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Protein

DNA polymerase I

Gene

polA

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity.By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-549-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:BB_0548
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000001807 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 908908DNA polymerase IPRO_0000101236Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224326.BB_0548.

Structurei

3D structure databases

ProteinModelPortaliO51498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 3183185'-3' exonucleaseAdd
BLAST
Domaini319 – 5312133'-5' exonucleaseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni532 – 908377PolymeraseAdd
BLAST

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated
Contains 1 3'-5' exonuclease domain.Curated
Contains 1 5'-3' exonuclease domain.Curated

Phylogenomic databases

eggNOGiENOG4105C2M. Bacteria.
COG0258. LUCA.
COG0749. LUCA.
KOiK02335.
OMAiCFDTETT.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
PF01612. DNA_pol_A_exo1. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51498-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKELYLIDAL NIIFRNYHVM KNYPLLNTQG ENVNAFIGFF KTLFFIIKEK
60 70 80 90 100
NPEHLIITFD SEVPTFRKQK YPSYKATRDL PPDDLIPQIG WIKEGLLKAK
110 120 130 140 150
IPIFEMEGYE ADDLLASFAK KAAKNNYLTY IISPDKDLLQ TMSEYVKILK
160 170 180 190 200
IENNSFIEMD NEYVTKKFGV NSFQIKDYLA IVGDRSDNIP GIKGIGAKGA
210 220 230 240 250
ANLLREFKTL DGIYSNLEII NKKHRELLIK EKENAFLSYE LVSLEENLKI
260 270 280 290 300
PEIENFALKN FSEEIISLFE KHSAIALIKT YKKDILKQEK ENADQKSLFK
310 320 330 340 350
QEPTTNSLDD INTIDTENVK YRSITTKIEL DDLIESLKKA KYISIDTETS
360 370 380 390 400
SLDTYTAKLI GISISFKEFE GYYIPIEAKG KIYIEKNYII QKFNNLFESN
410 420 430 440 450
PKIIGQNYKF DYKILKNNGF NPIPPYFDTM IAAYLIDTNS KVSLDFLAEK
460 470 480 490 500
YLMHKNIKYE DVIQKNDNFA NISLEMATSY SSEDADITFR LFNIFTKKLK
510 520 530 540 550
EDKLDKLMHE IEMPFNKVII EMEENGIYLD KEYLKEYGKE LGKELEAIEN
560 570 580 590 600
EIIKSIGIDF NLNSPKQMHE ILFEKLNLKL PEKMKKDSTD IKVLESLREQ
610 620 630 640 650
HESIENLIKY RQIAKLKSTY TDNLIELINY KTNRLHTSFI QTKTATGRIT
660 670 680 690 700
SINPNLQNIP IKDEKGRKIR KAFKPENGNI FISADYSQIE LAILAHLSQD
710 720 730 740 750
EVLIKAFENN KDIHTETASK LFKIEEKEIT PNLRRIAKSI NFGIIYRMSD
760 770 780 790 800
FRLAKELGIT KEEAKGFINS YFDSYPKIKE FIINQINFVR NAGYSETILK
810 820 830 840 850
RRRYIKEINS NNYLERSAAE RIAINSIIQG SAADIMKIAM VKVFNEFKSK
860 870 880 890 900
KMESKILLQV HDEMLIESPI EEENEVKKIL KIMMETAYTL NLPLRANIET

GKSWGEIH
Length:908
Mass (Da):105,504
Last modified:June 1, 1998 - v1
Checksum:iB58512AEB0DCBD94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66909.1.
PIRiC70168.
RefSeqiNP_212682.1. NC_001318.1.
WP_010889763.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAC66909; AAC66909; BB_0548.
GeneIDi1195395.
KEGGibbu:BB_0548.
PATRICi20557727. VBIBorBur75917_0939.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66909.1.
PIRiC70168.
RefSeqiNP_212682.1. NC_001318.1.
WP_010889763.1. NC_001318.1.

3D structure databases

ProteinModelPortaliO51498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224326.BB_0548.

Protocols and materials databases

DNASUi1195395.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC66909; AAC66909; BB_0548.
GeneIDi1195395.
KEGGibbu:BB_0548.
PATRICi20557727. VBIBorBur75917_0939.

Phylogenomic databases

eggNOGiENOG4105C2M. Bacteria.
COG0258. LUCA.
COG0749. LUCA.
KOiK02335.
OMAiCFDTETT.

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-549-MONOMER.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
PF01612. DNA_pol_A_exo1. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPO1_BORBU
AccessioniPrimary (citable) accession number: O51498
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.