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Protein

Glycine--tRNA ligase

Gene

glyQS

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the attachment of glycine to tRNA(Gly).UniRule annotation

Catalytic activityi

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei97SubstrateUniRule annotation1
Binding sitei145SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi177 – 179ATPUniRule annotation3
Nucleotide bindingi187 – 192ATPUniRule annotation6
Nucleotide bindingi262 – 263ATPUniRule annotation2
Nucleotide bindingi308 – 311ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine--tRNA ligaseUniRule annotation (EC:6.1.1.14UniRule annotation)
Alternative name(s):
Glycyl-tRNA synthetaseUniRule annotation
Short name:
GlyRSUniRule annotation
Gene namesi
Name:glyQSUniRule annotation
Synonyms:glyS
Ordered Locus Names:BB_0371
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000001807 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000729491 – 445Glycine--tRNA ligaseAdd BLAST445

Proteomic databases

PRIDEiO51344.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi224326.BB_0371.

Structurei

3D structure databases

ProteinModelPortaliO51344.
SMRiO51344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni192 – 196Substrate bindingUniRule annotation5
Regioni304 – 308Substrate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9H. Bacteria.
COG0423. LUCA.
KOiK01880.
OMAiMGWSELE.

Family and domain databases

CDDicd00774. GlyRS-like_core. 1 hit.
Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00253_B. Gly_tRNA_synth_B. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR027031. Gly-tRNA_synthase/POLG2.
IPR022961. Gly_tRNA_ligase_bac.
IPR033731. GlyRS-like_core.
IPR002315. tRNA-synt_gly.
[Graphical view]
PANTHERiPTHR10745. PTHR10745. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSiPR01043. TRNASYNTHGLY.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00389. glyS_dimeric. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51344-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRMEDIISL AKRKGFVFQS SEVYGGLSGA WDYGPLGVEL KKNIKKEWWK
60 70 80 90 100
SMVYLHENIV GLDSAIFMRP EIWRASGHVD GFSDSMVDCK DCKSRFRADF
110 120 130 140 150
IDLSKNCPNC KVGNNFTSPR SFNLMFKTHI GVVEDSSSEV YLRPETAQGI
160 170 180 190 200
FVNFRNVLDS SRLKIPFGIA QVGKAFRNEI VTKNFIFRTC EFEQMEMQFF
210 220 230 240 250
VHPKQIDEWF CYWQQNRMNF FIETLKISPD RLRFKAHDST QLAHYAKAAF
260 270 280 290 300
DIEYEFPFGF QEVEGIHNRG NYDLTQHAKF SNKPKVFEYH DLLTKEKYVP
310 320 330 340 350
YVIETSAGLT RSVLMTLCDA YSEEELSDGD KRIVLRLHPK LAPYKIAIFP
360 370 380 390 400
LVKKVELTEI ARRIYMELCD DFHIFYDDSG TIGKRYRRQD EIGTPYCVTI
410 420 430 440
DYNTIEDETV TVRERNSMTQ KRIFINDLYS YIKTEILNYK EDFNK
Length:445
Mass (Da):52,210
Last modified:June 1, 1998 - v1
Checksum:i802348D2F089C4B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66743.1.
PIRiB70146.
RefSeqiNP_212505.1. NC_001318.1.
WP_002656113.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAC66743; AAC66743; BB_0371.
GeneIDi1195208.
KEGGibbu:BB_0371.
PATRICi20557352. VBIBorBur75917_0766.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66743.1.
PIRiB70146.
RefSeqiNP_212505.1. NC_001318.1.
WP_002656113.1. NC_001318.1.

3D structure databases

ProteinModelPortaliO51344.
SMRiO51344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224326.BB_0371.

Proteomic databases

PRIDEiO51344.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC66743; AAC66743; BB_0371.
GeneIDi1195208.
KEGGibbu:BB_0371.
PATRICi20557352. VBIBorBur75917_0766.

Phylogenomic databases

eggNOGiENOG4105D9H. Bacteria.
COG0423. LUCA.
KOiK01880.
OMAiMGWSELE.

Family and domain databases

CDDicd00774. GlyRS-like_core. 1 hit.
Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00253_B. Gly_tRNA_synth_B. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR027031. Gly-tRNA_synthase/POLG2.
IPR022961. Gly_tRNA_ligase_bac.
IPR033731. GlyRS-like_core.
IPR002315. tRNA-synt_gly.
[Graphical view]
PANTHERiPTHR10745. PTHR10745. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSiPR01043. TRNASYNTHGLY.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00389. glyS_dimeric. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYG_BORBU
AccessioniPrimary (citable) accession number: O51344
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.