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O51323 (KPYK_BORBU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase

Short name=PK
EC=2.7.1.40
Gene names
Name:pyk
Ordered Locus Names:BB_0348
OrganismBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) [Reference proteome] [HAMAP]
Taxonomic identifier224326 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group

Protein attributes

Sequence length477 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium.

Potassium.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 477477Pyruvate kinase
PRO_0000112057

Sites

Metal binding361Potassium By similarity
Metal binding641Potassium By similarity
Metal binding651Potassium; via carbonyl oxygen By similarity
Metal binding2161Magnesium By similarity
Metal binding2401Magnesium By similarity
Binding site341Substrate By similarity
Binding site2391Substrate; via amide nitrogen By similarity
Binding site2401Substrate; via amide nitrogen By similarity
Binding site2721Substrate By similarity
Site2141Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
O51323 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 40D3CCAC9ACB7D98

FASTA47753,032
        10         20         30         40         50         60 
MISKLTKIVA TISDLRCEPE HIKDLHDAGV NVIRLNTAHQ SHEDTIKVID NVRKISNKIA 

        70         80         90        100        110        120 
LMIDTKGPEV RTANIENPII VKTGDKVIIS TSPINEPNNF QTNYDGFVKE VPQGSKVLID 

       130        140        150        160        170        180 
DGELEMTVVA KLPDRLICEI KNDGQIKNKK SINTPGISLK LQSVTEKDKG FIELAAKYNV 

       190        200        210        220        230        240 
DFIAHSFVRH SKDVQDVQEI LTASGNPDVK IISKIENQEG IDNIEEIAKA SYGIMVARGD 

       250        260        270        280        290        300 
MGVEIPAEDV PIAQLKITQT CIKYGIPVIT ATQMLHTMIE NPRPTRAEVS DIANAILNGT 

       310        320        330        340        350        360 
DAIMLSGETA YGKYPIEAVK MMTSIAKKVE KHRKMTLYKD ELFYDKSITR NYIIKCAIDA 

       370        380        390        400        410        420 
TKLMDIKAII VDSLKGKTAR IMATYRASVP LFITTNSERL ARELALSYGV YSNLVDNNFK 

       430        440        450        460        470 
RTTEFVVTSL KMLKEQGVVN DKDTVIIISG NPNRNIEKGT EFMEINTVED AIKGRNI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000783 Genomic DNA. Translation: AAC66733.1.
PIRC70143.
RefSeqNP_212482.1. NC_001318.1.

3D structure databases

ProteinModelPortalO51323.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224326.BB0348.

Proteomic databases

PRIDEO51323.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC66733; AAC66733; BB_0348.
GeneID1195185.
KEGGbbu:BB_0348.
PATRIC20557308. VBIBorBur75917_0744.

Phylogenomic databases

eggNOGCOG0469.
KOK00873.
OMANNKGVNF.
OrthoDBEOG6GBMB0.
ProtClustDBPRK05826.

Enzyme and pathway databases

BioCycBBUR224326:G9SO-346-MONOMER.
UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK_BORBU
AccessionPrimary (citable) accession number: O51323
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: November 13, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways