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O51323

- KPYK_BORBU

UniProt

O51323 - KPYK_BORBU

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Protein

Pyruvate kinase

Gene

pyk

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Protein has several cofactor binding sites:

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341SubstrateBy similarity
Metal bindingi36 – 361PotassiumBy similarity
Metal bindingi64 – 641PotassiumBy similarity
Metal bindingi65 – 651Potassium; via carbonyl oxygenBy similarity
Sitei214 – 2141Transition state stabilizerBy similarity
Metal bindingi216 – 2161MagnesiumBy similarity
Binding sitei239 – 2391Substrate; via amide nitrogenBy similarity
Metal bindingi240 – 2401MagnesiumBy similarity
Binding sitei240 – 2401Substrate; via amide nitrogenBy similarity
Binding sitei272 – 2721SubstrateBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-346-MONOMER.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:pyk
Ordered Locus Names:BB_0348
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Pyruvate kinasePRO_0000112057Add
BLAST

Proteomic databases

PRIDEiO51323.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi224326.BB0348.

Structurei

3D structure databases

ProteinModelPortaliO51323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0469.
KOiK00873.
OMAiGTHEEHK.
OrthoDBiEOG6GBMB0.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51323-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISKLTKIVA TISDLRCEPE HIKDLHDAGV NVIRLNTAHQ SHEDTIKVID
60 70 80 90 100
NVRKISNKIA LMIDTKGPEV RTANIENPII VKTGDKVIIS TSPINEPNNF
110 120 130 140 150
QTNYDGFVKE VPQGSKVLID DGELEMTVVA KLPDRLICEI KNDGQIKNKK
160 170 180 190 200
SINTPGISLK LQSVTEKDKG FIELAAKYNV DFIAHSFVRH SKDVQDVQEI
210 220 230 240 250
LTASGNPDVK IISKIENQEG IDNIEEIAKA SYGIMVARGD MGVEIPAEDV
260 270 280 290 300
PIAQLKITQT CIKYGIPVIT ATQMLHTMIE NPRPTRAEVS DIANAILNGT
310 320 330 340 350
DAIMLSGETA YGKYPIEAVK MMTSIAKKVE KHRKMTLYKD ELFYDKSITR
360 370 380 390 400
NYIIKCAIDA TKLMDIKAII VDSLKGKTAR IMATYRASVP LFITTNSERL
410 420 430 440 450
ARELALSYGV YSNLVDNNFK RTTEFVVTSL KMLKEQGVVN DKDTVIIISG
460 470
NPNRNIEKGT EFMEINTVED AIKGRNI
Length:477
Mass (Da):53,032
Last modified:June 1, 1998 - v1
Checksum:i40D3CCAC9ACB7D98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66733.1.
PIRiC70143.
RefSeqiNP_212482.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAC66733; AAC66733; BB_0348.
GeneIDi1195185.
KEGGibbu:BB_0348.
PATRICi20557308. VBIBorBur75917_0744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66733.1 .
PIRi C70143.
RefSeqi NP_212482.1. NC_001318.1.

3D structure databases

ProteinModelPortali O51323.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224326.BB0348.

Proteomic databases

PRIDEi O51323.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC66733 ; AAC66733 ; BB_0348 .
GeneIDi 1195185.
KEGGi bbu:BB_0348.
PATRICi 20557308. VBIBorBur75917_0744.

Phylogenomic databases

eggNOGi COG0469.
KOi K00873.
OMAi GTHEEHK.
OrthoDBi EOG6GBMB0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .
BioCyci BBUR224326:G9SO-346-MONOMER.

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry nameiKPYK_BORBU
AccessioniPrimary (citable) accession number: O51323
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3