Reviewed, UniProtKB/Swiss-Prot O51540 (SYR_BORBU)

Names and origin

Protein names

Recommended name:
    Arginyl-tRNA synthetase
    EC=6.1.1.19
Alternative name(s):
    Arginine--tRNA ligase
      Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	BB_0594

Organism

Borrelia burgdorferi (Lyme disease spirochete) [Complete proteome] [HAMAP]

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	591 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm. HAMAP MF_00123
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 591	591	Arginyl-tRNA synthetase HAMAP MF_00123		PRO_0000151534
Regions
	Motif	133 – 143	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	O51540-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 83B10D702CB0DEBF	FASTA	591	67,637
	10 20 30 40 50 60 MLKRKKMNKS VKKKIKDEIN VIVTNLALSN NIKLDNININ IQKPPKSDLG DISILMFEIG 70 80 90 100 110 120 KTLKLPIEII SEEIIKNLKT KYEIKAVGPY LNIKISRKEY INNTIQMVNT QKDTYGTSKY 130 140 150 160 170 180 LDNKKIILEF SSPNTNKPLH VGHLRNDVIG ESLSRILKAV GAKITKINLI NDRGVHICKS 190 200 210 220 230 240 MLAYKKFGNG ITPEKAFKKG DHLIGDFYVK YNKYSQENEN AEKEIQDLLL LWEQKDVSTI 250 260 270 280 290 300 ELWKKLNKWA IEGIKETYEI TNTSFDKIYL ESEIFKIGKN VVLEGLEKGF CYKREDGAIC 310 320 330 340 350 360 IDLPSDSDEK ADTKVKQKVL IRSNGTSIYL TQDLGNIAVR TKEFNFEEMI YVVGSEQIQH 370 380 390 400 410 420 FKSLFFVAEK LGLSKNKKLI HLSHGMVNLV DGKMKSREGN VIDADNLISN LIELIIPEMT 430 440 450 460 470 480 QKIENKESAK KNALNIALGA IHYYLLKSAI HKDIVFNKKE SLSFTGNSGP YIQYVGARIN 490 500 510 520 530 540 SILEKYKALS IPVMEKIDFE LLKHEKEWEI IKIISELEEN IINAAKDLNP SILTSYSYSL 550 560 570 580 590 AKHFSTYYQE VKVIDTNNIN LTAARIEFLK AILQTIKNCM YLLNIPYMLK M

References

[1]

"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000783 Genomic DNA. Translation: AAC66956.1.
PIR	A70174.
RefSeq	NP_212728.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1195441.
GenomeReviews	Gene locus BB_0594 in contig AE000783_GR.
KEGG	bbu:BB0594.
NMPDR	fig|224326.1.peg.978.
TIGR	BB_0594.
Phylogenomic databases
HOGENOM	O51540.
OMA	GKLITAY.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0594-MON.
BRENDA	6.1.1.19. 142596.
Family and domain databases
HAMAP	MF_00123. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ic. IPR015945. Arg-tRNA-synth_Ic_core. IPR005148. Arg-tRNA-synth_Ic_N. IPR008909. DALR_anticod_bd. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_BORBU

Accession

Primary (citable) accession number: O51540

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	November 3, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)