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O51401

- ALF_BORBU

UniProt

O51401 - ALF_BORBU

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Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611Glyceraldehyde 3-phosphateBy similarity
Active sitei109 – 1091Proton donorBy similarity
Metal bindingi110 – 1101Zinc 1; catalyticBy similarity
Metal bindingi144 – 1441Zinc 2By similarity
Metal bindingi174 – 1741Zinc 2By similarity
Metal bindingi226 – 2261Zinc 1; catalyticBy similarity
Binding sitei227 – 2271Dihydroxyacetone phosphate; via amide nitrogenBy similarity
Metal bindingi265 – 2651Zinc 1; catalyticBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-446-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Ordered Locus Names:BB_0445
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Fructose-bisphosphate aldolasePRO_0000178707Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224326.BB0445.

Structurei

3D structure databases

ProteinModelPortaliO51401.
SMRiO51401. Positions 3-357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni266 – 2683Dihydroxyacetone phosphate bindingBy similarity
Regioni287 – 2904Dihydroxyacetone phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
KOiK01624.
OMAiHNSLDFV.
OrthoDBiEOG69GZPB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51401-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGVLDKIKPG VVYGKELHFL YEICKKEGFA IPSINCIGTN SINAVLEAAK
60 70 80 90 100
EINSPIMIQF SNSGSAFISG KGLKMEKPQG VSIVGAISGA MHVHLMAEHY
110 120 130 140 150
GVPVVLHTDH CAKNLLPWVE GLLEYGEKYY SQHKKPLFSS HMLDLSEEPI
160 170 180 190 200
KENIEISKKF LERMAKIEMF LEIELGITGG EEDGVDNSDR ALHELFSTPE
210 220 230 240 250
DIYYGYSELL KVSPNFQIAA AFGNVHGVYK PGNVKLTPKV LKDGQDYVIS
260 270 280 290 300
KTGVNMAKPV SYVFHGGSGS TIDEINEALS YGVVKMNIDT DTQWAAWEGV
310 320 330 340 350
LNYYKKNESR LQGQLGDGKD IDIPNKKFYD PRVWLREAEV SMKDRVKIAC

KNLNNINRN
Length:359
Mass (Da):39,981
Last modified:June 1, 1998 - v1
Checksum:iFAF4209478692FCB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21G → S AA sequence (PubMed:2738156)Curated
Sequence conflicti6 – 61K → L AA sequence (PubMed:2738156)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000783 Genomic DNA. Translation: AAB91507.1.
PIRiD70155.
RefSeqiNP_212579.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAB91507; AAB91507; BB_0445.
GeneIDi1195290.
KEGGibbu:BB_0445.
PATRICi20557506. VBIBorBur75917_0836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000783 Genomic DNA. Translation: AAB91507.1 .
PIRi D70155.
RefSeqi NP_212579.1. NC_001318.1.

3D structure databases

ProteinModelPortali O51401.
SMRi O51401. Positions 3-357.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224326.BB0445.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB91507 ; AAB91507 ; BB_0445 .
GeneIDi 1195290.
KEGGi bbu:BB_0445.
PATRICi 20557506. VBIBorBur75917_0836.

Phylogenomic databases

eggNOGi COG0191.
KOi K01624.
OMAi HNSLDFV.
OrthoDBi EOG69GZPB.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
BioCyci BBUR224326:G9SO-446-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  2. "Identification and characterization of an endoflagellar antigen of Borrelia burgdorferi."
    Coleman J.L., Benach J.L.
    J. Clin. Invest. 84:322-330(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-11.
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry nameiALF_BORBU
AccessioniPrimary (citable) accession number: O51401
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: October 1, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3