Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).By similarity

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11ATPBy similarity1
Binding sitei92ATPBy similarity1
Binding sitei98ATPBy similarity1
Binding sitei109ATPBy similarity1
Binding sitei129ATPBy similarity1
Active sitei132Pros-phosphohistidine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase (EC:2.7.4.6)
Short name:
NDK
Short name:
NDP kinase
Alternative name(s):
Nucleoside-2-P kinase
Gene namesi
Name:ndk
Ordered Locus Names:BB_0463
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000001807 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001369511 – 167Nucleoside diphosphate kinaseAdd BLAST167

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO51419.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi224326.BB_0463.

Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 10Combined sources8
Helixi12 – 16Combined sources5
Helixi20 – 30Combined sources11
Beta strandi33 – 41Combined sources9
Helixi44 – 50Combined sources7
Helixi53 – 59Combined sources7
Helixi62 – 72Combined sources11
Beta strandi75 – 85Combined sources11
Helixi87 – 95Combined sources9
Helixi100 – 102Combined sources3
Helixi108 – 112Combined sources5
Helixi117 – 123Combined sources7
Beta strandi130 – 133Combined sources4
Helixi137 – 147Combined sources11
Helixi150 – 152Combined sources3
Helixi161 – 164Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DI6X-ray2.40A/B/C/D/E/F1-167[»]
4DZ6X-ray2.20A/B/C/D/E/F1-167[»]
ProteinModelPortaliO51419.
SMRiO51419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiENOG4108UGX. Bacteria.
COG0105. LUCA.
KOiK00940.
OMAiWFHSSEL.

Family and domain databases

InterProiIPR001564. Nucleoside_diP_kinase.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51419-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLQKTLCIV KPDGVRRGLI GDVVSRFERV GLKMVAAKML IVDESLAKKH
60 70 80 90 100
YLYDDIVFRH SEAVWNSLIK FISNSPVFTF VVEGVESIEV VRKLCGATEP
110 120 130 140 150
KLAIPGTIRG DFSYHSFKYS NEKGFSIYNV IHASANEADA MREIPIWFKD
160
NEILNYKRDD ECEHYYC
Length:167
Mass (Da):19,159
Last modified:September 26, 2001 - v2
Checksum:i4A8E142C253182B8
GO

Sequence cautioni

The sequence AAC66829 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66829.1. Different initiation.
PIRiF70157.
RefSeqiNP_212597.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAC66829; AAC66829; BB_0463.
GeneIDi1195309.
KEGGibbu:BB_0463.
PATRICi20557554. VBIBorBur75917_0856.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66829.1. Different initiation.
PIRiF70157.
RefSeqiNP_212597.1. NC_001318.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DI6X-ray2.40A/B/C/D/E/F1-167[»]
4DZ6X-ray2.20A/B/C/D/E/F1-167[»]
ProteinModelPortaliO51419.
SMRiO51419.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224326.BB_0463.

Proteomic databases

PRIDEiO51419.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC66829; AAC66829; BB_0463.
GeneIDi1195309.
KEGGibbu:BB_0463.
PATRICi20557554. VBIBorBur75917_0856.

Phylogenomic databases

eggNOGiENOG4108UGX. Bacteria.
COG0105. LUCA.
KOiK00940.
OMAiWFHSSEL.

Family and domain databases

InterProiIPR001564. Nucleoside_diP_kinase.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDK_BORBU
AccessioniPrimary (citable) accession number: O51419
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.