFEKKGDII
660 670 680 690 700
LTGSLGAIMK ESAQLAYSIV KTYSSKLNFD VKESPEIHLH FPEGATPKDG
710 720 730 740 750
PSAGITIATA IASILSDKKV PLDLAMTGEV TLKGFVLPVG GIKEKVLAAY
760 770 780 790
RNGISKVILP KDNKKDYSKL PEEVKDNIDV KFVSSLEEVF DYLNII
Length:796
Mass (Da):90,334
Last modified:April 18, 2012 - v2
Checksum:iC840B8988691A93F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66962.2.
PIRiD70176.
RefSeqiNP_212747.2. NC_001318.1.
WP_002658127.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAC66962; AAC66962; BB_0613.
GeneIDi1195462.
KEGGibbu:BB_0613.
PATRICi20557865. VBIBorBur75917_1003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66962.2.
PIRiD70176.
RefSeqiNP_212747.2. NC_001318.1.
WP_002658127.1. NC_001318.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224326.BB_0613.

Protein family/group databases

MEROPSiS16.009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC66962; AAC66962; BB_0613.
GeneIDi1195462.
KEGGibbu:BB_0613.
PATRICi20557865. VBIBorBur75917_1003.

Phylogenomic databases

eggNOGiENOG4105C6P. Bacteria.
COG0466. LUCA.
KOiK01338.

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-618-MONOMER.
BRENDAi3.4.21.53. 902.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR003111. LON_substr-bd_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry nameiLON2_BORBU
AccessioniPrimary (citable) accession number: O51558
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 18, 2012
Last modified: February 17, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.