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Protein

DNA polymerase I

Gene

polA

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:BB_0548
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000001807 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012361 – 908DNA polymerase IAdd BLAST908

Proteomic databases

PRIDEiO51498

Interactioni

Protein-protein interaction databases

STRINGi224326.BB_0548

Structurei

3D structure databases

ProteinModelPortaliO51498
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 3185'-3' exonucleaseAdd BLAST318
Domaini319 – 5313'-5' exonucleaseAdd BLAST213

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni532 – 908PolymeraseAdd BLAST377

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

eggNOGiENOG4105C2M Bacteria
COG0258 LUCA
COG0749 LUCA
KOiK02335
OMAiETGRVHT

Family and domain databases

CDDicd09898 H3TH_53EXO, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR002562 3'-5'_exonuclease_dom
IPR020046 5-3_exonucl_a-hlix_arch_N
IPR036279 5-3_exonuclease_C_sf
IPR002421 5-3_exonuclease_N
IPR019760 DNA-dir_DNA_pol_A_CS
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR020045 DNA_polI_H3TH
IPR018320 DNA_polymerase_1
IPR002298 DNA_polymerase_A
IPR008918 HhH2
IPR029060 PIN-like_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10133 PTHR10133, 1 hit
PfamiView protein in Pfam
PF01367 5_3_exonuc, 1 hit
PF02739 5_3_exonuc_N, 1 hit
PF00476 DNA_pol_A, 1 hit
PF01612 DNA_pol_A_exo1, 1 hit
PRINTSiPR00868 DNAPOLI
SMARTiView protein in SMART
SM00474 35EXOc, 1 hit
SM00475 53EXOc, 1 hit
SM00279 HhH2, 1 hit
SM00482 POLAc, 1 hit
SUPFAMiSSF47807 SSF47807, 1 hit
SSF53098 SSF53098, 1 hit
SSF88723 SSF88723, 1 hit
TIGRFAMsiTIGR00593 pola, 1 hit
PROSITEiView protein in PROSITE
PS00447 DNA_POLYMERASE_A, 1 hit

Sequencei

Sequence statusi: Complete.

O51498-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKELYLIDAL NIIFRNYHVM KNYPLLNTQG ENVNAFIGFF KTLFFIIKEK
60 70 80 90 100
NPEHLIITFD SEVPTFRKQK YPSYKATRDL PPDDLIPQIG WIKEGLLKAK
110 120 130 140 150
IPIFEMEGYE ADDLLASFAK KAAKNNYLTY IISPDKDLLQ TMSEYVKILK
160 170 180 190 200
IENNSFIEMD NEYVTKKFGV NSFQIKDYLA IVGDRSDNIP GIKGIGAKGA
210 220 230 240 250
ANLLREFKTL DGIYSNLEII NKKHRELLIK EKENAFLSYE LVSLEENLKI
260 270 280 290 300
PEIENFALKN FSEEIISLFE KHSAIALIKT YKKDILKQEK ENADQKSLFK
310 320 330 340 350
QEPTTNSLDD INTIDTENVK YRSITTKIEL DDLIESLKKA KYISIDTETS
360 370 380 390 400
SLDTYTAKLI GISISFKEFE GYYIPIEAKG KIYIEKNYII QKFNNLFESN
410 420 430 440 450
PKIIGQNYKF DYKILKNNGF NPIPPYFDTM IAAYLIDTNS KVSLDFLAEK
460 470 480 490 500
YLMHKNIKYE DVIQKNDNFA NISLEMATSY SSEDADITFR LFNIFTKKLK
510 520 530 540 550
EDKLDKLMHE IEMPFNKVII EMEENGIYLD KEYLKEYGKE LGKELEAIEN
560 570 580 590 600
EIIKSIGIDF NLNSPKQMHE ILFEKLNLKL PEKMKKDSTD IKVLESLREQ
610 620 630 640 650
HESIENLIKY RQIAKLKSTY TDNLIELINY KTNRLHTSFI QTKTATGRIT
660 670 680 690 700
SINPNLQNIP IKDEKGRKIR KAFKPENGNI FISADYSQIE LAILAHLSQD
710 720 730 740 750
EVLIKAFENN KDIHTETASK LFKIEEKEIT PNLRRIAKSI NFGIIYRMSD
760 770 780 790 800
FRLAKELGIT KEEAKGFINS YFDSYPKIKE FIINQINFVR NAGYSETILK
810 820 830 840 850
RRRYIKEINS NNYLERSAAE RIAINSIIQG SAADIMKIAM VKVFNEFKSK
860 870 880 890 900
KMESKILLQV HDEMLIESPI EEENEVKKIL KIMMETAYTL NLPLRANIET

GKSWGEIH
Length:908
Mass (Da):105,504
Last modified:June 1, 1998 - v1
Checksum:iB58512AEB0DCBD94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA Translation: AAC66909.1
PIRiC70168
RefSeqiNP_212682.1, NC_001318.1
WP_010889763.1, NC_001318.1

Genome annotation databases

EnsemblBacteriaiAAC66909; AAC66909; BB_0548
GeneIDi1195395
KEGGibbu:BB_0548
PATRICifig|224326.49.peg.939

Similar proteinsi

Entry informationi

Entry nameiDPO1_BORBU
AccessioniPrimary (citable) accession number: O51498
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health