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Protein

Tyrosine--tRNA ligase

Gene

tyrS

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).UniRule annotation

Catalytic activityi

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35TyrosineUniRule annotation1
Binding sitei166TyrosineUniRule annotation1
Binding sitei170TyrosineUniRule annotation1
Binding sitei229ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine--tRNA ligaseUniRule annotation (EC:6.1.1.1UniRule annotation)
Alternative name(s):
Tyrosyl-tRNA synthetaseUniRule annotation
Short name:
TyrRSUniRule annotation
Gene namesi
Name:tyrSUniRule annotation
Ordered Locus Names:BB_0370
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000001807 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000556451 – 405Tyrosine--tRNA ligaseAdd BLAST405

Proteomic databases

PRIDEiO51343

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224326.BB_0370

Structurei

3D structure databases

ProteinModelPortaliO51343
SMRiO51343
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini340 – 405S4 RNA-bindingUniRule annotationAdd BLAST66

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 49"HIGH" region10
Motifi226 – 230"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DA0 Bacteria
COG0162 LUCA
KOiK01866
OMAiVNYMMAK

Family and domain databases

CDDicd00165 S4, 1 hit
cd00805 TyrRS_core, 1 hit
Gene3Di3.10.290.10, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_02006 Tyr_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002942 S4_RNA-bd
IPR036986 S4_RNA-bd_sf
IPR002307 Tyr-tRNA-ligase
IPR024088 Tyr-tRNA-ligase_bac-type
IPR024107 Tyr-tRNA-ligase_bac_1
PANTHERiPTHR11766 PTHR11766, 1 hit
PfamiView protein in Pfam
PF01479 S4, 1 hit
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01040 TRNASYNTHTYR
SMARTiView protein in SMART
SM00363 S4, 1 hit
TIGRFAMsiTIGR00234 tyrS, 1 hit
PROSITEiView protein in PROSITE
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

O51343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLALSLLHK RGFLKQCTSL KVLSDLMDRE KIVFYAGVDA TSSSLHIGHL
60 70 80 90 100
IPFLAMMHLR QHGHMPIVLI GDSTAKIGDP SGKSEMRKIL SSEEIGNNAL
110 120 130 140 150
LIKNQLQRIT KFTSECFIHN SNWLDNLNYI EFLRDVGMHF SVNRMLSFET
160 170 180 190 200
YKRRMDFGLS FIEFNYQLLQ SYDYYMLNKI KNCRLQIGGD DQWGNIISGV
210 220 230 240 250
DLIRKKNGSE TFGLTFPLIT RSDGKKMGKS EKGAVYLDSN LFSIYDFYQY
260 270 280 290 300
FRNTSDSDVK TFLYLFTFLE EDEIELISNF KGNSLNKAKE ILAFEITKIV
310 320 330 340 350
HGEAEALKVQ EASFAAFRGS GDRSNIPFFK FSFSSLKEEI LLVDLMLDSK
360 370 380 390 400
IVPSKSEGRR LIDSGGVYIN GKRVESQSHL LTKKDFNNNE VELRVGKKKF

LRIVI
Length:405
Mass (Da):46,363
Last modified:June 1, 1998 - v1
Checksum:iF6DED7B6F1F2EBBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA Translation: AAC66744.1
PIRiA70146
RefSeqiNP_212504.1, NC_001318.1
WP_002656396.1, NC_001318.1

Genome annotation databases

EnsemblBacteriaiAAC66744; AAC66744; BB_0370
GeneIDi1195207
KEGGibbu:BB_0370
PATRICifig|224326.49.peg.765

Similar proteinsi

Entry informationi

Entry nameiSYY_BORBU
AccessioniPrimary (citable) accession number: O51343
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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