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O51323

- KPYK_BORBU

UniProt

O51323 - KPYK_BORBU

Protein

Pyruvate kinase

Gene

pyk

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.
    Potassium.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341SubstrateBy similarity
    Metal bindingi36 – 361PotassiumBy similarity
    Metal bindingi64 – 641PotassiumBy similarity
    Metal bindingi65 – 651Potassium; via carbonyl oxygenBy similarity
    Sitei214 – 2141Transition state stabilizerBy similarity
    Metal bindingi216 – 2161MagnesiumBy similarity
    Binding sitei239 – 2391Substrate; via amide nitrogenBy similarity
    Metal bindingi240 – 2401MagnesiumBy similarity
    Binding sitei240 – 2401Substrate; via amide nitrogenBy similarity
    Binding sitei272 – 2721SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

    Enzyme and pathway databases

    BioCyciBBUR224326:G9SO-346-MONOMER.
    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase (EC:2.7.1.40)
    Short name:
    PK
    Gene namesi
    Name:pyk
    Ordered Locus Names:BB_0348
    OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
    Taxonomic identifieri224326 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
    ProteomesiUP000001807: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477Pyruvate kinasePRO_0000112057Add
    BLAST

    Proteomic databases

    PRIDEiO51323.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi224326.BB0348.

    Structurei

    3D structure databases

    ProteinModelPortaliO51323.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0469.
    KOiK00873.
    OMAiGTHEEHK.
    OrthoDBiEOG6GBMB0.

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProiIPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
    PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O51323-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISKLTKIVA TISDLRCEPE HIKDLHDAGV NVIRLNTAHQ SHEDTIKVID    50
    NVRKISNKIA LMIDTKGPEV RTANIENPII VKTGDKVIIS TSPINEPNNF 100
    QTNYDGFVKE VPQGSKVLID DGELEMTVVA KLPDRLICEI KNDGQIKNKK 150
    SINTPGISLK LQSVTEKDKG FIELAAKYNV DFIAHSFVRH SKDVQDVQEI 200
    LTASGNPDVK IISKIENQEG IDNIEEIAKA SYGIMVARGD MGVEIPAEDV 250
    PIAQLKITQT CIKYGIPVIT ATQMLHTMIE NPRPTRAEVS DIANAILNGT 300
    DAIMLSGETA YGKYPIEAVK MMTSIAKKVE KHRKMTLYKD ELFYDKSITR 350
    NYIIKCAIDA TKLMDIKAII VDSLKGKTAR IMATYRASVP LFITTNSERL 400
    ARELALSYGV YSNLVDNNFK RTTEFVVTSL KMLKEQGVVN DKDTVIIISG 450
    NPNRNIEKGT EFMEINTVED AIKGRNI 477
    Length:477
    Mass (Da):53,032
    Last modified:June 1, 1998 - v1
    Checksum:i40D3CCAC9ACB7D98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000783 Genomic DNA. Translation: AAC66733.1.
    PIRiC70143.
    RefSeqiNP_212482.1. NC_001318.1.

    Genome annotation databases

    EnsemblBacteriaiAAC66733; AAC66733; BB_0348.
    GeneIDi1195185.
    KEGGibbu:BB_0348.
    PATRICi20557308. VBIBorBur75917_0744.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000783 Genomic DNA. Translation: AAC66733.1 .
    PIRi C70143.
    RefSeqi NP_212482.1. NC_001318.1.

    3D structure databases

    ProteinModelPortali O51323.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224326.BB0348.

    Proteomic databases

    PRIDEi O51323.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC66733 ; AAC66733 ; BB_0348 .
    GeneIDi 1195185.
    KEGGi bbu:BB_0348.
    PATRICi 20557308. VBIBorBur75917_0744.

    Phylogenomic databases

    eggNOGi COG0469.
    KOi K00873.
    OMAi GTHEEHK.
    OrthoDBi EOG6GBMB0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .
    BioCyci BBUR224326:G9SO-346-MONOMER.

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProi IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

    Entry informationi

    Entry nameiKPYK_BORBU
    AccessioniPrimary (citable) accession number: O51323
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3