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O51540 (SYR_BORBU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:BB_0594
OrganismBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) [Reference proteome] [HAMAP]
Taxonomic identifier224326 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group

Protein attributes

Sequence length585 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 585585Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151534

Regions

Motif127 – 13711"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
O51540 [UniParc].

Last modified April 18, 2012. Version 2.
Checksum: B3E59137BDE34656

FASTA58566,852
        10         20         30         40         50         60 
MNKSVKKKIK DEINVIVTNL ALSNNIKLDN ININIQKPPK SDLGDISILM FEIGKTLKLP 

        70         80         90        100        110        120 
IEIISEEIIK NLKTKYEIKA VGPYLNIKIS RKEYINNTIQ MVNTQKDTYG TSKYLDNKKI 

       130        140        150        160        170        180 
ILEFSSPNTN KPLHVGHLRN DVIGESLSRI LKAVGAKITK INLINDRGVH ICKSMLAYKK 

       190        200        210        220        230        240 
FGNGITPEKA FKKGDHLIGD FYVKYNKYSQ ENENAEKEIQ DLLLLWEQKD VSTIELWKKL 

       250        260        270        280        290        300 
NKWAIEGIKE TYEITNTSFD KIYLESEIFK IGKNVVLEGL EKGFCYKRED GAICIDLPSD 

       310        320        330        340        350        360 
SDEKADTKVK QKVLIRSNGT SIYLTQDLGN IAVRTKEFNF EEMIYVVGSE QIQHFKSLFF 

       370        380        390        400        410        420 
VAEKLGLSKN KKLIHLSHGM VNLVDGKMKS REGNVIDADN LISNLIELII PEMTQKIENK 

       430        440        450        460        470        480 
ESAKKNALNI ALGAIHYYLL KSAIHKDIVF NKKESLSFTG NSGPYIQYVG ARINSILEKY 

       490        500        510        520        530        540 
KALSIPVMEK IDFELLKHEK EWEIIKIISE LEENIINAAK DLNPSILTSY SYSLAKHFST 

       550        560        570        580 
YYQEVKVIDT NNINLTAARI EFLKAILQTI KNCMYLLNIP YMLKM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000783 Genomic DNA. Translation: AAC66956.2.
PIRA70174.
RefSeqNP_212728.2. NC_001318.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224326.BB0594.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC66956; AAC66956; BB_0594.
GeneID1195441.
KEGGbbu:BB_0594.
PATRIC20557821. VBIBorBur75917_0985.

Phylogenomic databases

eggNOGCOG0018.
KOK01887.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycBBUR224326:G9SO-596-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_BORBU
AccessionPrimary (citable) accession number: O51540
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 18, 2012
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries