Reviewed, UniProtKB/Swiss-Prot O51291 (PPNK_BORBU)

Names and origin

Protein names

Recommended name:
    Probable inorganic polyphosphate/ATP-NAD kinase
      Short name=Poly(P)/ATP NAD kinase
    EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	BB_0311

Organism

Borrelia burgdorferi (Lyme disease spirochete) [Complete proteome] [HAMAP]

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity.
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_0000120602

Sequences

	Sequence		Length	Mass (Da)
	O51291-1 [UniParc]. Last modified May 4, 2001. Version 2. Checksum: 1592FC198FAFE96C	FASTA	279	30,967
	10 20 30 40 50 60 MKNKVLLCIN TLKSGASILG NDVKVYLETK YFVEVVLIDV GRPLFSFPKE NFLFLITLGG 70 80 90 100 110 120 DGTVLLAVNL LLENENIDIP IISINMGNVG FLADIKIEDF KKVIDRFFNN SLVINKKFLL 130 140 150 160 170 180 HVTVSQHGKD LISKYALNDI IIRSSVLNKM IYVDLMVNSE SFLSYKSDGI IVSTPTGSTG 190 200 210 220 230 240 YSFSAGGPIL EADLEGFXLT PISPHSVYNR SFVFSKLSKL SISFSKEYFI AAASIFLDGI 250 260 270 NFGSFGVDVV FEFKISSQSL NFVSFCTDTF VKRLKNKLL

References

[1]

"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000783 Genomic DNA. Translation: AAC66699.1. Different initiation.
RefSeq	NP_212445.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1195148.
GenomeReviews	Gene locus BB_0311 in contig AE000783_GR.
KEGG	bbu:BB0311.
NMPDR	fig|224326.1.peg.695.
TIGR	BB_0311.
Phylogenomic databases
HOGENOM	O51291.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0311-MON.
BRENDA	2.7.1.23. 142596.
Family and domain databases
HAMAP	MF_00361. [Tree]
InterPro	IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. ATP_NADK. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPNK_BORBU

Accession

Primary (citable) accession number: O51291

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 4, 2001
Last modified:	June 16, 2009
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)